Recent update on anti-dengue drug discovery

Publication Type:
Journal Article
European Journal of Medicinal Chemistry, 2019, 176 pp. 431 - 455
Issue Date:
Filename Description Size
1-s2.0-S0223523419304192-main.pdfPublished Version2.85 MB
Adobe PDF
Full metadata record
© 2019 Elsevier Masson SAS Dengue is the most important arthropod-borne viral disease of humans, with more than half of the global population living in at-risk areas. Despite the negative impact on public health, there are no antiviral therapies available, and the only licensed vaccine, Dengvaxia®, has been contraindicated in children below nine years of age. In an effort to combat dengue, several small molecules have entered into human clinical trials. Here, we review anti-DENV molecules and their drug targets that have been published within the past five years (2014–2018). Further, we discuss their probable mechanisms of action and describe a role for classes of clinically approved drugs and also an unclassified class of anti-DENV agents. This review aims to enhance our understanding of novel agents and their cognate targets in furthering innovations in the use of small molecules for dengue drug therapies.
Please use this identifier to cite or link to this item: