Efficacy of co-administration of modified apple polysaccharide and probiotics in guar gum-Eudragit S100 based mesalamine mini tablets: A novel approach in treating ulcerative colitis

Mohanta, S; Singh, SK; Kumar, B; Gulati, M; Kumar, R; Yadav, AK; Wadhwa, S; Jyoti, J; Som, S; Dua, K; Pandey, NK

Efficacy of co-administration of modified apple polysaccharide and probiotics in guar gum-Eudragit S100 based mesalamine mini tablets: A novel approach in treating ulcerative colitis

Mohanta, S Singh, SK Kumar, B Gulati, M Kumar, R Yadav, AK Wadhwa, S Jyoti, J Som, S Dua, K

Pandey, NK

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Publication Type:: Journal Article
Citation:: International Journal of Biological Macromolecules, 2019, 126 pp. 427 - 435
Issue Date:: 2019-04-01

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Field	Value	Language
dc.contributor.author	Mohanta, S	en_US
dc.contributor.author	Singh, SK	en_US
dc.contributor.author	Kumar, B	en_US
dc.contributor.author	Gulati, M	en_US
dc.contributor.author	Kumar, R	en_US
dc.contributor.author	Yadav, AK	en_US
dc.contributor.author	Wadhwa, S	en_US
dc.contributor.author	Jyoti, J	en_US
dc.contributor.author	Som, S	en_US
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159	en_US
dc.contributor.author	Pandey, NK	en_US
dc.date.available	2018-12-16	en_US
dc.date.issued	2019-04-01	en_US
dc.identifier.citation	International Journal of Biological Macromolecules, 2019, 126 pp. 427 - 435	en_US
dc.identifier.issn	0141-8130	en_US
dc.identifier.uri	http://hdl.handle.net/10453/136278
dc.description.abstract	© 2018 Elsevier B.V. Modified Apple Polysaccharide (MAP) has been reported to cure colorectal diseases by up-regulating apoptosis and down regulating metastasis. In the present study, mesalamine (MES) and MAP mini tablets have been prepared and co-administered with probiotics to provide site specific release of drug. Probiotics along with MAP, which acts as a prebiotic would replenish the colonic microflora that have been compromised due to colorectal pathology. MES mini tablets were prepared keeping guar gum in the core and coating them with Eudragit S100 and guar gum. The optimized batch was explored for its curative potential on acetic acid induced ulcerative colitis (UC) in rat model with and without administration of probiotic and MAP. The results revealed that the rats treated with the combination of MAP and MES mini tablets along with probiotics show maximum curative potential. It was also observed that MAP mini tablets show better curative potential as compared to probiotics. The results of disease activity index, macroscopic scoring, antioxidant studies, tumour alpha and histopathological examination suggested that the rats treated with combination of MES-MAP mini tablets and probiotics have maximum therapeutic effect followed by MES mini tablets alone, MAP mini tablets alone and probiotics.	en_US
dc.relation.ispartof	International Journal of Biological Macromolecules	en_US
dc.relation.isbasedon	10.1016/j.ijbiomac.2018.12.154	en_US
dc.subject.classification	Polymers	en_US
dc.subject.mesh	Colon	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Rats, Sprague-Dawley	en_US
dc.subject.mesh	Malus	en_US
dc.subject.mesh	Colitis, Ulcerative	en_US
dc.subject.mesh	Body Weight	en_US
dc.subject.mesh	Polymethacrylic Acids	en_US
dc.subject.mesh	Mesalamine	en_US
dc.subject.mesh	Peroxidase	en_US
dc.subject.mesh	Polysaccharides	en_US
dc.subject.mesh	Galactans	en_US
dc.subject.mesh	Mannans	en_US
dc.subject.mesh	Tablets	en_US
dc.subject.mesh	Probiotics	en_US
dc.subject.mesh	Plant Gums	en_US
dc.subject.mesh	Drug Liberation	en_US
dc.title	Efficacy of co-administration of modified apple polysaccharide and probiotics in guar gum-Eudragit S100 based mesalamine mini tablets: A novel approach in treating ulcerative colitis	en_US
dc.type	Journal Article
utslib.citation.volume	126	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	126	en_US

Abstract:

© 2018 Elsevier B.V. Modified Apple Polysaccharide (MAP) has been reported to cure colorectal diseases by up-regulating apoptosis and down regulating metastasis. In the present study, mesalamine (MES) and MAP mini tablets have been prepared and co-administered with probiotics to provide site specific release of drug. Probiotics along with MAP, which acts as a prebiotic would replenish the colonic microflora that have been compromised due to colorectal pathology. MES mini tablets were prepared keeping guar gum in the core and coating them with Eudragit S100 and guar gum. The optimized batch was explored for its curative potential on acetic acid induced ulcerative colitis (UC) in rat model with and without administration of probiotic and MAP. The results revealed that the rats treated with the combination of MAP and MES mini tablets along with probiotics show maximum curative potential. It was also observed that MAP mini tablets show better curative potential as compared to probiotics. The results of disease activity index, macroscopic scoring, antioxidant studies, tumour alpha and histopathological examination suggested that the rats treated with combination of MES-MAP mini tablets and probiotics have maximum therapeutic effect followed by MES mini tablets alone, MAP mini tablets alone and probiotics.

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http://hdl.handle.net/10453/136278