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Engineering of Biomaterials for Drug Delivery Systems: Beyond Polyethylene Glycol, 2018, pp. 255 - 272
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© 2018 Elsevier Ltd. All rights reserved. Poly(vinylpyrrolidone) (PVP) is one of the most commonly employed synthetic hydrophilic (nonionic) excipient in pharmaceutical formulations. Professor Walter Rappe and his team first developed this excipient during the 1930s and it is now gaining popularity due to its properties such as being nonantigenic, and hence avoiding the danger of infectious diseases inherent in blood. This chapter covers the basic introduction, physicochemical properties, synthesis, and the applications of PVP for its applications in pharmaceutical preparations such as solid, liquid, and semi-solid dosage forms including the PVP-based patented pharmaceutical products.
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