Modeling of Pharmaceutical Biotransformation by Enriched Nitrifying Culture under Different Metabolic Conditions

Xu, Y; Chen, X; Yuan, Z; Ni, BJ

Modeling of Pharmaceutical Biotransformation by Enriched Nitrifying Culture under Different Metabolic Conditions

Xu, Y Chen, X Yuan, Z Ni, BJ

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Publication Type:: Journal Article
Citation:: Environmental Science and Technology, 2018, 52 (5), pp. 2835 - 2843
Issue Date:: 2018-03-06

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Field	Value	Language
dc.contributor.author	Xu, Y	en_US
dc.contributor.author	Chen, X	en_US
dc.contributor.author	Yuan, Z	en_US
dc.contributor.author	Ni, BJ https://orcid.org/0000-0002-1129-7837	en_US
dc.date.issued	2018-03-06	en_US
dc.identifier.citation	Environmental Science and Technology, 2018, 52 (5), pp. 2835 - 2843	en_US
dc.identifier.issn	0013-936X	en_US
dc.identifier.uri	http://hdl.handle.net/10453/132225
dc.description.abstract	© 2018 American Chemical Society. Pharmaceutical removal could be significantly enhanced through cometabolism during nitrification processes. To date, pharmaceutical biotransformation models have not considered the formation of transformation products associated with the metabolic type of microorganisms. Here we report a comprehensive model to describe and evaluate the biodegradation of pharmaceuticals and the formation of their biotransformation products by enriched nitrifying cultures. The biotransformation of parent compounds was linked to the microbial processes via cometabolism induced by ammonium-oxidizing bacteria (AOB) growth, metabolism by AOB, cometabolism by heterotrophs (HET) growth, and metabolism by HET in the model framework. The model was calibrated and validated using experimental data from pharmaceutical biodegradation experiments at realistic levels, taking two pharmaceuticals as examples, i.e., atenolol and acyclovir. Results demonstrated the good predictive performance of the established biotransformation model under different metabolic conditions, as well as the reliability of the established model in predicting different pharmaceutical biotransformations. The linear positive correlation between ammonia oxidation rate and pharmaceutical degradation rate confirmed the major role of cometabolism induced by AOB in the pharmaceutical removal. Dissolved oxygen was also revealed to be capable of regulating the pharmaceutical biotransformation cometabolically, and the substrate competition between ammonium and pharmaceuticals existed especially at high ammonium concentrations.	en_US
dc.relation.ispartof	Environmental Science and Technology	en_US
dc.relation.isbasedon	10.1021/acs.est.8b00705	en_US
dc.subject.classification	Environmental Sciences	en_US
dc.subject.mesh	Bacteria	en_US
dc.subject.mesh	Ammonia	en_US
dc.subject.mesh	Reproducibility of Results	en_US
dc.subject.mesh	Oxidation-Reduction	en_US
dc.subject.mesh	Biotransformation	en_US
dc.subject.mesh	Biodegradation, Environmental	en_US
dc.subject.mesh	Nitrification	en_US
dc.title	Modeling of Pharmaceutical Biotransformation by Enriched Nitrifying Culture under Different Metabolic Conditions	en_US
dc.type	Journal Article
utslib.citation.volume	5	en_US
utslib.citation.volume	52	en_US
utslib.for	090409 Wastewater Treatment Processes	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Civil and Environmental Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CTWW - Centre for Technology in Water and Wastewater Treatment
utslib.copyright.status	closed_access
pubs.issue	5	en_US
pubs.publication-status	Published	en_US
pubs.volume	52	en_US

Abstract:

© 2018 American Chemical Society. Pharmaceutical removal could be significantly enhanced through cometabolism during nitrification processes. To date, pharmaceutical biotransformation models have not considered the formation of transformation products associated with the metabolic type of microorganisms. Here we report a comprehensive model to describe and evaluate the biodegradation of pharmaceuticals and the formation of their biotransformation products by enriched nitrifying cultures. The biotransformation of parent compounds was linked to the microbial processes via cometabolism induced by ammonium-oxidizing bacteria (AOB) growth, metabolism by AOB, cometabolism by heterotrophs (HET) growth, and metabolism by HET in the model framework. The model was calibrated and validated using experimental data from pharmaceutical biodegradation experiments at realistic levels, taking two pharmaceuticals as examples, i.e., atenolol and acyclovir. Results demonstrated the good predictive performance of the established biotransformation model under different metabolic conditions, as well as the reliability of the established model in predicting different pharmaceutical biotransformations. The linear positive correlation between ammonia oxidation rate and pharmaceutical degradation rate confirmed the major role of cometabolism induced by AOB in the pharmaceutical removal. Dissolved oxygen was also revealed to be capable of regulating the pharmaceutical biotransformation cometabolically, and the substrate competition between ammonium and pharmaceuticals existed especially at high ammonium concentrations.

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http://hdl.handle.net/10453/132225