A survey of infectious diseases and vaccination uptake in long-term hematopoietic stem cell transplant survivors in Australia.

Dyer, G; Gilroy, N; Brice, L; Kabir, M; Gottlieb, D; Huang, G; Hogg, M; Brown, L; Greenwood, M; Larsen, SR; Moore, J; Hertzberg, M; Tan, J; Ward, C; Kerridge, I

A survey of infectious diseases and vaccination uptake in long-term hematopoietic stem cell transplant survivors in Australia.

Dyer, G Gilroy, N Brice, L Kabir, M Gottlieb, D Huang, G Hogg, M Brown, L Greenwood, M Larsen, SR Moore, J Hertzberg, M Tan, J Ward, C Kerridge, I

Permalink

Publisher:: WILEY
Publication Type:: Journal Article
Citation:: Transplant infectious disease : an official journal of the Transplantation Society, 2019, 21, (2), pp. e13043
Issue Date:: 2019-04

Closed Access

	Filename	Description	Size
	ContentServer (4).pdf	Published version	561.71 kB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Dyer, G
dc.contributor.author	Gilroy, N
dc.contributor.author	Brice, L
dc.contributor.author	Kabir, M
dc.contributor.author	Gottlieb, D
dc.contributor.author	Huang, G
dc.contributor.author	Hogg, M
dc.contributor.author	Brown, L
dc.contributor.author	Greenwood, M
dc.contributor.author	Larsen, SR
dc.contributor.author	Moore, J
dc.contributor.author	Hertzberg, M
dc.contributor.author	Tan, J
dc.contributor.author	Ward, C
dc.contributor.author	Kerridge, I
dc.date.accessioned	2020-05-28T08:20:23Z
dc.date.available	2018-12-09
dc.date.available	2020-05-28T08:20:23Z
dc.date.issued	2019-04
dc.identifier.citation	Transplant infectious disease : an official journal of the Transplantation Society, 2019, 21, (2), pp. e13043
dc.identifier.issn	1398-2273
dc.identifier.issn	1399-3062
dc.identifier.uri	http://hdl.handle.net/10453/140982
dc.description.abstract	BACKGROUND:This cross-sectional survey aimed to establish the prevalence of infectious diseases and vaccination uptake in long-term allogeneic hematopoietic stem cell transplants (HSCT) survivors in New South Wales, in order to reduce long-term post-HSCT morbidity and mortality and enhance long-term care. PATIENTS AND METHODS:Hematopoietic stem cell transplants survivors aged over 18 years and transplanted between 2000-2012 in New South Wales (NSW) were eligible to participate. Survivors self-completed the Sydney Post BMT Study survey, FACT-BMT (V4), Chronic Graft versus Host Disease (cGVHD) Activity Assessment Self Report, Lee Chronic GvHD Symptom Scale, DASS21, Post Traumatic Growth Inventory, and the Fear of Recurrence Scale. RESULTS:Of the 583 HSCT survivors contacted, 441 (78%) completed the survey. Respondents included 250 (57%) males and median age was 54 years (range 19-79 years). The median age at the time of transplant was 49 years (Range: 17-71), the median time since HSCT was 5 years (Range: 1-14) and 69% had cGVHD. Collectively, 41.7% of survivors reported a vaccine preventable disease (VPD) with the most common being influenza-like-illness (38.4%), varicella zoster/shingles (27.9%), pap smear abnormalities (9.8%), pneumococcal disease (5.1%), and varicella zoster (chicken pox) (4.6%). Only 31.8% had received the full post-HSCT vaccination schedule, and the majority (69.8%) of these had received the vaccines via their General Practitioner. cGVHD was not found to be a significant factor on multivariate analysis for those who were vaccinated. There was a trend toward lower vaccination rates in patients in a lower income strata. CONCLUSIONS:Vaccinating post-HSCT survivors to prevent infections and their consequences have an established role in post-HSCT care. Improving rates of post-HSCT vaccination should be a major priority for BMT units.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	WILEY
dc.relation.ispartof	Transplant infectious disease : an official journal of the Transplantation Society
dc.relation.isbasedon	10.1111/tid.13043
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	1103 Clinical Sciences
dc.subject.classification	Surgery
dc.subject.mesh	Humans
dc.subject.mesh	Communicable Diseases
dc.subject.mesh	Vaccination
dc.subject.mesh	Hematopoietic Stem Cell Transplantation
dc.subject.mesh	Transplantation, Homologous
dc.subject.mesh	Prevalence
dc.subject.mesh	Cross-Sectional Studies
dc.subject.mesh	Adolescent
dc.subject.mesh	Adult
dc.subject.mesh	Aged
dc.subject.mesh	Middle Aged
dc.subject.mesh	Survivors
dc.subject.mesh	Australia
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.subject.mesh	Young Adult
dc.subject.mesh	Surveys and Questionnaires
dc.subject.mesh	Adolescent
dc.subject.mesh	Adult
dc.subject.mesh	Aged
dc.subject.mesh	Australia
dc.subject.mesh	Communicable Diseases
dc.subject.mesh	Cross-Sectional Studies
dc.subject.mesh	Female
dc.subject.mesh	Hematopoietic Stem Cell Transplantation
dc.subject.mesh	Humans
dc.subject.mesh	Male
dc.subject.mesh	Middle Aged
dc.subject.mesh	Prevalence
dc.subject.mesh	Surveys and Questionnaires
dc.subject.mesh	Survivors
dc.subject.mesh	Transplantation, Homologous
dc.subject.mesh	Vaccination
dc.subject.mesh	Young Adult
dc.title	A survey of infectious diseases and vaccination uptake in long-term hematopoietic stem cell transplant survivors in Australia.
dc.type	Journal Article
utslib.citation.volume	21
utslib.location.activity	Denmark
utslib.for	1103 Clinical Sciences
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	closed_access	*
dc.date.updated	2020-05-28T08:20:20Z
pubs.issue	2
pubs.publication-status	Published
pubs.volume	21
utslib.start-page	e13043
utslib.citation.issue	2

