Positive association between hypertension and urinary bladder cancer: epidemiologic evidence involving 79,236 propensity score-matched individuals.

Kok, VC; Zhang, H-W; Lin, C-T; Huang, S-C; Wu, M-F

Positive association between hypertension and urinary bladder cancer: epidemiologic evidence involving 79,236 propensity score-matched individuals.

Kok, VC Zhang, H-W Lin, C-T

Huang, S-C Wu, M-F

Permalink

Publication Type:: Journal Article
Citation:: Ups J Med Sci, 2018, 123 (2), pp. 109 - 115
Issue Date:: 2018-06

Closed Access

	Filename	Description	Size
	Positive association between hypertension and urinary bladder cancer: epidemiologic evidence involving 79,236 propensity score-matched individuals.pdf	Accepted Manuscript Version	1.05 MB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Kok, VC	en_US
dc.contributor.author	Zhang, H-W	en_US
dc.contributor.author	Lin, C-T https://orcid.org/0000-0001-8371-8197	en_US
dc.contributor.author	Huang, S-C	en_US
dc.contributor.author	Wu, M-F	en_US
dc.date.issued	2018-06	en_US
dc.identifier.citation	Ups J Med Sci, 2018, 123 (2), pp. 109 - 115	en_US
dc.identifier.uri	http://hdl.handle.net/10453/132498
dc.description.abstract	INTRODUCTION: We hypothesized that hypertensive patients harbor a higher risk of urinary bladder (UB) cancer. MATERIAL AND METHODS: We performed a population-based cohort study on adults using a National Health Insurance Research Database (NHIRD) dataset. Hypertension and comparison non-hypertensive (COMP) groups comprising 39,618 patients each were propensity score-matched by age, sex, index date, and medical comorbidities. The outcome was incident UB cancer validated using procedure codes. We constructed multivariable Cox models to derive adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs). Cumulative incidence was compared using a log-rank test. RESULTS: During a total follow-up duration of 380,525 and 372,020 person-years in the hypertension and COMP groups, 248 and 186 patients developed UB cancer, respectively, representing a 32% increase in the risk (aHR, 1.32; 95% CI, 1.09-1.60). Hypertensive women harbored a significantly increased risk of UB cancer (aHR, 1.55; 95% CI, 1.12-2.13) compared with non-hypertensive women, whereas men with hypertension had a statistically non-significant increased risk (aHR, 1.22; 95% CI, 0.96-1.55). The sensitivity analysis demonstrated that the increased risk was sustained throughout different follow-up durations for the entire cohort; a statistical increase in the risk was also noted among hypertensive men. CONCLUSION: This nationwide population-based propensity score-matched cohort study supports a positive association between hypertension and subsequent UB cancer development.	en_US
dc.language	eng	en_US
dc.relation.ispartof	Ups J Med Sci	en_US
dc.relation.isbasedon	10.1080/03009734.2018.1473534	en_US
dc.subject.classification	General & Internal Medicine	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Hypertension	en_US
dc.subject.mesh	Treatment Outcome	en_US
dc.subject.mesh	Incidence	en_US
dc.subject.mesh	Multivariate Analysis	en_US
dc.subject.mesh	Proportional Hazards Models	en_US
dc.subject.mesh	Risk Factors	en_US
dc.subject.mesh	Sensitivity and Specificity	en_US
dc.subject.mesh	Longitudinal Studies	en_US
dc.subject.mesh	Follow-Up Studies	en_US
dc.subject.mesh	Comorbidity	en_US
dc.subject.mesh	Algorithms	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Urinary Bladder Neoplasms	en_US
dc.subject.mesh	Propensity Score	en_US
dc.subject.mesh	Kaplan-Meier Estimate	en_US
dc.title	Positive association between hypertension and urinary bladder cancer: epidemiologic evidence involving 79,236 propensity score-matched individuals.	en_US
dc.type	Journal Article
utslib.citation.volume	2	en_US
utslib.citation.volume	123	en_US
utslib.location.activity	England	en_US
utslib.for	1112 Oncology and Carcinogenesis	en_US
utslib.for	11 Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Computer Science
pubs.organisational-group	/University of Technology Sydney/Strength - CAI - Centre for Artificial Intelligence
utslib.copyright.status	closed_access
pubs.issue	2	en_US
pubs.publication-status	Published	en_US
pubs.volume	123	en_US

Abstract:

INTRODUCTION: We hypothesized that hypertensive patients harbor a higher risk of urinary bladder (UB) cancer. MATERIAL AND METHODS: We performed a population-based cohort study on adults using a National Health Insurance Research Database (NHIRD) dataset. Hypertension and comparison non-hypertensive (COMP) groups comprising 39,618 patients each were propensity score-matched by age, sex, index date, and medical comorbidities. The outcome was incident UB cancer validated using procedure codes. We constructed multivariable Cox models to derive adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs). Cumulative incidence was compared using a log-rank test. RESULTS: During a total follow-up duration of 380,525 and 372,020 person-years in the hypertension and COMP groups, 248 and 186 patients developed UB cancer, respectively, representing a 32% increase in the risk (aHR, 1.32; 95% CI, 1.09-1.60). Hypertensive women harbored a significantly increased risk of UB cancer (aHR, 1.55; 95% CI, 1.12-2.13) compared with non-hypertensive women, whereas men with hypertension had a statistically non-significant increased risk (aHR, 1.22; 95% CI, 0.96-1.55). The sensitivity analysis demonstrated that the increased risk was sustained throughout different follow-up durations for the entire cohort; a statistical increase in the risk was also noted among hypertensive men. CONCLUSION: This nationwide population-based propensity score-matched cohort study supports a positive association between hypertension and subsequent UB cancer development.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/132498