Attitude towards and factors affecting uptake of population-based BRCA testing in the Ashkenazi Jewish population: a cohort study
Manchanda, R
Burnell, M
Gaba, F
Sanderson, S
Loggenberg, K
Gessler, S
Wardle, J
Side, L
Desai, R
Brady, AF
Dorkins, H
Wallis, Y
Chapman, C
Jacobs, C
Tomlinson, I
Beller, U
Menon, U
Jacobs, I
Tomlinson, I
Beller, U
Menon, U
Jacobs, I
- Publication Type:
- Journal Article
- Citation:
- BJOG: An International Journal of Obstetrics and Gynaecology, 2019, 126 (6), pp. 784 - 794
- Issue Date:
- 2019-05-01
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| Attitude towards and factors affecting uptake of population‐based BRCA testing in the Ashkenazi Jewish population a cohort study.pdf | Published Version | 197.42 kB |
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© 2019 Royal College of Obstetricians and Gynaecologists Objective: To evaluate factors affecting unselected population-based BRCA testing in Ashkenazi Jews (AJ). Design: Cohort-study set within recruitment to the GCaPPS trial (ISRCTN73338115). Setting: North London AJ population. Population or sample: Ashkenazi Jews women/men >18 years, recruited through self-referral. Methods: Ashkenazi Jews women/men underwent pre-test counselling for BRCA testing through recruitment clinics (clusters). Consenting individuals provided blood samples for BRCA testing. Data were collected on socio-demographic/family history/knowledge/psychological well-being along with benefits/risks/cultural influences (18-item questionnaire measuring ‘attitude’). Four-item Likert-scales analysed initial ‘interest’ and ‘intention-to-test’ pre-counselling. Uni- and multivariable logistic regression models evaluated factors affecting uptake/interest/intention to undergo BRCA testing. Statistical inference was based on cluster robust standard errors and joint Wald tests for significance. Item-Response Theory and graded-response models modelled responses to 18-item questionnaire. Main outcome measures: Interest, intention, uptake, attitude towards BRCA testing. Results: A total of 935 individuals (women = 67%/men = 33%; mean age = 53.8 (SD = 15.02) years) underwent pre-test genetic-counselling. During the pre-counselling, 96% expressed interest in and 60% indicated a clear intention to undergo BRCA testing. Subsequently, 88% opted for BRCA testing. BRCA-related knowledge (P = 0.013) and degree-level education (P = 0.01) were positively and negatively (respectively) associated with intention-to-test. Being married/cohabiting had four-fold higher odds for BRCA testing uptake (P = 0.009). Perceived benefits were associated with higher pre-counselling odds for interest in and intention to undergo BRCA testing. Reduced uncertainty/reassurance were the most important factors contributing to decision-making. Increased importance/concern towards risks/limitations (confidentiality/insurance/emotional impact/inability to prevent cancer/marriage ability/ethnic focus/stigmatisation) were significantly associated with lower odds of uptake of BRCA testing, and discriminated between acceptors and decliners. Male gender/degree-level education (P = 0.001) had weaker correlations, whereas having children showed stronger (P = 0.005) associations with attitudes towards BRCA testing. Conclusions: BRCA testing in the AJ population has high acceptability. Pre-test counselling increases awareness of disadvantages/limitations of BRCA testing, influencing final cost-benefit perception and decision-making on undergoing testing. Tweetable abstract: BRCA testing in Ashkenazi Jews has high acceptability and uptake. Pre-test counselling facilitates informed decision-making.
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