Comparison of percentage of syllables stuttered with parent-reported severity ratings as a primary outcome measure in clinical trials of early stuttering treatment

Onslow, M; Jones, M; O’Brian, S; Packman, A; Menzies, R; Lowe, R; Arnott, S; Bridgman, K; de Sonneville, C; Franken, MC

Comparison of percentage of syllables stuttered with parent-reported severity ratings as a primary outcome measure in clinical trials of early stuttering treatment

Onslow, M

Jones, M O’Brian, S

Packman, A

Menzies, R

Lowe, R

Arnott, S Bridgman, K de Sonneville, C Franken, MC

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Publication Type:: Journal Article
Citation:: Journal of Speech, Language, and Hearing Research, 2018, 61 (4), pp. 811 - 819
Issue Date:: 2018-04-01

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Field	Value	Language
dc.contributor.author	Onslow, M https://orcid.org/0000-0003-2629-2390	en_US
dc.contributor.author	Jones, M	en_US
dc.contributor.author	O’Brian, S https://orcid.org/0000-0002-0882-1909	en_US
dc.contributor.author	Packman, A https://orcid.org/0000-0001-7378-326X	en_US
dc.contributor.author	Menzies, R https://orcid.org/0000-0002-7589-960X	en_US
dc.contributor.author	Lowe, R https://orcid.org/0000-0003-3826-5306	en_US
dc.contributor.author	Arnott, S	en_US
dc.contributor.author	Bridgman, K	en_US
dc.contributor.author	de Sonneville, C	en_US
dc.contributor.author	Franken, MC	en_US
dc.date.available	2017-11-16	en_US
dc.date.issued	2018-04-01	en_US
dc.identifier.citation	Journal of Speech, Language, and Hearing Research, 2018, 61 (4), pp. 811 - 819	en_US
dc.identifier.issn	1092-4388	en_US
dc.identifier.uri	http://hdl.handle.net/10453/131329
dc.description.abstract	© 2018 American Speech-Language-Hearing Association. Purpose: This report investigates whether parent-reported stuttering severity ratings (SRs) provide similar estimates of effect size as percentage of syllables stuttered (%SS) for randomized trials of early stuttering treatment with preschool children. Method: Data sets from 3 randomized controlled trials of an early stuttering intervention were selected for analyses. Analyses included median changes and 95% confidence intervals per treatment group, Bland–Altman plots, analysis of covariance, and Spearman rho correlations. Results: Both SRs and %SS showed large effect sizes from pretreatment to follow-up, although correlations between the 2 measures were moderate at best. Absolute agreement between the 2 measures improved as percentage reduction of stuttering frequency and severity increased, probably due to innate measurement limitations for participants with low baseline severity. Analysis of covariance for the 3 trials showed consistent results. Conclusion: There is no statistical reason to favor %SS over parent-reported stuttering SRs as primary outcomes for clinical trials of early stuttering treatment. However, there are logistical reasons to favor parent-reported stuttering SRs. We conclude that parent-reported rating of the child’s typical stuttering severity for the week or month prior to each assessment is a justifiable alternative to %SS as a primary outcome measure in clinical trials of early stuttering treatment.	en_US
dc.relation.ispartof	Journal of Speech, Language, and Hearing Research	en_US
dc.relation.isbasedon	10.1044/2017_JSLHR-S-16-0448	en_US
dc.subject.classification	Speech-Language Pathology & Audiology	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Stuttering	en_US
dc.subject.mesh	Speech Production Measurement	en_US
dc.subject.mesh	Treatment Outcome	en_US
dc.subject.mesh	Severity of Illness Index	en_US
dc.subject.mesh	Analysis of Variance	en_US
dc.subject.mesh	Follow-Up Studies	en_US
dc.subject.mesh	Parents	en_US
dc.subject.mesh	Phonetics	en_US
dc.subject.mesh	Adolescent	en_US
dc.subject.mesh	Child	en_US
dc.subject.mesh	Outcome Assessment (Health Care)	en_US
dc.subject.mesh	Outcome Assessment, Health Care	en_US
dc.title	Comparison of percentage of syllables stuttered with parent-reported severity ratings as a primary outcome measure in clinical trials of early stuttering treatment	en_US
dc.type	Journal Article
utslib.citation.volume	4	en_US
utslib.citation.volume	61	en_US
utslib.for	1702 Cognitive Sciences	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	2004 Linguistics	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Strength - ASRC Australian Stuttering Research Centre
utslib.copyright.status	closed_access
pubs.issue	4	en_US
pubs.publication-status	Published	en_US
pubs.volume	61	en_US

Abstract:

© 2018 American Speech-Language-Hearing Association. Purpose: This report investigates whether parent-reported stuttering severity ratings (SRs) provide similar estimates of effect size as percentage of syllables stuttered (%SS) for randomized trials of early stuttering treatment with preschool children. Method: Data sets from 3 randomized controlled trials of an early stuttering intervention were selected for analyses. Analyses included median changes and 95% confidence intervals per treatment group, Bland–Altman plots, analysis of covariance, and Spearman rho correlations. Results: Both SRs and %SS showed large effect sizes from pretreatment to follow-up, although correlations between the 2 measures were moderate at best. Absolute agreement between the 2 measures improved as percentage reduction of stuttering frequency and severity increased, probably due to innate measurement limitations for participants with low baseline severity. Analysis of covariance for the 3 trials showed consistent results. Conclusion: There is no statistical reason to favor %SS over parent-reported stuttering SRs as primary outcomes for clinical trials of early stuttering treatment. However, there are logistical reasons to favor parent-reported stuttering SRs. We conclude that parent-reported rating of the child’s typical stuttering severity for the week or month prior to each assessment is a justifiable alternative to %SS as a primary outcome measure in clinical trials of early stuttering treatment.

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http://hdl.handle.net/10453/131329