Needle-free transdermal delivery using PLGA nanoparticles: Effect of particle size, injection pressure and syringe orifice diameter

Park, CH; Tijing, LD; Kim, CS; Lee, KM

Needle-free transdermal delivery using PLGA nanoparticles: Effect of particle size, injection pressure and syringe orifice diameter

Park, CH Tijing, LD

Kim, CS Lee, KM

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Publication Type:: Journal Article
Citation:: Colloids and Surfaces B: Biointerfaces, 2014, 123 pp. 710 - 715
Issue Date:: 2014-11-01

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Field	Value	Language
dc.contributor.author	Park, CH	en_US
dc.contributor.author	Tijing, LD https://orcid.org/0000-0001-9398-6355	en_US
dc.contributor.author	Kim, CS	en_US
dc.contributor.author	Lee, KM	en_US
dc.date.available	2014-10-05	en_US
dc.date.issued	2014-11-01	en_US
dc.identifier.citation	Colloids and Surfaces B: Biointerfaces, 2014, 123 pp. 710 - 715	en_US
dc.identifier.issn	0927-7765	en_US
dc.identifier.uri	http://hdl.handle.net/10453/122523
dc.description.abstract	© 2014 Elsevier B.V. The aim of this study is to investigate the effects of particle size and other injection factors on the skin penetration of nanoparticles delivered with a needle-free injector. Experimental and simulation tests were carried out at various parameters. In addition to testing different sizes of nanoparticles, we also observed the effects of several injection pressures and syringe orifice diameters (SOD) on the dispersion pattern of the nanoparticles after injection. Our results showed that as the nanoparticle size increased from 45. nm to 452. nm, the resulting puncture opening, channel diameter, and depth of the nanoparticle dispersion decreased, but the width of the dispersion increased. Conversely, as the SOD increased, the puncture opening, channel diameter, and depth of the dispersion increased, but width of the dispersion decreased. Increasing the injection pressure also decreased the size, depth, and width of the puncture opening. These results identify how these three parameters affect nanoparticle delivery from a needle-free injector; therefore, our findings will be beneficial for optimization and further study of needle-free injectors as a mechanism for transdermal delivery of nanoparticles.	en_US
dc.relation.ispartof	Colloids and Surfaces B: Biointerfaces	en_US
dc.relation.isbasedon	10.1016/j.colsurfb.2014.10.009	en_US
dc.subject.classification	Chemical Physics	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Mice	en_US
dc.subject.mesh	Lactic Acid	en_US
dc.subject.mesh	Polyglycolic Acid	en_US
dc.subject.mesh	Drug Delivery Systems	en_US
dc.subject.mesh	Administration, Cutaneous	en_US
dc.subject.mesh	Skin Absorption	en_US
dc.subject.mesh	Particle Size	en_US
dc.subject.mesh	Nanoparticles	en_US
dc.subject.mesh	Polylactic Acid-Polyglycolic Acid Copolymer	en_US
dc.title	Needle-free transdermal delivery using PLGA nanoparticles: Effect of particle size, injection pressure and syringe orifice diameter	en_US
dc.type	Journal Article
utslib.citation.volume	123	en_US
utslib.for	0904 Chemical Engineering	en_US
utslib.for	0306 Physical Chemistry (incl. Structural)	en_US
utslib.for	0903 Biomedical Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Civil and Environmental Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CTWW - Centre for Technology in Water and Wastewater Treatment
utslib.copyright.status	open_access
pubs.publication-status	Published	en_US
pubs.volume	123	en_US

Abstract:

© 2014 Elsevier B.V. The aim of this study is to investigate the effects of particle size and other injection factors on the skin penetration of nanoparticles delivered with a needle-free injector. Experimental and simulation tests were carried out at various parameters. In addition to testing different sizes of nanoparticles, we also observed the effects of several injection pressures and syringe orifice diameters (SOD) on the dispersion pattern of the nanoparticles after injection. Our results showed that as the nanoparticle size increased from 45. nm to 452. nm, the resulting puncture opening, channel diameter, and depth of the nanoparticle dispersion decreased, but the width of the dispersion increased. Conversely, as the SOD increased, the puncture opening, channel diameter, and depth of the dispersion increased, but width of the dispersion decreased. Increasing the injection pressure also decreased the size, depth, and width of the puncture opening. These results identify how these three parameters affect nanoparticle delivery from a needle-free injector; therefore, our findings will be beneficial for optimization and further study of needle-free injectors as a mechanism for transdermal delivery of nanoparticles.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/122523