Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study
Larsson, SC
Traylor, M
Burgess, S
Boncoraglio, GB
Jern, C
Michaëlsson, K
Markus, HS
Malik, R
Chauhan, G
Sargurupremraj, M
Okada, Y
Mishra, A
Rutten-Jacobs, L
Giese, AK
Van Der Laan, SW
Gretarsdottir, S
Anderson, CD
Chong, M
Adams, HHH
Ago, T
Almgren, P
Amouyel, P
Ay, H
Bartz, RM
Benavente, OR
Bevan, S
Brown, RD
Butterworth, AS
Carrera, C
Carty, CL
Chasman, DI
Chen, WM
Cole, JW
Correa, A
Cotlarciuc, I
Cruchaga, C
Danesh, J
De Bakker, PIW
Destefano, AL
Hoed, MD
Duan, Q
Engelter, ST
Falcone, GJ
Gottesman, RF
Grewal, RP
Gudnason, V
Gustafsson, S
Haessler, J
Harris, TB
Hassan, A
Havulinna, AS
Heckbert, SR
Holliday, EG
Howard, G
Hsu, FC
Hyacinth, HI
Ikram, MA
Ingelsson, E
Irvin, MR
Jian, X
Jiménez-Conde, J
Johnson, JA
Jukema, JW
Kanai, M
Keene, KL
Kissela, BM
Kleindorfer, DO
Kooperberg, C
Kubo, M
Lange, LA
Langefeld, CD
Langenberg, C
Launer, LJ
Lee, JM
Lemmens, R
Leys, D
Lewis, CM
Lin, WY
Lindgren, AG
Lorentzen, E
Magnusson, PK
Maguire, J
Manichaikul, A
McArdle, PF
Meschia, JF
Mitchell, BD
Mosley, TH
Nalls, MA
Ninomiya, T
O'Donnell, MJ
Psaty, BM
Pulit, SL
Rannikmäe, K
Reiner, AP
Rexrode, KM
Rice, K
Rich, SS
Ridker, PM
Rost, NS
Rothwell, PM
- Publication Type:
- Journal Article
- Citation:
- Neurology, 2019, 92 (9), pp. E944 - E950
- Issue Date:
- 2019-02-26
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Larsson, SC | en_US |
dc.contributor.author | Traylor, M | en_US |
dc.contributor.author | Burgess, S | en_US |
dc.contributor.author | Boncoraglio, GB | en_US |
dc.contributor.author | Jern, C | en_US |
dc.contributor.author | Michaëlsson, K | en_US |
dc.contributor.author | Markus, HS | en_US |
dc.contributor.author | Malik, R | en_US |
dc.contributor.author | Chauhan, G | en_US |
dc.contributor.author | Sargurupremraj, M | en_US |
dc.contributor.author | Okada, Y | en_US |
dc.contributor.author | Mishra, A | en_US |
dc.contributor.author | Rutten-Jacobs, L | en_US |
dc.contributor.author | Giese, AK | en_US |
dc.contributor.author | Van Der Laan, SW | en_US |
dc.contributor.author | Gretarsdottir, S | en_US |
dc.contributor.author | Anderson, CD | en_US |
dc.contributor.author | Chong, M | en_US |
dc.contributor.author | Adams, HHH | en_US |
dc.contributor.author | Ago, T | en_US |
dc.contributor.author | Almgren, P | en_US |
dc.contributor.author | Amouyel, P | en_US |
dc.contributor.author | Ay, H | en_US |
dc.contributor.author | Bartz, RM | en_US |
dc.contributor.author | Benavente, OR | en_US |
dc.contributor.author | Bevan, S | en_US |
dc.contributor.author | Brown, RD | en_US |
dc.contributor.author | Butterworth, AS | en_US |
dc.contributor.author | Carrera, C | en_US |
dc.contributor.author | Carty, CL | en_US |
dc.contributor.author | Chasman, DI | en_US |
dc.contributor.author | Chen, WM | en_US |
dc.contributor.author | Cole, JW | en_US |
dc.contributor.author | Correa, A | en_US |
dc.contributor.author | Cotlarciuc, I | en_US |
dc.contributor.author | Cruchaga, C | en_US |
dc.contributor.author | Danesh, J | en_US |
dc.contributor.author | De Bakker, PIW | en_US |
dc.contributor.author | Destefano, AL | en_US |
dc.contributor.author | Hoed, MD | en_US |
dc.contributor.author | Duan, Q | en_US |
dc.contributor.author | Engelter, ST | en_US |
dc.contributor.author | Falcone, GJ | en_US |
dc.contributor.author | Gottesman, RF | en_US |
dc.contributor.author | Grewal, RP | en_US |
dc.contributor.author | Gudnason, V | en_US |
dc.contributor.author | Gustafsson, S | en_US |
dc.contributor.author | Haessler, J | en_US |
