Formation of struvite urinary stones and approaches towards the inhibition—A review

Das, P; Gupta, G; Velu, V; Awasthi, R; Dua, K; Malipeddi, H

Formation of struvite urinary stones and approaches towards the inhibition—A review

Das, P Gupta, G Velu, V Awasthi, R Dua, K

Malipeddi, H

Permalink

Publication Type:: Journal Article
Citation:: Biomedicine and Pharmacotherapy, 2017, 96 pp. 361 - 370
Issue Date:: 2017-12-01

Closed Access

	Filename	Description	Size
	1-s2.0-S0753332217331554-main.pdf	Published Version	919.8 kB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Das, P	en_US
dc.contributor.author	Gupta, G	en_US
dc.contributor.author	Velu, V	en_US
dc.contributor.author	Awasthi, R	en_US
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159	en_US
dc.contributor.author	Malipeddi, H	en_US
dc.date.available	2017-10-02	en_US
dc.date.issued	2017-12-01	en_US
dc.identifier.citation	Biomedicine and Pharmacotherapy, 2017, 96 pp. 361 - 370	en_US
dc.identifier.issn	0753-3322	en_US
dc.identifier.uri	http://hdl.handle.net/10453/124820
dc.description.abstract	© 2017 Elsevier Masson SAS Background Struvite is one of the most common urinary/kidney stones, composed of magnesium ammonium phosphate (MgNHPO4·H2O). They are also termed as infection stones as these are associated with urinary tract infections. Numerous studies have been carried out to examine the growth and inhibition of struvite stones. Objective This review summarizes various reports on the factors responsible for inducing struvite stones in the kidney and gives a detailed account of studies on inhibition of growth of struvite crystals. Results The presence of urea-splitting bacteria such as Proteus mirabilis and alkaline pH plays a crucial role in struvite formation. In vitro inhibition of struvite stones by various chemical agents were examined mainly in artificial urine whereas inhibition by herbal extracts was studied in vitro by gel diffusion technique. Herbal extracts of curcumin, Boerhaavia diffusa Linn, Rotula aquatica and many other plants, as well as some chemicals like pyrophosphate, acetohydroxamic acid, disodium EDTA and trisodium citrate, were reported to successfully inhibit struvite formation. Conclusion The present review recapitulates various factors affecting the growth of struvite urinary stones and the inhibitory role of certain chemicals and herbal extracts. Most of the tested plants are edible hence can be easily consumed without any adverse effects whereas the side effects of chemicals are unknown due to lack of toxicity studies. Thus, the use of herbal extracts might serve as an alternate and safe therapy for prevention of struvite stones.	en_US
dc.relation.ispartof	Biomedicine and Pharmacotherapy	en_US
dc.relation.isbasedon	10.1016/j.biopha.2017.10.015	en_US
dc.subject.classification	Oncology & Carcinogenesis	en_US
dc.subject.mesh	Kidney	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Urinary Tract Infections	en_US
dc.subject.mesh	Urinary Calculi	en_US
dc.subject.mesh	Plant Preparations	en_US
dc.subject.mesh	Crystallization	en_US
dc.subject.mesh	Urolithiasis	en_US
dc.subject.mesh	Struvite	en_US
dc.title	Formation of struvite urinary stones and approaches towards the inhibition—A review	en_US
dc.type	Journal Article
utslib.citation.volume	96	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	96	en_US

Abstract:

© 2017 Elsevier Masson SAS Background Struvite is one of the most common urinary/kidney stones, composed of magnesium ammonium phosphate (MgNHPO4·H2O). They are also termed as infection stones as these are associated with urinary tract infections. Numerous studies have been carried out to examine the growth and inhibition of struvite stones. Objective This review summarizes various reports on the factors responsible for inducing struvite stones in the kidney and gives a detailed account of studies on inhibition of growth of struvite crystals. Results The presence of urea-splitting bacteria such as Proteus mirabilis and alkaline pH plays a crucial role in struvite formation. In vitro inhibition of struvite stones by various chemical agents were examined mainly in artificial urine whereas inhibition by herbal extracts was studied in vitro by gel diffusion technique. Herbal extracts of curcumin, Boerhaavia diffusa Linn, Rotula aquatica and many other plants, as well as some chemicals like pyrophosphate, acetohydroxamic acid, disodium EDTA and trisodium citrate, were reported to successfully inhibit struvite formation. Conclusion The present review recapitulates various factors affecting the growth of struvite urinary stones and the inhibitory role of certain chemicals and herbal extracts. Most of the tested plants are edible hence can be easily consumed without any adverse effects whereas the side effects of chemicals are unknown due to lack of toxicity studies. Thus, the use of herbal extracts might serve as an alternate and safe therapy for prevention of struvite stones.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/124820