Reproductive outcomes following a stem cell transplant for a haematological malignancy in female cancer survivors: a systematic review and meta-analysis

Gerstl, B; Sullivan, E; Koch, J; Wand, H; Ives, A; Mitchell, R; Hamad, N; Anazodo, A

Reproductive outcomes following a stem cell transplant for a haematological malignancy in female cancer survivors: a systematic review and meta-analysis

Gerstl, B Sullivan, E

Koch, J Wand, H Ives, A Mitchell, R Hamad, N Anazodo, A

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Publication Type:: Journal Article
Citation:: Supportive Care in Cancer, 2019, 27 (12), pp. 4451 - 4460
Issue Date:: 2019-12-01

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Field	Value	Language
dc.contributor.author	Gerstl, B	en_US
dc.contributor.author	Sullivan, E https://orcid.org/0000-0002-8718-2753	en_US
dc.contributor.author	Koch, J	en_US
dc.contributor.author	Wand, H	en_US
dc.contributor.author	Ives, A	en_US
dc.contributor.author	Mitchell, R	en_US
dc.contributor.author	Hamad, N	en_US
dc.contributor.author	Anazodo, A	en_US
dc.date.available	2019-07-30	en_US
dc.date.issued	2019-12-01	en_US
dc.identifier.citation	Supportive Care in Cancer, 2019, 27 (12), pp. 4451 - 4460	en_US
dc.identifier.issn	0941-4355	en_US
dc.identifier.uri	http://hdl.handle.net/10453/136959
dc.description.abstract	© 2019, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: The use of high-dose chemotherapy and radiotherapy combined with haematopoietic stem cell transplantation (HSCT) may negatively affect a woman’s reproductive potential. Reproductive outcomes such as infertility are a major concern for women who undergo treatment for a haematological cancer diagnosis. Objective: This systematic review and meta-analysis explores reproductive outcomes following a haematological cancer requiring HSCT. Methods: Electronic databases were searched to identify studies that reported on reproductive outcomes after treatment for a haematological cancer diagnosis. Studies were included that reported on pregnancy and reproductive outcomes following HSCT for a haematological malignancy. Results: The meta-analysis included 14 studies, collectively involving 744 female patients. The subgroup analysis showed an overall pooled estimated pregnancy rate, for autologous or allogeneic HSCT recipients, of 22.7% (n = 438). There were 25% (n = 240) of women who became pregnant after autologous HSCT compared with 22% (n = 198) who subsequently became pregnant following allogeneic HSCT. Conclusions: This meta-analysis reflects low pregnancy rates for cancer survivors desiring a family. However, live births are improving over time with new technology and novel therapies. Hence, female cancer patients should be offered timely discussions, counselling and education around fertility preservation options prior to starting treatment with gonadotoxic therapy.	en_US
dc.relation.ispartof	Supportive Care in Cancer	en_US
dc.relation.isbasedon	10.1007/s00520-019-05020-8	en_US
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject.classification	Oncology & Carcinogenesis	en_US
dc.subject.mesh	Cancer Survivors	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Fertility Preservation	en_US
dc.subject.mesh	Hematologic Neoplasms	en_US
dc.subject.mesh	Hematopoietic Stem Cell Transplantation	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Pregnancy	en_US
dc.subject.mesh	Pregnancy Rate	en_US
dc.subject.mesh	Randomized Controlled Trials as Topic	en_US
dc.title	Reproductive outcomes following a stem cell transplant for a haematological malignancy in female cancer survivors: a systematic review and meta-analysis	en_US
dc.type	Journal Article
utslib.citation.volume	12	en_US
utslib.citation.volume	27	en_US
utslib.for	1112 Oncology and Carcinogenesis	en_US
utslib.for	1114 Paediatrics and Reproductive Medicine	en_US
utslib.for	11 Medical and Health Sciences	en_US
utslib.for	17 Psychology and Cognitive Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Public Health
utslib.copyright.status	closed_access	*
pubs.issue	12	en_US
pubs.publication-status	Published	en_US
pubs.volume	27	en_US

Abstract:

© 2019, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: The use of high-dose chemotherapy and radiotherapy combined with haematopoietic stem cell transplantation (HSCT) may negatively affect a woman’s reproductive potential. Reproductive outcomes such as infertility are a major concern for women who undergo treatment for a haematological cancer diagnosis. Objective: This systematic review and meta-analysis explores reproductive outcomes following a haematological cancer requiring HSCT. Methods: Electronic databases were searched to identify studies that reported on reproductive outcomes after treatment for a haematological cancer diagnosis. Studies were included that reported on pregnancy and reproductive outcomes following HSCT for a haematological malignancy. Results: The meta-analysis included 14 studies, collectively involving 744 female patients. The subgroup analysis showed an overall pooled estimated pregnancy rate, for autologous or allogeneic HSCT recipients, of 22.7% (n = 438). There were 25% (n = 240) of women who became pregnant after autologous HSCT compared with 22% (n = 198) who subsequently became pregnant following allogeneic HSCT. Conclusions: This meta-analysis reflects low pregnancy rates for cancer survivors desiring a family. However, live births are improving over time with new technology and novel therapies. Hence, female cancer patients should be offered timely discussions, counselling and education around fertility preservation options prior to starting treatment with gonadotoxic therapy.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/136959