Emerging trends in the novel drug delivery approaches for the treatment of lung cancer

Sharma, P; Mehta, M; Dhanjal, DS; Kaur, S; Gupta, G; Singh, H; Thangavelu, L; Rajeshkumar, S; Tambuwala, M; Bakshi, HA; Chellappan, DK; Dua, K; Satija, S

Emerging trends in the novel drug delivery approaches for the treatment of lung cancer

Sharma, P Mehta, M Dhanjal, DS Kaur, S Gupta, G Singh, H Thangavelu, L Rajeshkumar, S Tambuwala, M Bakshi, HA Chellappan, DK Dua, K

Satija, S

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Publication Type:: Journal Article
Citation:: Chemico-Biological Interactions, 2019, 309
Issue Date:: 2019-08-25

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Field	Value	Language
dc.contributor.author	Sharma, P	en_US
dc.contributor.author	Mehta, M	en_US
dc.contributor.author	Dhanjal, DS	en_US
dc.contributor.author	Kaur, S	en_US
dc.contributor.author	Gupta, G	en_US
dc.contributor.author	Singh, H	en_US
dc.contributor.author	Thangavelu, L	en_US
dc.contributor.author	Rajeshkumar, S	en_US
dc.contributor.author	Tambuwala, M	en_US
dc.contributor.author	Bakshi, HA	en_US
dc.contributor.author	Chellappan, DK	en_US
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159	en_US
dc.contributor.author	Satija, S	en_US
dc.date.available	2019-06-17	en_US
dc.date.issued	2019-08-25	en_US
dc.identifier.citation	Chemico-Biological Interactions, 2019, 309	en_US
dc.identifier.issn	0009-2797	en_US
dc.identifier.uri	http://hdl.handle.net/10453/136279
dc.description.abstract	© 2019 Elsevier B.V. Cancer is one of the major diseases that cause a high number of deaths globally. Of the major types of cancers, lung cancer is known to be the most chronic form of cancer in the world. The conventional management of lung cancer includes different medical interventions like chemotherapy, surgical removal, and radiation therapy. However, this type of approach lacks specificity and also harms the adjacent normal cells. Lately, nanotechnology has emerged as a promising intervention in the management and treatment of lung cancers. Nanotechnology has revolutionized the existing modalities and focuses primarily on reducing toxicity and improving the bioavailability of anticancer drugs to the target tumor cells. Nanocarrier systems are being currently used extensively to exploit and to overcome the obstructions induced by cancers in the lungs. The nano-carrier-loaded therapeutic drug delivery methods have shown promising potential in treating lung cancer as its target is to control the growth of tumor cells. In this review, various modes of nano drug delivery options like liposomes, dendrimers, quantum dots, carbon nanotubes and metallic nanoparticles have been discussed. Nano-carrier drug delivery systems emerge as a promising approach and thus is expected to provide newer and advanced avenues in cancer therapeutics.	en_US
dc.relation.ispartof	Chemico-Biological Interactions	en_US
dc.relation.isbasedon	10.1016/j.cbi.2019.06.033	en_US
dc.subject.classification	Toxicology	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Lung Neoplasms	en_US
dc.subject.mesh	Antineoplastic Agents	en_US
dc.subject.mesh	Liposomes	en_US
dc.subject.mesh	Drug Carriers	en_US
dc.subject.mesh	Dendrimers	en_US
dc.subject.mesh	Nanoparticles	en_US
dc.title	Emerging trends in the novel drug delivery approaches for the treatment of lung cancer	en_US
dc.type	Journal Article
utslib.citation.volume	309	en_US
utslib.for	1112 Oncology and Carcinogenesis	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	309	en_US

Abstract:

© 2019 Elsevier B.V. Cancer is one of the major diseases that cause a high number of deaths globally. Of the major types of cancers, lung cancer is known to be the most chronic form of cancer in the world. The conventional management of lung cancer includes different medical interventions like chemotherapy, surgical removal, and radiation therapy. However, this type of approach lacks specificity and also harms the adjacent normal cells. Lately, nanotechnology has emerged as a promising intervention in the management and treatment of lung cancers. Nanotechnology has revolutionized the existing modalities and focuses primarily on reducing toxicity and improving the bioavailability of anticancer drugs to the target tumor cells. Nanocarrier systems are being currently used extensively to exploit and to overcome the obstructions induced by cancers in the lungs. The nano-carrier-loaded therapeutic drug delivery methods have shown promising potential in treating lung cancer as its target is to control the growth of tumor cells. In this review, various modes of nano drug delivery options like liposomes, dendrimers, quantum dots, carbon nanotubes and metallic nanoparticles have been discussed. Nano-carrier drug delivery systems emerge as a promising approach and thus is expected to provide newer and advanced avenues in cancer therapeutics.

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http://hdl.handle.net/10453/136279