Corticospinal excitability changes following blood flow restriction training of the tibialis anterior: a preliminary study

Næss-Schmidt, ET; Morthorst, M; Pedersen, AR; Nielsen, JF; Stubbs, PW

Corticospinal excitability changes following blood flow restriction training of the tibialis anterior: a preliminary study

Næss-Schmidt, ET Morthorst, M Pedersen, AR Nielsen, JF Stubbs, PW

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Publication Type:: Journal Article
Citation:: Heliyon, 2017, 3 (1)
Issue Date:: 2017-01-01

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Field	Value	Language
dc.contributor.author	Næss-Schmidt, ET	en_US
dc.contributor.author	Morthorst, M	en_US
dc.contributor.author	Pedersen, AR	en_US
dc.contributor.author	Nielsen, JF	en_US
dc.contributor.author	Stubbs, PW https://orcid.org/0000-0003-4555-8019	en_US
dc.date.available	2016-12-16	en_US
dc.date.issued	2017-01-01	en_US
dc.identifier.citation	Heliyon, 2017, 3 (1)	en_US
dc.identifier.issn	2405-8440	en_US
dc.identifier.uri	http://hdl.handle.net/10453/125535
dc.description.abstract	© 2017 The Authors Aim To examine the neural excitability of projections to the tibialis anterior (TA) following blood flow restriction training (BFRT). This is the first study to examine the TA following BFRT. Methods Ten subjects performed each experiment. Experiment one consisted of BFRT at 130 mmHg (BFRT-low). Experiment two consisted of BFRT at 200 mmHg (BFRT-high), training (TR-only) and blood flow restriction at 200 mmHg (BFR-only) performed on separate days. Blood flow restriction was applied to the thigh and training consisted of rapid dorsiflexion contractions against gravity every 10 s for 15-min. The motor evoked potential (MEP) peak-to-peak amplitudes were recorded pre-intervention and 1-, 10-, 20- and 30-min post-intervention and expressed relative to the maximal peak-to-peak M-wave at each time-point. Results Experiment one revealed no difference in MEP amplitudes for BFRT-low over time (P = 0.09). Experiment two revealed a significant effect of time (P < 0.001), with 1-min post-intervention MEP amplitudes significantly facilitated compared to pre-intervention, but no effect of intervention (P = 0.79) or interventiontime interaction (P = 0.25). Post-hoc power calculations were performed for the interventiontime interaction. Discussion and conclusions Corticospinal excitability of projections to the TA did not change following BFRT-low and corticospinal excitability changes between BFRT-high, BFR-only and TR-only interventions were not different over time. In experiment two, there was a significant main effect of time 1-min post-intervention which was mainly due to the BFRT-high intervention. Post-hoc power calculations revealed that 15 subjects were required for a significant interaction effect 80% of the time however, as the changes in corticospinal excitability were not prolonged, a new dataset of ≥ 15 subjects was not acquired.	en_US
dc.relation.ispartof	Heliyon	en_US
dc.relation.isbasedon	10.1016/j.heliyon.2016.e00217	en_US
dc.title	Corticospinal excitability changes following blood flow restriction training of the tibialis anterior: a preliminary study	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	3	en_US
utslib.for	1109 Neurosciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
utslib.copyright.status	open_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	3	en_US

Abstract:

© 2017 The Authors Aim To examine the neural excitability of projections to the tibialis anterior (TA) following blood flow restriction training (BFRT). This is the first study to examine the TA following BFRT. Methods Ten subjects performed each experiment. Experiment one consisted of BFRT at 130 mmHg (BFRT-low). Experiment two consisted of BFRT at 200 mmHg (BFRT-high), training (TR-only) and blood flow restriction at 200 mmHg (BFR-only) performed on separate days. Blood flow restriction was applied to the thigh and training consisted of rapid dorsiflexion contractions against gravity every 10 s for 15-min. The motor evoked potential (MEP) peak-to-peak amplitudes were recorded pre-intervention and 1-, 10-, 20- and 30-min post-intervention and expressed relative to the maximal peak-to-peak M-wave at each time-point. Results Experiment one revealed no difference in MEP amplitudes for BFRT-low over time (P = 0.09). Experiment two revealed a significant effect of time (P < 0.001), with 1-min post-intervention MEP amplitudes significantly facilitated compared to pre-intervention, but no effect of intervention (P = 0.79) or intervention*time interaction (P = 0.25). Post-hoc power calculations were performed for the intervention*time interaction. Discussion and conclusions Corticospinal excitability of projections to the TA did not change following BFRT-low and corticospinal excitability changes between BFRT-high, BFR-only and TR-only interventions were not different over time. In experiment two, there was a significant main effect of time 1-min post-intervention which was mainly due to the BFRT-high intervention. Post-hoc power calculations revealed that 15 subjects were required for a significant interaction effect 80% of the time however, as the changes in corticospinal excitability were not prolonged, a new dataset of ≥ 15 subjects was not acquired.

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http://hdl.handle.net/10453/125535