dc.contributor.author | Harris, TB | en_US |
dc.contributor.author | Hassan, A | en_US |
dc.contributor.author | Havulinna, AS | en_US |
dc.contributor.author | Heckbert, SR | en_US |
dc.contributor.author | Holliday, EG | en_US |
dc.contributor.author | Howard, G | en_US |
dc.contributor.author | Hsu, FC | en_US |
dc.contributor.author | Hyacinth, HI | en_US |
dc.contributor.author | Ikram, MA | en_US |
dc.contributor.author | Ingelsson, E | en_US |
dc.contributor.author | Irvin, MR | en_US |
dc.contributor.author | Jian, X | en_US |
dc.contributor.author | Jiménez-Conde, J | en_US |
dc.contributor.author | Johnson, JA | en_US |
dc.contributor.author | Jukema, JW | en_US |
dc.contributor.author | Kanai, M | en_US |
dc.contributor.author | Keene, KL | en_US |
dc.contributor.author | Kissela, BM | en_US |
dc.contributor.author | Kleindorfer, DO | en_US |
dc.contributor.author | Kooperberg, C | en_US |
dc.contributor.author | Kubo, M | en_US |
dc.contributor.author | Lange, LA | en_US |
dc.contributor.author | Langefeld, CD | en_US |
dc.contributor.author | Langenberg, C | en_US |
dc.contributor.author | Launer, LJ | en_US |
dc.contributor.author | Lee, JM | en_US |
dc.contributor.author | Lemmens, R | en_US |
dc.contributor.author | Leys, D | en_US |
dc.contributor.author | Lewis, CM | en_US |
dc.contributor.author | Lin, WY | en_US |
dc.contributor.author | Lindgren, AG | en_US |
dc.contributor.author | Lorentzen, E | en_US |
dc.contributor.author | Magnusson, PK | en_US |
dc.contributor.author |
Maguire, J https://orcid.org/0000-0001-5722-8311 |
en_US |
dc.contributor.author | Manichaikul, A | en_US |
dc.contributor.author | McArdle, PF | en_US |
dc.contributor.author | Meschia, JF | en_US |
dc.contributor.author | Mitchell, BD | en_US |
dc.contributor.author | Mosley, TH | en_US |
dc.contributor.author | Nalls, MA | en_US |
dc.contributor.author | Ninomiya, T | en_US |
dc.contributor.author | O'Donnell, MJ | en_US |
dc.contributor.author | Psaty, BM | en_US |
dc.contributor.author | Pulit, SL | en_US |
dc.contributor.author | Rannikmäe, K | en_US |
dc.contributor.author | Reiner, AP | en_US |
dc.contributor.author | Rexrode, KM | en_US |
dc.contributor.author | Rice, K | en_US |
dc.contributor.author | Rich, SS | en_US |
dc.contributor.author | Ridker, PM | en_US |
dc.contributor.author | Rost, NS | en_US |
dc.contributor.author | Rothwell, PM | en_US |
dc.date.available | 2018-10-24 | en_US |
dc.date.issued | 2019-02-26 | en_US |
dc.identifier.citation | Neurology, 2019, 92 (9), pp. E944 - E950 | en_US |
dc.identifier.issn | 0028-3878 | en_US |
dc.identifier.uri | http://hdl.handle.net/10453/135706 | |
dc.description.abstract | © 2019 American Academy of Neurology. ObjectiveTo determine whether serum magnesium and calcium concentrations are causally associated with ischemic stroke or any of its subtypes using the mendelian randomization approach.MethodsAnalyses were conducted using summary statistics data for 13 single-nucleotide polymorphisms robustly associated with serum magnesium (n = 6) or serum calcium (n = 7) concentrations. The corresponding data for ischemic stroke were obtained from the MEGASTROKE consortium (34,217 cases and 404,630 noncases).ResultsIn standard mendelian randomization analysis, the odds ratios for each 0.1 mmol/L (about 1 SD) increase in genetically predicted serum magnesium concentrations were 0.78 (95% confidence interval [CI] 0.69-0.89; p = 1.3 × 10-4) for all ischemic stroke, 0.63 (95% CI 0.50-0.80; p = 1.6 × 10-4) for cardioembolic stroke, and 0.60 (95% CI 0.44-0.82; p = 