Anti-bacterial activity of inorganic nanomaterials and their antimicrobial peptide conjugates against resistant and non-resistant pathogens.

Pardhi, DM; Şen Karaman, D; Timonen, J; Wu, W; Zhang, Q; Satija, S; Mehta, M; Charbe, N; McCarron, PA; Tambuwala, MM; Bakshi, HA; Negi, P; Aljabali, AA; Dua, K; Chellappan, DK; Behera, A; Pathak, K; Watharkar, RB; Rautio, J; Rosenholm, JM

Anti-bacterial activity of inorganic nanomaterials and their antimicrobial peptide conjugates against resistant and non-resistant pathogens.

Pardhi, DM Şen Karaman, D Timonen, J Wu, W Zhang, Q Satija, S

Mehta, M Charbe, N McCarron, PA Tambuwala, MM Bakshi, HA Negi, P Aljabali, AA Dua, K

Chellappan, DK Behera, A Pathak, K Watharkar, RB Rautio, J Rosenholm, JM

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Publisher:: Elsevier BV
Publication Type:: Journal Article
Citation:: International journal of pharmaceutics, 2020, 586
Issue Date:: 2020-06-12

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Field	Value	Language
dc.contributor.author	Pardhi, DM
dc.contributor.author	Şen Karaman, D
dc.contributor.author	Timonen, J
dc.contributor.author	Wu, W
dc.contributor.author	Zhang, Q
dc.contributor.author	Satija, S https://orcid.org/0000-0003-4702-6534
dc.contributor.author	Mehta, M
dc.contributor.author	Charbe, N
dc.contributor.author	McCarron, PA
dc.contributor.author	Tambuwala, MM
dc.contributor.author	Bakshi, HA
dc.contributor.author	Negi, P
dc.contributor.author	Aljabali, AA
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Chellappan, DK
dc.contributor.author	Behera, A
dc.contributor.author	Pathak, K
dc.contributor.author	Watharkar, RB
dc.contributor.author	Rautio, J
dc.contributor.author	Rosenholm, JM
dc.date.accessioned	2020-07-29T03:24:43Z
dc.date.available	2020-06-06
dc.date.available	2020-07-29T03:24:43Z
dc.date.issued	2020-06-12
dc.identifier.citation	International journal of pharmaceutics, 2020, 586
dc.identifier.issn	0378-5173
dc.identifier.issn	1873-3476
dc.identifier.uri	http://hdl.handle.net/10453/141908
dc.description.abstract	This review details the antimicrobial applications of inorganic nanomaterials of mostly metallic form, and the augmentation of activity by surface conjugation of peptide ligands. The review is subdivided into three main sections, of which the first describes the antimicrobial activity of inorganic nanomaterials against gram-positive, gram-negative and multidrug-resistant bacterial strains. The second section highlights the range of antimicrobial peptides and the drug resistance strategies employed by bacterial species to counter lethality. The final part discusses the role of antimicrobial peptide-decorated inorganic nanomaterials in the fight against bacterial strains that show resistance. General strategies for the preparation of antimicrobial peptides and their conjugation to nanomaterials are discussed, emphasizing the use of elemental and metallic oxide nanomaterials. Importantly, the permeation of antimicrobial peptides through the bacterial membrane is shown to aid the delivery of nanomaterials into bacterial cells. By judicious use of targeting ligands, the nanomaterial becomes able to differentiate between bacterial and mammalian cells and, thus, reduce side effects. Moreover, peptide conjugation to the surface of a nanomaterial will alter surface chemistry in ways that lead to reduction in toxicity and improvements in biocompatibility.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier BV
dc.relation.ispartof	International journal of pharmaceutics
dc.relation.isbasedon	10.1016/j.ijpharm.2020.119531
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Pharmacology & Pharmacy
dc.title	Anti-bacterial activity of inorganic nanomaterials and their antimicrobial peptide conjugates against resistant and non-resistant pathogens.
dc.type	Journal Article
utslib.citation.volume	586
utslib.location.activity	Netherlands
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2020-07-29T03:24:33Z
pubs.publication-status	Published
pubs.volume	586

Abstract:

This review details the antimicrobial applications of inorganic nanomaterials of mostly metallic form, and the augmentation of activity by surface conjugation of peptide ligands. The review is subdivided into three main sections, of which the first describes the antimicrobial activity of inorganic nanomaterials against gram-positive, gram-negative and multidrug-resistant bacterial strains. The second section highlights the range of antimicrobial peptides and the drug resistance strategies employed by bacterial species to counter lethality. The final part discusses the role of antimicrobial peptide-decorated inorganic nanomaterials in the fight against bacterial strains that show resistance. General strategies for the preparation of antimicrobial peptides and their conjugation to nanomaterials are discussed, emphasizing the use of elemental and metallic oxide nanomaterials. Importantly, the permeation of antimicrobial peptides through the bacterial membrane is shown to aid the delivery of nanomaterials into bacterial cells. By judicious use of targeting ligands, the nanomaterial becomes able to differentiate between bacterial and mammalian cells and, thus, reduce side effects. Moreover, peptide conjugation to the surface of a nanomaterial will alter surface chemistry in ways that lead to reduction in toxicity and improvements in biocompatibility.

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http://hdl.handle.net/10453/141908