Abstract:

BACKGROUND:This cross-sectional survey aimed to establish the prevalence of infectious diseases and vaccination uptake in long-term allogeneic hematopoietic stem cell transplants (HSCT) survivors in New South Wales, in order to reduce long-term post-HSCT morbidity and mortality and enhance long-term care. PATIENTS AND METHODS:Hematopoietic stem cell transplants survivors aged over 18 years and transplanted between 2000-2012 in New South Wales (NSW) were eligible to participate. Survivors self-completed the Sydney Post BMT Study survey, FACT-BMT (V4), Chronic Graft versus Host Disease (cGVHD) Activity Assessment Self Report, Lee Chronic GvHD Symptom Scale, DASS21, Post Traumatic Growth Inventory, and the Fear of Recurrence Scale. RESULTS:Of the 583 HSCT survivors contacted, 441 (78%) completed the survey. Respondents included 250 (57%) males and median age was 54 years (range 19-79 years). The median age at the time of transplant was 49 years (Range: 17-71), the median time since HSCT was 5 years (Range: 1-14) and 69% had cGVHD. Collectively, 41.7% of survivors reported a vaccine preventable disease (VPD) with the most common being influenza-like-illness (38.4%), varicella zoster/shingles (27.9%), pap smear abnormalities (9.8%), pneumococcal disease (5.1%), and varicella zoster (chicken pox) (4.6%). Only 31.8% had received the full post-HSCT vaccination schedule, and the majority (69.8%) of these had received the vaccines via their General Practitioner. cGVHD was not found to be a significant factor on multivariate analysis for those who were vaccinated. There was a trend toward lower vaccination rates in patients in a lower income strata. CONCLUSIONS:Vaccinating post-HSCT survivors to prevent infections and their consequences have an established role in post-HSCT care. Improving rates of post-HSCT vaccination should be a major priority for BMT units.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/140982