Antibacterial and antioxidant potential of biosynthesized copper nanoparticles mediated through Cissus arnotiana plant extract

Rajeshkumar, S; Menon, S; Venkat Kumar, S; Tambuwala, MM; Bakshi, HA; Mehta, M; Satija, S; Gupta, G; Chellappan, DK; Thangavelu, L; Dua, K

Antibacterial and antioxidant potential of biosynthesized copper nanoparticles mediated through Cissus arnotiana plant extract

Rajeshkumar, S Menon, S Venkat Kumar, S Tambuwala, MM Bakshi, HA Mehta, M Satija, S Gupta, G Chellappan, DK Thangavelu, L Dua, K

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Publication Type:: Journal Article
Citation:: Journal of Photochemistry and Photobiology B: Biology, 2019, 197
Issue Date:: 2019-08-01

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Field	Value	Language
dc.contributor.author	Rajeshkumar, S	en_US
dc.contributor.author	Menon, S	en_US
dc.contributor.author	Venkat Kumar, S	en_US
dc.contributor.author	Tambuwala, MM	en_US
dc.contributor.author	Bakshi, HA	en_US
dc.contributor.author	Mehta, M	en_US
dc.contributor.author	Satija, S	en_US
dc.contributor.author	Gupta, G	en_US
dc.contributor.author	Chellappan, DK	en_US
dc.contributor.author	Thangavelu, L	en_US
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159	en_US
dc.date.available	2019-06-05	en_US
dc.date.issued	2019-08-01	en_US
dc.identifier.citation	Journal of Photochemistry and Photobiology B: Biology, 2019, 197	en_US
dc.identifier.issn	1011-1344	en_US
dc.identifier.uri	http://hdl.handle.net/10453/134881
dc.description.abstract	© 2019 Elsevier B.V. Environment friendly methods for the synthesis of copper nanoparticles have become a valuable trend in the current scenario. The utilization of phytochemicals from plant extracts has become a unique technology for the synthesis of nanoparticles, as they possess dual nature of reducing and capping agents to the nanoparticles. In the present investigation we have synthesized copper nanoparticles (CuNPs) using a rare medicinal plant Cissus arnotiana and evaluated their antibacterial activity against gram negative and gram positive bacteria. The morphology and characterization of the synthesized CuNPs were studied and done using UV-Visible spectroscopy at a wavelength range of 350–380 nm. XRD studies were performed for analyzing the crystalline nature; SEM and TEM for evaluating the spherical shape within the size range of 60–90 nm and AFM was performed to check the surface roughness. The biosynthesized CuNPs showed better antibacterial activity against the gram-negative bacteria, E. coli with an inhibition zone of 22.20 ± 0.16 mm at 75 μg/ml. The antioxidant property observed was comparatively equal with the standard antioxidant agent ascorbic acid at a maximum concentration of 40 μg/ ml. This is the first study reported on C. arnotiana mediated biosynthesis of copper nanoparticles, where we believe that the findings can pave way for a new direction in the field of nanotechnology and nanomedicine where there is a significant potential for antibacterial and antioxidant activities. We predict that, these could lead to an exponential increase in the field of biomedical applications, with the utilization of green synthesized CuNPs, due to its remarkable properties. The highest antibacterial property was observed with gram-negative strains mainly, E. coli, due to its thin peptidoglycan layer and electrostatic interactions between the bacterial cell wall and CuNPs surfaces. Hence, CuNPs can be potent therapeutic agents in several biomedical applications, which are yet to be explored in the near future.	en_US
dc.relation.ispartof	Journal of Photochemistry and Photobiology B: Biology	en_US
dc.relation.isbasedon	10.1016/j.jphotobiol.2019.111531	en_US
dc.subject.classification	Biophysics	en_US
dc.subject.mesh	Gram-Negative Bacteria	en_US
dc.subject.mesh	Gram-Positive Bacteria	en_US
dc.subject.mesh	Cissus	en_US
dc.subject.mesh	Copper	en_US
dc.subject.mesh	Plant Extracts	en_US
dc.subject.mesh	Antioxidants	en_US
dc.subject.mesh	Anti-Bacterial Agents	en_US
dc.subject.mesh	Microbial Sensitivity Tests	en_US
dc.subject.mesh	Metal Nanoparticles	en_US
dc.subject.mesh	Static Electricity	en_US
dc.subject.mesh	Green Chemistry Technology	en_US
dc.title	Antibacterial and antioxidant potential of biosynthesized copper nanoparticles mediated through Cissus arnotiana plant extract	en_US
dc.type	Journal Article
utslib.citation.volume	197	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
utslib.for	0299 Other Physical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	197	en_US

Abstract:

© 2019 Elsevier B.V. Environment friendly methods for the synthesis of copper nanoparticles have become a valuable trend in the current scenario. The utilization of phytochemicals from plant extracts has become a unique technology for the synthesis of nanoparticles, as they possess dual nature of reducing and capping agents to the nanoparticles. In the present investigation we have synthesized copper nanoparticles (CuNPs) using a rare medicinal plant Cissus arnotiana and evaluated their antibacterial activity against gram negative and gram positive bacteria. The morphology and characterization of the synthesized CuNPs were studied and done using UV-Visible spectroscopy at a wavelength range of 350–380 nm. XRD studies were performed for analyzing the crystalline nature; SEM and TEM for evaluating the spherical shape within the size range of 60–90 nm and AFM was performed to check the surface roughness. The biosynthesized CuNPs showed better antibacterial activity against the gram-negative bacteria, E. coli with an inhibition zone of 22.20 ± 0.16 mm at 75 μg/ml. The antioxidant property observed was comparatively equal with the standard antioxidant agent ascorbic acid at a maximum concentration of 40 μg/ ml. This is the first study reported on C. arnotiana mediated biosynthesis of copper nanoparticles, where we believe that the findings can pave way for a new direction in the field of nanotechnology and nanomedicine where there is a significant potential for antibacterial and antioxidant activities. We predict that, these could lead to an exponential increase in the field of biomedical applications, with the utilization of green synthesized CuNPs, due to its remarkable properties. The highest antibacterial property was observed with gram-negative strains mainly, E. coli, due to its thin peptidoglycan layer and electrostatic interactions between the bacterial cell wall and CuNPs surfaces. Hence, CuNPs can be potent therapeutic agents in several biomedical applications, which are yet to be explored in the near future.

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http://hdl.handle.net/10453/134881