Quantitative assessment of the mechanical properties of prostate tissue with optical coherence elastography

Ling, Y; Li, C; Zhou, K; Guan, G; Lang, S; McGloin, D; Nabi, G; Huang, Z

Quantitative assessment of the mechanical properties of prostate tissue with optical coherence elastography

Ling, Y Li, C Zhou, K Guan, G Lang, S McGloin, D

Nabi, G Huang, Z

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Publication Type:: Conference Proceeding
Citation:: Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 2018, 10468
Issue Date:: 2018-01-01

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Field	Value	Language
dc.contributor.author	Ling, Y	en_US
dc.contributor.author	Li, C	en_US
dc.contributor.author	Zhou, K	en_US
dc.contributor.author	Guan, G	en_US
dc.contributor.author	Lang, S	en_US
dc.contributor.author	McGloin, D https://orcid.org/0000-0002-0075-4481	en_US
dc.contributor.author	Nabi, G	en_US
dc.contributor.author	Huang, Z	en_US
dc.date.issued	2018-01-01	en_US
dc.identifier.citation	Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 2018, 10468	en_US
dc.identifier.isbn	9781510614215	en_US
dc.identifier.issn	1605-7422	en_US
dc.identifier.uri	http://hdl.handle.net/10453/133731
dc.description.abstract	© COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only. Prostate cancer (PCa) is a heterogeneous disease with multifocal origin. In current clinical care, the Gleason scoring system is the well-established diagnosis by microscopic evaluation of the tissue from trans-rectal ultrasound (TRUS) guided biopsies. Nevertheless, the sensitivity and specificity in detecting PCa can range from 40 to 50% for conventional TRUS B-mode imaging. Tissue elasticity is associated with the disease progression and elastography technique has recently shown promise in aiding PCa diagnosis. However, many cancer foci in the prostate gland has very small size less than 1 mm and those detected by medical elastography were larger than 2 mm. Hereby, we introduce optical coherence elastography (OCE) to quantify the prostate stiffness with high resolution in the magnitude of 10 μm. Following our feasibility study of 10 patients reported previously, we recruited 60 more patients undergoing 12-core TRUS guided biopsies for suspected PCa with a total of 720 biopsies. The stiffness of cancer tissue was approximately 57.63% higher than that of benign ones. Using histology as reference standard and cut-off threshold of 600kPa, the data analysis showed sensitivity and specificity of 89.6% and 99.8% respectively. The method also demonstrated potential in characterising different grades of PCa based on the change of tissue morphology and quantitative mechanical properties. In conclusion, quantitative OCE can be a reliable technique to identify PCa lesion and differentiate indolent from aggressive cancer.	en_US
dc.relation.ispartof	Progress in Biomedical Optics and Imaging - Proceedings of SPIE	en_US
dc.relation.isbasedon	10.1117/12.2288485	en_US
dc.title	Quantitative assessment of the mechanical properties of prostate tissue with optical coherence elastography	en_US
dc.type	Conference Proceeding
utslib.citation.volume	10468	en_US
utslib.for	0903 Biomedical Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
utslib.copyright.status	open_access
pubs.publication-status	Published	en_US
pubs.volume	10468	en_US

Abstract:

© COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only. Prostate cancer (PCa) is a heterogeneous disease with multifocal origin. In current clinical care, the Gleason scoring system is the well-established diagnosis by microscopic evaluation of the tissue from trans-rectal ultrasound (TRUS) guided biopsies. Nevertheless, the sensitivity and specificity in detecting PCa can range from 40 to 50% for conventional TRUS B-mode imaging. Tissue elasticity is associated with the disease progression and elastography technique has recently shown promise in aiding PCa diagnosis. However, many cancer foci in the prostate gland has very small size less than 1 mm and those detected by medical elastography were larger than 2 mm. Hereby, we introduce optical coherence elastography (OCE) to quantify the prostate stiffness with high resolution in the magnitude of 10 μm. Following our feasibility study of 10 patients reported previously, we recruited 60 more patients undergoing 12-core TRUS guided biopsies for suspected PCa with a total of 720 biopsies. The stiffness of cancer tissue was approximately 57.63% higher than that of benign ones. Using histology as reference standard and cut-off threshold of 600kPa, the data analysis showed sensitivity and specificity of 89.6% and 99.8% respectively. The method also demonstrated potential in characterising different grades of PCa based on the change of tissue morphology and quantitative mechanical properties. In conclusion, quantitative OCE can be a reliable technique to identify PCa lesion and differentiate indolent from aggressive cancer.

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http://hdl.handle.net/10453/133731