Role of microRNAs (miRNAs) in the pathophysiology of Diabetes mellitus

Tiwari, J; Gupta, G; De Jesus Andreoli Pinto, T; Sharma, R; Pabreja, K; Matta, Y; Arora, N; Mishra, A; Dua, K

Role of microRNAs (miRNAs) in the pathophysiology of Diabetes mellitus

Tiwari, J Gupta, G De Jesus Andreoli Pinto, T Sharma, R Pabreja, K Matta, Y Arora, N Mishra, A Dua, K

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Publication Type:: Journal Article
Citation:: Panminerva Medica, 2018, 60 (1), pp. 25 - 28
Issue Date:: 2018-03-01

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Field	Value	Language
dc.contributor.author	Tiwari, J	en_US
dc.contributor.author	Gupta, G	en_US
dc.contributor.author	De Jesus Andreoli Pinto, T	en_US
dc.contributor.author	Sharma, R	en_US
dc.contributor.author	Pabreja, K	en_US
dc.contributor.author	Matta, Y	en_US
dc.contributor.author	Arora, N	en_US
dc.contributor.author	Mishra, A	en_US
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159	en_US
dc.date.issued	2018-03-01	en_US
dc.identifier.citation	Panminerva Medica, 2018, 60 (1), pp. 25 - 28	en_US
dc.identifier.issn	0031-0808	en_US
dc.identifier.uri	http://hdl.handle.net/10453/125327
dc.description.abstract	© 2017 EDIZIONI MINERVA MEDICA. Diabetes mellitus is becoming the critical problem among the entire world and it is difficult to understand the molecular mechanism representing the concept of diabetic pathology. Recently the knowledge of the involvement of genetics in type 2 diabetes mellitus (T2DM) susceptibility has sketched a great concentration towards the transcriptional activity of β cells within the pancreas. This disease becomes the leading cause of death, so it is necessary to study the molecular pathogenesis, phenotypes, and characteristics to design the therapeutic parameters. Here in this review role of miRNA is being illustrated as it plays a crucial role in the pathogenesis, progression, and fate of beta cells of pancreas regulating the insulin secretion. Here in this review, we try to include the effects and pathophysiology of various miRNA in diabetes mellitus and on the various sites of the human body.	en_US
dc.relation.ispartof	Panminerva Medica	en_US
dc.relation.isbasedon	10.23736/S0031-0808.17.03382-1	en_US
dc.subject.classification	Cardiovascular System & Hematology	en_US
dc.subject.mesh	Pancreas	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Mice	en_US
dc.subject.mesh	Rats	en_US
dc.subject.mesh	Diabetes Mellitus, Type 2	en_US
dc.subject.mesh	Disease Progression	en_US
dc.subject.mesh	Genetic Predisposition to Disease	en_US
dc.subject.mesh	Insulin	en_US
dc.subject.mesh	MicroRNAs	en_US
dc.subject.mesh	Cell Differentiation	en_US
dc.subject.mesh	Cell Proliferation	en_US
dc.subject.mesh	Transcription, Genetic	en_US
dc.subject.mesh	Phenotype	en_US
dc.subject.mesh	Insulin-Secreting Cells	en_US
dc.title	Role of microRNAs (miRNAs) in the pathophysiology of Diabetes mellitus	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	60	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
utslib.copyright.status	open_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	60	en_US

Abstract:

© 2017 EDIZIONI MINERVA MEDICA. Diabetes mellitus is becoming the critical problem among the entire world and it is difficult to understand the molecular mechanism representing the concept of diabetic pathology. Recently the knowledge of the involvement of genetics in type 2 diabetes mellitus (T2DM) susceptibility has sketched a great concentration towards the transcriptional activity of β cells within the pancreas. This disease becomes the leading cause of death, so it is necessary to study the molecular pathogenesis, phenotypes, and characteristics to design the therapeutic parameters. Here in this review role of miRNA is being illustrated as it plays a crucial role in the pathogenesis, progression, and fate of beta cells of pancreas regulating the insulin secretion. Here in this review, we try to include the effects and pathophysiology of various miRNA in diabetes mellitus and on the various sites of the human body.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/125327