Delirium post-stroke: Short- to long-term effect on anxiety and depression compared to effect on cognition

Chan, EKW; Shen, Q; Cordato, D; Kneebone, I; Xu, YH; Chan, DKY

Delirium post-stroke: Short- to long-term effect on anxiety and depression compared to effect on cognition

Chan, EKW Shen, Q Cordato, D Kneebone, I

Xu, YH Chan, DKY

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Publication Type:: Journal Article
Citation:: Topics in Stroke Rehabilitation, 2017, 24 (8), pp. 597 - 600
Issue Date:: 2017-09-22

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Field	Value	Language
dc.contributor.author	Chan, EKW	en_US
dc.contributor.author	Shen, Q	en_US
dc.contributor.author	Cordato, D	en_US
dc.contributor.author	Kneebone, I https://orcid.org/0000-0003-3324-7264	en_US
dc.contributor.author	Xu, YH	en_US
dc.contributor.author	Chan, DKY	en_US
dc.date.issued	2017-09-22	en_US
dc.identifier.citation	Topics in Stroke Rehabilitation, 2017, 24 (8), pp. 597 - 600	en_US
dc.identifier.issn	1074-9357	en_US
dc.identifier.uri	http://hdl.handle.net/10453/123413
dc.description.abstract	© 2017 Informa UK Limited, trading as Taylor & Francis Group. Background: Delirium is common after stroke and has significant negative impact on mortality, morbidity, cognitive function, and institutionalization. Despite these known effects, any impact of delirium on the emotional well-being of stroke survivors is unclear. Methods: A post hoc analysis was performed on our prospective cohort study of 156 stroke patients. Hospital Anxiety and Depression (HAD) scale scores were compared between patients with delirium and patients without delirium at 1-month, 6-month, and 12-month post-stroke. Results: Contrary to the negative impact of delirium on cognition and functional status, we did not discern any influence on HAD scale scores in the short to long term. The median scores of the HAD anxiety scale were 4 (interquartile range IQR 3) at 1 month, 5.5 (IQR 8.75) at 6 months, and 6 (IQR 5) at 12 months in the delirium group compared to 5 (IQR 7) at 1 month (p = 0.6), 4 (IQR 7) at 6 months (p = 0.4), and 6 (IQR 5.75) at 12 months (p = 0.9) in the non-delirium group, respectively. Similarly, the median scores of the HAD depression scale were 5 (IQR 4) at 1 month, 4 (IQR 6.5) at 6 months, and 3 (IQR 6) at 12 months in the delirium group compared to 6 (IQR 5.75) at 1 month (p = 0.9), 5 (IQR 7) at 6 months (p = 0.9), and 6 (IQR 5) at 12 months (p = 0.5) in the non-delirium group. Conclusion: Delirium may not have a significant effect on the development of anxiety or depression after stroke which differs in its effect on cognitive function and functional status.	en_US
dc.relation.ispartof	Topics in Stroke Rehabilitation	en_US
dc.relation.isbasedon	10.1080/10749357.2017.1373490	en_US
dc.subject.classification	Rehabilitation	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Delirium	en_US
dc.subject.mesh	Risk Factors	en_US
dc.subject.mesh	Follow-Up Studies	en_US
dc.subject.mesh	Prospective Studies	en_US
dc.subject.mesh	Depression	en_US
dc.subject.mesh	Anxiety	en_US
dc.subject.mesh	Cognition	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Survivors	en_US
dc.subject.mesh	Stroke	en_US
dc.title	Delirium post-stroke: Short- to long-term effect on anxiety and depression compared to effect on cognition	en_US
dc.type	Journal Article
utslib.citation.volume	8	en_US
utslib.citation.volume	24	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	1109 Neurosciences	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
utslib.copyright.status	closed_access
pubs.issue	8	en_US
pubs.publication-status	Published	en_US
pubs.volume	24	en_US

Abstract:

© 2017 Informa UK Limited, trading as Taylor & Francis Group. Background: Delirium is common after stroke and has significant negative impact on mortality, morbidity, cognitive function, and institutionalization. Despite these known effects, any impact of delirium on the emotional well-being of stroke survivors is unclear. Methods: A post hoc analysis was performed on our prospective cohort study of 156 stroke patients. Hospital Anxiety and Depression (HAD) scale scores were compared between patients with delirium and patients without delirium at 1-month, 6-month, and 12-month post-stroke. Results: Contrary to the negative impact of delirium on cognition and functional status, we did not discern any influence on HAD scale scores in the short to long term. The median scores of the HAD anxiety scale were 4 (interquartile range IQR 3) at 1 month, 5.5 (IQR 8.75) at 6 months, and 6 (IQR 5) at 12 months in the delirium group compared to 5 (IQR 7) at 1 month (p = 0.6), 4 (IQR 7) at 6 months (p = 0.4), and 6 (IQR 5.75) at 12 months (p = 0.9) in the non-delirium group, respectively. Similarly, the median scores of the HAD depression scale were 5 (IQR 4) at 1 month, 4 (IQR 6.5) at 6 months, and 3 (IQR 6) at 12 months in the delirium group compared to 6 (IQR 5.75) at 1 month (p = 0.9), 5 (IQR 7) at 6 months (p = 0.9), and 6 (IQR 5) at 12 months (p = 0.5) in the non-delirium group. Conclusion: Delirium may not have a significant effect on the development of anxiety or depression after stroke which differs in its effect on cognitive function and functional status.

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http://hdl.handle.net/10453/123413