High speed in-vivo imaging of retinal hemodynamics in a rodent model of hypertension

Rezaeian, M; Georgevsky, D; Golzan, SM; Graham, SL

High speed in-vivo imaging of retinal hemodynamics in a rodent model of hypertension

Rezaeian, M

Georgevsky, D Golzan, SM

Graham, SL

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Publication Type:: Conference Proceeding
Citation:: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, 2016, 2016-October pp. 3243 - 3246
Issue Date:: 2016-10-13

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Field	Value	Language
dc.contributor.author	Rezaeian, M https://orcid.org/0000-0003-2333-1593	en_US
dc.contributor.author	Georgevsky, D	en_US
dc.contributor.author	Golzan, SM https://orcid.org/0000-0002-4479-3917	en_US
dc.contributor.author	Graham, SL	en_US
dc.date.issued	2016-10-13	en_US
dc.identifier.citation	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, 2016, 2016-October pp. 3243 - 3246	en_US
dc.identifier.isbn	9781457702204	en_US
dc.identifier.issn	1557-170X	en_US
dc.identifier.uri	http://hdl.handle.net/10453/120293
dc.description.abstract	© 2016 IEEE. The eye is the only organ through which microcirculation can be visualized non-invasively. This unique feature makes the eye and specifically retinal vasculature an excellent target area to monitor and study micro-vascular damage in systemic diseases. Dynamic (real-time) changes of retinal vessels have been shown to be more specific to the disease in comparison with static measurements. In this study we utilize high speed imaging (i.e. 125 fps) to study and derive dynamic changes of retinal vessels in a rat model of hypertension. A Eulerian video magnification algorithm was used to extract retinal arterial and venous pulse amplitude from five Spontaneously Hypertensive Rats (SHR) and five Wister Kyoto (WKY) rats were used as the control group. Results showed that retinal arterial diameter and pulse amplitude are significantly lower in the SHRs compared with WKYs. Dynamic biomarkers of retinal micro-vasculature may be used as a diagnostic tool for systemic diseases.	en_US
dc.relation.ispartof	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS	en_US
dc.relation.isbasedon	10.1109/EMBC.2016.7591420	en_US
dc.subject.mesh	Retinal Vessels	en_US
dc.subject.mesh	Retina	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Rats, Inbred SHR	en_US
dc.subject.mesh	Rats, Inbred WKY	en_US
dc.subject.mesh	Hypertension	en_US
dc.subject.mesh	Disease Models, Animal	en_US
dc.subject.mesh	Contrast Media	en_US
dc.subject.mesh	Imaging, Three-Dimensional	en_US
dc.subject.mesh	Heart Rate	en_US
dc.subject.mesh	Image Processing, Computer-Assisted	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Hemodynamics	en_US
dc.title	High speed in-vivo imaging of retinal hemodynamics in a rodent model of hypertension	en_US
dc.type	Conference Proceeding
utslib.citation.volume	2016-October	en_US
utslib.for	1113 Opthalmology and Optometry	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	2016-October	en_US

Abstract:

© 2016 IEEE. The eye is the only organ through which microcirculation can be visualized non-invasively. This unique feature makes the eye and specifically retinal vasculature an excellent target area to monitor and study micro-vascular damage in systemic diseases. Dynamic (real-time) changes of retinal vessels have been shown to be more specific to the disease in comparison with static measurements. In this study we utilize high speed imaging (i.e. 125 fps) to study and derive dynamic changes of retinal vessels in a rat model of hypertension. A Eulerian video magnification algorithm was used to extract retinal arterial and venous pulse amplitude from five Spontaneously Hypertensive Rats (SHR) and five Wister Kyoto (WKY) rats were used as the control group. Results showed that retinal arterial diameter and pulse amplitude are significantly lower in the SHRs compared with WKYs. Dynamic biomarkers of retinal micro-vasculature may be used as a diagnostic tool for systemic diseases.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/120293