Formulation and evaluation of controlled-release matrix systems of ciprofloxacin.

Malipeddi, VR; Awasthi, R; Dua, K

Formulation and evaluation of controlled-release matrix systems of ciprofloxacin.

Malipeddi, VR Awasthi, R Dua, K

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Publication Type:: Journal Article
Citation:: Polim Med, 2017, 47 (2), pp. 101 - 106
Issue Date:: 2017-07

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Field	Value	Language
dc.contributor.author	Malipeddi, VR	en_US
dc.contributor.author	Awasthi, R	en_US
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159	en_US
dc.date.issued	2017-07	en_US
dc.identifier.citation	Polim Med, 2017, 47 (2), pp. 101 - 106	en_US
dc.identifier.issn	0370-0747	en_US
dc.identifier.uri	http://hdl.handle.net/10453/126705
dc.description.abstract	BACKGROUND: Ciprofloxacin is a broad-spectrum fluoroquinolone antibacterial drug to which most Gram-negative and many Gram-positive bacteria are highly susceptible. Fluoroquinolones are administered repeatedly, twice a day for 5 days, during the course of therapy. Hence, they require repeated administration. Ciprofloxacin qualifies as a drug candidate for a controlled-release drug delivery system. OBJECTIVES: The present work was aimed to develop ciprofloxacin hydrochloride-containing matrix tablets by the wet granulation method. MATERIAL AND METHODS: The tablets were prepared using EthocelTM 100 Premium and Eudragit® RS PO (Evonik Laboratory, Mumbai, India) as a rate-controlling polymer. Granular dioctyl phthalate (DCP) was used as a diluent. An isopropyl alcohol and dichloromethane (1:1) mixture was used as a granulating agent. The effect of the formulation variables on tablet performance was examined based on weight variation, hardness, friability, thickness, and drug release profiles. The results suggested that the tablets had good integrity. RESULTS: The tablets were stable for 18 months. Formulation F7 gave a linear release pattern up to 12 h. The release of ciprofloxacin from formulation F7 followed zero-order kinetics. The release mechanism was found to be diffusion-controlled as the Higuchi equation was obeyed. CONCLUSIONS: Ciprofloxacin hydrochloride-containing matrix tablets were prepared successfully. The tablets had good integrity and were found stable for 18 months.	en_US
dc.language	eng	en_US
dc.relation.ispartof	Polim Med	en_US
dc.relation.isbasedon	10.17219/pim/90020	en_US
dc.subject.mesh	Polymethacrylic Acids	en_US
dc.subject.mesh	Ciprofloxacin	en_US
dc.subject.mesh	Delayed-Action Preparations	en_US
dc.subject.mesh	Tablets	en_US
dc.subject.mesh	Excipients	en_US
dc.subject.mesh	Anti-Bacterial Agents	en_US
dc.subject.mesh	Diffusion	en_US
dc.subject.mesh	Kinetics	en_US
dc.subject.mesh	Chemistry, Pharmaceutical	en_US
dc.title	Formulation and evaluation of controlled-release matrix systems of ciprofloxacin.	en_US
dc.type	Journal Article
utslib.citation.volume	2	en_US
utslib.citation.volume	47	en_US
utslib.location.activity	Poland	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
utslib.copyright.status	closed_access
pubs.issue	2	en_US
pubs.publication-status	Published	en_US
pubs.volume	47	en_US

Abstract:

BACKGROUND: Ciprofloxacin is a broad-spectrum fluoroquinolone antibacterial drug to which most Gram-negative and many Gram-positive bacteria are highly susceptible. Fluoroquinolones are administered repeatedly, twice a day for 5 days, during the course of therapy. Hence, they require repeated administration. Ciprofloxacin qualifies as a drug candidate for a controlled-release drug delivery system. OBJECTIVES: The present work was aimed to develop ciprofloxacin hydrochloride-containing matrix tablets by the wet granulation method. MATERIAL AND METHODS: The tablets were prepared using EthocelTM 100 Premium and Eudragit® RS PO (Evonik Laboratory, Mumbai, India) as a rate-controlling polymer. Granular dioctyl phthalate (DCP) was used as a diluent. An isopropyl alcohol and dichloromethane (1:1) mixture was used as a granulating agent. The effect of the formulation variables on tablet performance was examined based on weight variation, hardness, friability, thickness, and drug release profiles. The results suggested that the tablets had good integrity. RESULTS: The tablets were stable for 18 months. Formulation F7 gave a linear release pattern up to 12 h. The release of ciprofloxacin from formulation F7 followed zero-order kinetics. The release mechanism was found to be diffusion-controlled as the Higuchi equation was obeyed. CONCLUSIONS: Ciprofloxacin hydrochloride-containing matrix tablets were prepared successfully. The tablets had good integrity and were found stable for 18 months.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/126705