Continuous transformation of chiral pharmaceuticals in enzymatic membrane bioreactors for advanced wastewater treatment

Nguyen, LN; Hai, FI; McDonald, JA; Khan, SJ; Price, WE; Nghiem, LD

Continuous transformation of chiral pharmaceuticals in enzymatic membrane bioreactors for advanced wastewater treatment

Nguyen, LN

Hai, FI McDonald, JA Khan, SJ Price, WE Nghiem, LD

Permalink

Publication Type:: Journal Article
Citation:: Water Science and Technology, 2017, 76 (7), pp. 1816 - 1826
Issue Date:: 2017-10-01

Closed Access

	Filename	Description	Size
	Continuous transformation of chiral pharmaceuticals in enzymatic.pdf	Published Version	347.84 kB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Nguyen, LN https://orcid.org/0000-0001-5360-886X	en_US
dc.contributor.author	Hai, FI	en_US
dc.contributor.author	McDonald, JA	en_US
dc.contributor.author	Khan, SJ	en_US
dc.contributor.author	Price, WE	en_US
dc.contributor.author	Nghiem, LD https://orcid.org/0000-0002-9039-5792	en_US
dc.date.issued	2017-10-01	en_US
dc.identifier.citation	Water Science and Technology, 2017, 76 (7), pp. 1816 - 1826	en_US
dc.identifier.issn	0273-1223	en_US
dc.identifier.uri	http://hdl.handle.net/10453/124058
dc.description.abstract	© IWA Publishing 2017. This study demonstrates continuous enantiomeric inversion and further biotransformation of chiral profens including ibuprofen, naproxen and ketoprofen by an enzymatic membrane bioreactor (EMBR) dosed with laccase. The EMBR showed non-enantioselective transformations, with high and consistent transformation of both (R)- and (S)-ibuprofen (93 ± 6%, n = 10), but lower removals of both enantiomers of naproxen (46 ± 16%, n = 10) and ketoprofen (48 ± 17%, n = 10). Enantiomeric analysis revealed a bidirectional but uneven inversion of the profens, for example 14% inversion of (R)- to (S)- compared to 4% from (S)- to (R)-naproxen. With redox-mediator addition, the enzymatic chiral inversion of both (R)- and (S)-profens remained unchanged, although the overall conversion became enantioselective; except for (S)-naproxen, the addition of redox mediator promoted the degradation of (R)-profens only.	en_US
dc.relation.ispartof	Water Science and Technology	en_US
dc.relation.isbasedon	10.2166/wst.2017.331	en_US
dc.subject.classification	Environmental Engineering	en_US
dc.subject.mesh	Ibuprofen	en_US
dc.subject.mesh	Ketoprofen	en_US
dc.subject.mesh	Naproxen	en_US
dc.subject.mesh	Anti-Inflammatory Agents, Non-Steroidal	en_US
dc.subject.mesh	Membranes, Artificial	en_US
dc.subject.mesh	Water Pollutants, Chemical	en_US
dc.subject.mesh	Bioreactors	en_US
dc.subject.mesh	Biotransformation	en_US
dc.subject.mesh	Waste Water	en_US
dc.title	Continuous transformation of chiral pharmaceuticals in enzymatic membrane bioreactors for advanced wastewater treatment	en_US
dc.type	Journal Article
utslib.citation.volume	7	en_US
utslib.citation.volume	76	en_US
utslib.for	1003 Industrial Biotechnology	en_US
utslib.for	0502 Environmental Science and Management	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Civil and Environmental Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CTWW - Centre for Technology in Water and Wastewater Treatment
utslib.copyright.status	closed_access
pubs.issue	7	en_US
pubs.publication-status	Published	en_US
pubs.volume	76	en_US

Abstract:

© IWA Publishing 2017. This study demonstrates continuous enantiomeric inversion and further biotransformation of chiral profens including ibuprofen, naproxen and ketoprofen by an enzymatic membrane bioreactor (EMBR) dosed with laccase. The EMBR showed non-enantioselective transformations, with high and consistent transformation of both (R)- and (S)-ibuprofen (93 ± 6%, n = 10), but lower removals of both enantiomers of naproxen (46 ± 16%, n = 10) and ketoprofen (48 ± 17%, n = 10). Enantiomeric analysis revealed a bidirectional but uneven inversion of the profens, for example 14% inversion of (R)- to (S)- compared to 4% from (S)- to (R)-naproxen. With redox-mediator addition, the enzymatic chiral inversion of both (R)- and (S)-profens remained unchanged, although the overall conversion became enantioselective; except for (S)-naproxen, the addition of redox mediator promoted the degradation of (R)-profens only.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/124058