0.001) for large artery stroke; there was no association with small vessel stroke (odds ratio 0.90, 95% CI 0.67-1.20; p = 0.46). Only the association with cardioembolic stroke was robust in sensitivity analyses. There was no association of genetically predicted serum calcium concentrations with all ischemic stroke (per 0.5 mg/dL [about 1 SD] increase in serum calcium: odds ratio 1.03, 95% CI 0.88-1.21) or with any subtype.ConclusionsThis study found that genetically higher serum magnesium concentrations are associated with a reduced risk of cardioembolic stroke but found no significant association of genetically higher serum calcium concentrations with any ischemic stroke subtype. | en_US |
dc.relation.ispartof | Neurology | en_US |
dc.relation.isbasedon | 10.1212/WNL.0000000000007001 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject.classification | Neurology & Neurosurgery | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Brain Ischemia | en_US |
dc.subject.mesh | Intracranial Embolism | en_US |
dc.subject.mesh | Calcium | en_US |
dc.subject.mesh | Magnesium | en_US |
dc.subject.mesh | Polymorphism, Single Nucleotide | en_US |
dc.subject.mesh | Stroke | en_US |
dc.subject.mesh | Mendelian Randomization Analysis | en_US |
dc.title | Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study | en_US |
dc.type | Journal Article | |
utslib.citation.volume | 9 | en_US |
utslib.citation.volume | 92 | en_US |
utslib.for | 1103 Clinical Sciences | en_US |
utslib.for | 1109 Neurosciences | en_US |
utslib.for | 1702 Cognitive Sciences | en_US |
pubs.embargo.period | Not known | en_US |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Health | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Health/Nursing | |
utslib.copyright.status | open_access | * |
pubs.declined | 2019-09-06T11:14:29.98+1000 | |
pubs.issue | 9 | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 92 | en_US |
Abstract:
© 2019 American Academy of Neurology. ObjectiveTo determine whether serum magnesium and calcium concentrations are causally associated with ischemic stroke or any of its subtypes using the mendelian randomization approach.MethodsAnalyses were conducted using summary statistics data for 13 single-nucleotide polymorphisms robustly associated with serum magnesium (n = 6) or serum calcium (n = 7) concentrations. The corresponding data for ischemic stroke were obtained from the MEGASTROKE consortium (34,217 cases and 404,630 noncases).ResultsIn standard mendelian randomization analysis, the odds ratios for each 0.1 mmol/L (about 1 SD) increase in genetically predicted serum magnesium concentrations were 0.78 (95% confidence interval [CI] 0.69-0.89; p = 1.3 × 10-4) for all ischemic stroke, 0.63 (95% CI 0.50-0.80; p = 1.6 × 10-4) for cardioembolic stroke, and 0.60 (95% CI 0.44-0.82; p = 0.001) for large artery stroke; there was no association with small vessel stroke (odds ratio 0.90, 95% CI 0.67-1.20; p = 0.46). Only the association with cardioembolic stroke was robust in sensitivity analyses. There was no association of genetically predicted serum calcium concentrations with all ischemic stroke (per 0.5 mg/dL [about 1 SD] increase in serum calcium: odds ratio 1.03, 95% CI 0.88-1.21) or with any subtype.ConclusionsThis study found that genetically higher serum magnesium concentrations are associated with a reduced risk of cardioembolic stroke but found no significant association of genetically higher serum calcium concentrations with any ischemic stroke subtype.
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