Elemental bio-imaging of melanoma in lymph node biopsies

Royal Society of Chemistry
Publication Type:
Journal Article
Hare Dominic et al. 2009, 'Elemental bio-imaging of melanoma in lymph node biopsies', Royal Society of Chemistry, vol. 134, no. 3, pp. 450-453.
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The spatial distribution of trace elements in human lymph nodes partially infiltrated by melanoma cells was determined by elemental bio-imaging. Imaging op1p within the nodal capsule and normal lymph node tissue showed a clear demarcation of the tumour boundary, with a significant decrease in relative 31p concentration within the tumour. The location of the tumour boundary was confirmed by haematoxylin and eosin staining of serial sections and observation by light microscopy. Further enhancement of the tumour boundary was achieved by imaging the 3Jpj34S ratio. 31P/66Zn ratio images showed a decreasi,!lg ratio beyond the tumour boundary that extended into peritumour normal lymph node tissue.
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