In utero exposure to breast cancer treatment: a population-based perinatal outcome study

Safi, N; Anazodo, A; Dickinson, JE; Lui, K; Wang, AY; Li, Z; Sullivan, EA

In utero exposure to breast cancer treatment: a population-based perinatal outcome study

Safi, N

Anazodo, A Dickinson, JE Lui, K Wang, AY Li, Z

Sullivan, EA

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Publication Type:: Journal Article
Citation:: British Journal of Cancer, 2019, 121 (8), pp. 719 - 721
Issue Date:: 2019-10-15

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Field	Value	Language
dc.contributor.author	Safi, N https://orcid.org/0000-0001-8473-0980	en_US
dc.contributor.author	Anazodo, A	en_US
dc.contributor.author	Dickinson, JE	en_US
dc.contributor.author	Lui, K	en_US
dc.contributor.author	Wang, AY	en_US
dc.contributor.author	Li, Z https://orcid.org/0000-0002-7622-150X	en_US
dc.contributor.author	Sullivan, EA https://orcid.org/0000-0002-8718-2753	en_US
dc.date.available	2020-05-25T19:02:54Z
dc.date.issued	2019-10-15	en_US
dc.identifier.citation	British Journal of Cancer, 2019, 121 (8), pp. 719 - 721	en_US
dc.identifier.issn	0007-0920	en_US
dc.identifier.uri	http://hdl.handle.net/10453/139141
dc.description.abstract	© 2019, Cancer Research UK. Chemotherapy during a viable pregnancy may be associated with adverse perinatal outcomes. We conducted a prospective cohort study to examine the perinatal outcomes of babies born following in utero exposure to chemotherapy in Australia and New Zealand. Over 18 months we identified 24 births, of >400 g and/or >20-weeks’ gestation, to women diagnosed with breast cancer in the first or second trimesters. Eighteen babies were exposed in utero to chemotherapy. Chemotherapy commenced at a median of 20 weeks gestation, for a mean duration of 10 weeks. Twelve exposed infants were born preterm with 11 by induced labour or pre-labour caesarean section. There were no perinatal deaths or congenital malformations. Our findings show that breast cancer diagnosed during mid-pregnancy is often treated with chemotherapy. Other than induced preterm births, there were no serious adverse perinatal outcomes.	en_US
dc.relation.ispartof	British Journal of Cancer	en_US
dc.relation.isbasedon	10.1038/s41416-019-0563-x	en_US
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.classification	Oncology & Carcinogenesis	en_US
dc.title	In utero exposure to breast cancer treatment: a population-based perinatal outcome study	en_US
dc.type	Journal Article
utslib.citation.volume	8	en_US
utslib.citation.volume	121	en_US
utslib.for	1112 Oncology and Carcinogenesis	en_US
utslib.for	1117 Public Health and Health Services	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/IMPACCT
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Public Health
utslib.copyright.status	open_access	*
pubs.issue	8	en_US
pubs.publication-status	Published	en_US
pubs.volume	121	en_US

Abstract:

© 2019, Cancer Research UK. Chemotherapy during a viable pregnancy may be associated with adverse perinatal outcomes. We conducted a prospective cohort study to examine the perinatal outcomes of babies born following in utero exposure to chemotherapy in Australia and New Zealand. Over 18 months we identified 24 births, of >400 g and/or >20-weeks’ gestation, to women diagnosed with breast cancer in the first or second trimesters. Eighteen babies were exposed in utero to chemotherapy. Chemotherapy commenced at a median of 20 weeks gestation, for a mean duration of 10 weeks. Twelve exposed infants were born preterm with 11 by induced labour or pre-labour caesarean section. There were no perinatal deaths or congenital malformations. Our findings show that breast cancer diagnosed during mid-pregnancy is often treated with chemotherapy. Other than induced preterm births, there were no serious adverse perinatal outcomes.

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http://hdl.handle.net/10453/139141