Emerging era of "somes": polymersomes as versatile drug delivery carrier for cancer diagnostics and therapy.

Sharma, AK; Prasher, P; Aljabali, AA; Mishra, V; Gandhi, H; Kumar, S; Mutalik, S; Chellappan, DK; Tambuwala, MM; Dua, K; Kapoor, DN

Emerging era of "somes": polymersomes as versatile drug delivery carrier for cancer diagnostics and therapy.

Sharma, AK Prasher, P Aljabali, AA Mishra, V Gandhi, H Kumar, S Mutalik, S Chellappan, DK Tambuwala, MM Dua, K

Kapoor, DN

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Publisher:: Springer Science and Business Media LLC
Publication Type:: Journal Article
Citation:: Drug delivery and translational research, 2020
Issue Date:: 2020-06-05

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Field	Value	Language
dc.contributor.author	Sharma, AK
dc.contributor.author	Prasher, P
dc.contributor.author	Aljabali, AA
dc.contributor.author	Mishra, V
dc.contributor.author	Gandhi, H
dc.contributor.author	Kumar, S
dc.contributor.author	Mutalik, S
dc.contributor.author	Chellappan, DK
dc.contributor.author	Tambuwala, MM
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Kapoor, DN
dc.date.accessioned	2020-06-19T00:51:09Z
dc.date.available	2021-08-12T19:00:54Z
dc.date.issued	2020-06-05
dc.identifier.citation	Drug delivery and translational research, 2020
dc.identifier.issn	2190-393X
dc.identifier.issn	2190-3948
dc.identifier.uri	http://hdl.handle.net/10453/141553
dc.description.abstract	Over the past two decades, polymersomes have been widely investigated for the delivery of diagnostic and therapeutic agents in cancer therapy. Polymersomes are stable polymeric vesicles, which are prepared using amphiphilic block polymers of different molecular weights. The use of high molecular weight amphiphilic copolymers allows for possible manipulation of membrane characteristics, which in turn enhances the efficiency of drug delivery. Polymersomes are more stable in comparison with liposomes and show less toxicity in vivo. Furthermore, their ability to encapsulate both hydrophilic and hydrophobic drugs, significant biocompatibility, robustness, high colloidal stability, and simple methods for ligands conjugation make polymersomes a promising candidate for therapeutic drug delivery in cancer therapy. This review is focused on current development in the application of polymersomes for cancer therapy and diagnosis. Graphical abstract.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Springer Science and Business Media LLC
dc.relation.ispartof	Drug delivery and translational research
dc.relation.isbasedon	10.1007/s13346-020-00789-2
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.subject	1115 Pharmacology and Pharmaceutical Sciences
dc.title	Emerging era of "somes": polymersomes as versatile drug delivery carrier for cancer diagnostics and therapy.
dc.type	Journal Article
utslib.location.activity	United States
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	open_access	*
dc.date.updated	2020-06-19T00:51:04Z
pubs.publication-status	Published

Abstract:

Over the past two decades, polymersomes have been widely investigated for the delivery of diagnostic and therapeutic agents in cancer therapy. Polymersomes are stable polymeric vesicles, which are prepared using amphiphilic block polymers of different molecular weights. The use of high molecular weight amphiphilic copolymers allows for possible manipulation of membrane characteristics, which in turn enhances the efficiency of drug delivery. Polymersomes are more stable in comparison with liposomes and show less toxicity in vivo. Furthermore, their ability to encapsulate both hydrophilic and hydrophobic drugs, significant biocompatibility, robustness, high colloidal stability, and simple methods for ligands conjugation make polymersomes a promising candidate for therapeutic drug delivery in cancer therapy. This review is focused on current development in the application of polymersomes for cancer therapy and diagnosis. Graphical abstract.

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http://hdl.handle.net/10453/141553