Elemental bio-imaging of melanoma in lymph node biopsies

Hare, D; Burger, F; Austin, C; Fryer, F; Grimm, R; Reedy, B; Scolyer, R; Thompson, J; Doble, P

Elemental bio-imaging of melanoma in lymph node biopsies

Hare, D Burger, F Austin, C Fryer, F Grimm, R Reedy, B Scolyer, R Thompson, J Doble, P

Permalink

Publisher:: Royal Society of Chemistry
Publication Type:: Journal Article
Citation:: Hare Dominic et al. 2009, 'Elemental bio-imaging of melanoma in lymph node biopsies', Royal Society of Chemistry, vol. 134, no. 3, pp. 450-453.
Issue Date:: 2009

Closed Access

	Filename	Description	Size
	2009007087OK.pdf		437.71 kB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Hare, D	en_US
dc.contributor.author	Burger, F	en_US
dc.contributor.author	Austin, C	en_US
dc.contributor.author	Fryer, F	en_US
dc.contributor.author	Grimm, R	en_US
dc.contributor.author	Reedy, B	en_US
dc.contributor.author	Scolyer, R	en_US
dc.contributor.author	Thompson, J	en_US
dc.contributor.author	Doble, P	en_US
dc.date.accessioned	2011-02-07T06:24:13Z
dc.date.available	2011-02-07T06:24:13Z
dc.date.issued	2009	en_US
dc.identifier	2009007087	en_US
dc.identifier.citation	Hare Dominic et al. 2009, 'Elemental bio-imaging of melanoma in lymph node biopsies', Royal Society of Chemistry, vol. 134, no. 3, pp. 450-453.	en_US
dc.identifier.issn	0003-2654	en_US
dc.identifier.other	C1	en_US
dc.identifier.uri	http://hdl.handle.net/10453/13725
dc.description.abstract	The spatial distribution of trace elements in human lymph nodes partially infiltrated by melanoma cells was determined by elemental bio-imaging. Imaging op1p within the nodal capsule and normal lymph node tissue showed a clear demarcation of the tumour boundary, with a significant decrease in relative 31p concentration within the tumour. The location of the tumour boundary was confirmed by haematoxylin and eosin staining of serial sections and observation by light microscopy. Further enhancement of the tumour boundary was achieved by imaging the 3Jpj34S ratio. 31P/66Zn ratio images showed a decreasi,!lg ratio beyond the tumour boundary that extended into peritumour normal lymph node tissue.	en_US
dc.publisher	Royal Society of Chemistry	en_US
dc.relation.ispartof	The Analyst	en_US
dc.relation.ispartof	Verified OK	en_US
dc.relation.isbasedon	http://dx.doi.org/10.1039/b812745j	en_US
dc.subject.classification	Radiology and Organ Imaging	en_US
dc.title	Elemental bio-imaging of melanoma in lymph node biopsies	en_US
dc.type	Journal article
utslib.citation.volume	134	en_US
utslib.citation.number	3	en_US
utslib.location	Cambridge, UK	en_US
utslib.citation.startpage	450	en_US
utslib.citation.endpage	453	en_US
utslib.identifier.org	SCI.Chemistry and Forensic Sciences	en_US
utslib.for	110320	en_US
utslib.percentage	000100	en_US
utslib.copyright.status	closed_access

Abstract:

The spatial distribution of trace elements in human lymph nodes partially infiltrated by melanoma cells was determined by elemental bio-imaging. Imaging op1p within the nodal capsule and normal lymph node tissue showed a clear demarcation of the tumour boundary, with a significant decrease in relative 31p concentration within the tumour. The location of the tumour boundary was confirmed by haematoxylin and eosin staining of serial sections and observation by light microscopy. Further enhancement of the tumour boundary was achieved by imaging the 3Jpj34S ratio. 31P/66Zn ratio images showed a decreasi,!lg ratio beyond the tumour boundary that extended into peritumour normal lymph node tissue.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/13725