The non-coding RNA landscape of human hematopoiesis and leukemia

Schwarzer, A; Emmrich, S; Schmidt, F; Beck, D; Ng, M; Reimer, C; Adams, FF; Grasedieck, S; Witte, D; Käbler, S; Wong, JWH; Shah, A; Huang, Y; Jammal, R; Maroz, A; Jongen-Lavrencic, M; Schambach, A; Kuchenbauer, F; Pimanda, JE; Reinhardt, D; Heckl, D; Klusmann, JH

The non-coding RNA landscape of human hematopoiesis and leukemia

Schwarzer, A Emmrich, S Schmidt, F Beck, D Ng, M Reimer, C Adams, FF Grasedieck, S Witte, D Käbler, S Wong, JWH Shah, A Huang, Y

Jammal, R Maroz, A Jongen-Lavrencic, M Schambach, A Kuchenbauer, F Pimanda, JE

Reinhardt, D Heckl, D Klusmann, JH

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Publication Type:: Journal Article
Citation:: Nature Communications, 2017, 8 (1)
Issue Date:: 2017-12-01

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Field	Value	Language
dc.contributor.author	Schwarzer, A	en_US
dc.contributor.author	Emmrich, S	en_US
dc.contributor.author	Schmidt, F	en_US
dc.contributor.author	Beck, D	en_US
dc.contributor.author	Ng, M	en_US
dc.contributor.author	Reimer, C	en_US
dc.contributor.author	Adams, FF	en_US
dc.contributor.author	Grasedieck, S	en_US
dc.contributor.author	Witte, D	en_US
dc.contributor.author	Käbler, S	en_US
dc.contributor.author	Wong, JWH	en_US
dc.contributor.author	Shah, A	en_US
dc.contributor.author	Huang, Y https://orcid.org/0000-0002-7003-3110	en_US
dc.contributor.author	Jammal, R	en_US
dc.contributor.author	Maroz, A	en_US
dc.contributor.author	Jongen-Lavrencic, M	en_US
dc.contributor.author	Schambach, A	en_US
dc.contributor.author	Kuchenbauer, F	en_US
dc.contributor.author	Pimanda, JE https://orcid.org/0000-0002-0509-8962	en_US
dc.contributor.author	Reinhardt, D	en_US
dc.contributor.author	Heckl, D	en_US
dc.contributor.author	Klusmann, JH	en_US
dc.date.available	2017-06-13	en_US
dc.date.issued	2017-12-01	en_US
dc.identifier.citation	Nature Communications, 2017, 8 (1)	en_US
dc.identifier.uri	http://hdl.handle.net/10453/125092
dc.description.abstract	© The Author(s) 2017. Non-coding RNAs have emerged as crucial regulators of gene expression and cell fate decisions. However, their expression patterns and regulatory functions during normal and malignant human hematopoiesis are incompletely understood. Here we present a comprehensive resource defining the non-coding RNA landscape of the human hematopoietic system. Based on highly specific non-coding RNA expression portraits per blood cell population, we identify unique fingerprint non-coding RNAs-such as LINC00173 in granulocytes-and assign these to critical regulatory circuits involved in blood homeostasis. Following the incorporation of acute myeloid leukemia samples into the landscape, we further uncover prognostically relevant non-coding RNA stem cell signatures shared between acute myeloid leukemia blasts and healthy hematopoietic stem cells. Our findings highlight the importance of the non-coding transcriptome in the formation and maintenance of the human blood hierarchy.	en_US
dc.relation	http://purl.org/au-research/grants/nhmrc/APP1073768
dc.relation.ispartof	Nature Communications	en_US
dc.relation.isbasedon	10.1038/s41467-017-00212-4	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Leukemia	en_US
dc.subject.mesh	RNA, Untranslated	en_US
dc.subject.mesh	Gene Expression Profiling	en_US
dc.subject.mesh	Hematopoiesis	en_US
dc.subject.mesh	Cell Lineage	en_US
dc.subject.mesh	HEK293 Cells	en_US
dc.subject.mesh	RNA, Long Noncoding	en_US
dc.title	The non-coding RNA landscape of human hematopoiesis and leukemia	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	8	en_US
utslib.for	0304 Medicinal and Biomolecular Chemistry	en_US
utslib.for	MD Multidisciplinary	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Software
pubs.organisational-group	/University of Technology Sydney/Strength - AAI - Advanced Analytics Institute Research Centre
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	8	en_US

Abstract:

© The Author(s) 2017. Non-coding RNAs have emerged as crucial regulators of gene expression and cell fate decisions. However, their expression patterns and regulatory functions during normal and malignant human hematopoiesis are incompletely understood. Here we present a comprehensive resource defining the non-coding RNA landscape of the human hematopoietic system. Based on highly specific non-coding RNA expression portraits per blood cell population, we identify unique fingerprint non-coding RNAs-such as LINC00173 in granulocytes-and assign these to critical regulatory circuits involved in blood homeostasis. Following the incorporation of acute myeloid leukemia samples into the landscape, we further uncover prognostically relevant non-coding RNA stem cell signatures shared between acute myeloid leukemia blasts and healthy hematopoietic stem cells. Our findings highlight the importance of the non-coding transcriptome in the formation and maintenance of the human blood hierarchy.

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http://hdl.handle.net/10453/125092