Physicochemical and pharmacokinetic properties of polymeric films loaded with cisplatin for the treatment of malignant pleural mesothelioma

Sonvico, F; Barbieri, S; Colombo, P; Mucchino, C; Barocelli, E; Cantoni, AM; Cavazzoni, A; Petronini, PG; Rusca, M; Carbognani, P; Ampollini, L

Physicochemical and pharmacokinetic properties of polymeric films loaded with cisplatin for the treatment of malignant pleural mesothelioma

Barbieri, S Colombo, P Mucchino, C Barocelli, E Cantoni, AM Cavazzoni, A Petronini, PG Rusca, M Carbognani, P Ampollini, L

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Publication Type:: Journal Article
Citation:: Journal of Thoracic Disease, 2018, 10 pp. S194 - S206
Issue Date:: 2018-01-01

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Field	Value	Language
dc.contributor.author	Sonvico, F https://orcid.org/0000-0001-7372-1456	en_US
dc.contributor.author	Barbieri, S	en_US
dc.contributor.author	Colombo, P	en_US
dc.contributor.author	Mucchino, C	en_US
dc.contributor.author	Barocelli, E	en_US
dc.contributor.author	Cantoni, AM	en_US
dc.contributor.author	Cavazzoni, A	en_US
dc.contributor.author	Petronini, PG	en_US
dc.contributor.author	Rusca, M	en_US
dc.contributor.author	Carbognani, P	en_US
dc.contributor.author	Ampollini, L	en_US
dc.date.issued	2018-01-01	en_US
dc.identifier.citation	Journal of Thoracic Disease, 2018, 10 pp. S194 - S206	en_US
dc.identifier.issn	2072-1439	en_US
dc.identifier.uri	http://hdl.handle.net/10453/128333
dc.description.abstract	© Journal of Thoracic Disease. Background: Malignant mesothelioma is an invasive neoplasm arising from mesothelial surfaces of the pleural and peritoneal cavities. Mesothelioma treatment is unsatisfactory and recurrence is common. Here an innovative locoregional treatment for malignant pleural mesothelioma is presented. Methods: Chitosan- and hyaluronate-based films were loaded with 0.5% and 4% w/w cisplatin and were studied for their physicochemical, mechanical and drug release characteristics. The performance of the drug delivery systems was assessed in vitro on A549 cells and on an orthotopic model of MPM recurrence in rats. Results: Polysaccharide films produced were thin, flexible and resistant. Cisplatin was completely released from hyaluronic acid films within 96 hours, while drug release was found to be much more prolonged with chitosan films. The drug released from hyaluronate films was effective against A549 cell line, while for chitosan films the release was too slow to produce cytotoxicity. Similarly, cisplatin-loaded chitosan films in vivo released minimal quantities of cisplatin and induced inflammation and foreign body reaction. Cisplatinloaded hyaluronate acid films on the contrary were able to prevent tumor recurrence. The cisplatinloaded hyaluronate films provided higher Cmax and AUC compared to a solution of cisplatin administered intrapleurally, but did not show any sign of treatment related toxicity. Conclusions: Hyaluronate-based films appear as an optimal platform for the development of drug delivery systems suitable for the loco-regional post-surgical treatment of lung malignancies.	en_US
dc.relation.ispartof	Journal of Thoracic Disease	en_US
dc.relation.isbasedon	10.21037/jtd.2017.10.12	en_US
dc.title	Physicochemical and pharmacokinetic properties of polymeric films loaded with cisplatin for the treatment of malignant pleural mesothelioma	en_US
dc.type	Journal Article
utslib.citation.volume	10	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
utslib.for	1103 Clinical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	10	en_US

Abstract:

© Journal of Thoracic Disease. Background: Malignant mesothelioma is an invasive neoplasm arising from mesothelial surfaces of the pleural and peritoneal cavities. Mesothelioma treatment is unsatisfactory and recurrence is common. Here an innovative locoregional treatment for malignant pleural mesothelioma is presented. Methods: Chitosan- and hyaluronate-based films were loaded with 0.5% and 4% w/w cisplatin and were studied for their physicochemical, mechanical and drug release characteristics. The performance of the drug delivery systems was assessed in vitro on A549 cells and on an orthotopic model of MPM recurrence in rats. Results: Polysaccharide films produced were thin, flexible and resistant. Cisplatin was completely released from hyaluronic acid films within 96 hours, while drug release was found to be much more prolonged with chitosan films. The drug released from hyaluronate films was effective against A549 cell line, while for chitosan films the release was too slow to produce cytotoxicity. Similarly, cisplatin-loaded chitosan films in vivo released minimal quantities of cisplatin and induced inflammation and foreign body reaction. Cisplatinloaded hyaluronate acid films on the contrary were able to prevent tumor recurrence. The cisplatinloaded hyaluronate films provided higher Cmax and AUC compared to a solution of cisplatin administered intrapleurally, but did not show any sign of treatment related toxicity. Conclusions: Hyaluronate-based films appear as an optimal platform for the development of drug delivery systems suitable for the loco-regional post-surgical treatment of lung malignancies.

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http://hdl.handle.net/10453/128333