Emerging therapeutic potential of the iridoid molecule, asperuloside: A snapshot of its underlying molecular mechanisms.

Chan, Y; Ng, SW; Xin Tan, JZ; Gupta, G; Tambuwala, MM; Bakshi, HA; Dureja, H; Dua, K; Ishaq, M; Caruso, V; Chellappan, DK

Emerging therapeutic potential of the iridoid molecule, asperuloside: A snapshot of its underlying molecular mechanisms.

Chan, Y Ng, SW Xin Tan, JZ Gupta, G Tambuwala, MM Bakshi, HA Dureja, H Dua, K

Ishaq, M Caruso, V Chellappan, DK

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Publisher:: ELSEVIER IRELAND LTD
Publication Type:: Journal Article
Citation:: Chemico-biological interactions, 2020, 315
Issue Date:: 2020-01

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Field	Value	Language
dc.contributor.author	Chan, Y
dc.contributor.author	Ng, SW
dc.contributor.author	Xin Tan, JZ
dc.contributor.author	Gupta, G
dc.contributor.author	Tambuwala, MM
dc.contributor.author	Bakshi, HA
dc.contributor.author	Dureja, H
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Ishaq, M
dc.contributor.author	Caruso, V
dc.contributor.author	Chellappan, DK
dc.date.accessioned	2020-08-17T02:48:12Z
dc.date.available	2019-11-27
dc.date.available	2020-08-17T02:48:12Z
dc.date.issued	2020-01
dc.identifier.citation	Chemico-biological interactions, 2020, 315
dc.identifier.issn	0009-2797
dc.identifier.issn	1872-7786
dc.identifier.uri	http://hdl.handle.net/10453/142141
dc.description.abstract	Over the years, the attention of researchers in the field of modern drug discovery and development has become further intense on the identification of active compounds from plant sources and traditional remedies, as they exhibit higher therapeutic efficacies and improved toxicological profiles. Among the large diversity of plant extracts that have been discovered and explored for their potential therapeutic benefits, asperuloside, an iridoid glycoside, has been proven to provide promising effects as a therapeutic agent for several diseases. Although, this potent substance exists in several genera, it is primarily found in plants belonging to the genus Eucommia. Recent decades have seen a surge in the research on Asperuloside, making it one of the most studied natural products in the field of medicine and pharmacology. In this review, we have attempted to study the various reported mechanisms of asperuloside that form the basis of its wide spectrum of pharmacological activities.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	ELSEVIER IRELAND LTD
dc.relation.ispartof	Chemico-biological interactions
dc.relation.isbasedon	10.1016/j.cbi.2019.108911
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0601 Biochemistry and Cell Biology
dc.subject.classification	Toxicology
dc.subject.mesh	Animals
dc.subject.mesh	Humans
dc.subject.mesh	Eucommiaceae
dc.subject.mesh	Iridoids
dc.subject.mesh	Pyrans
dc.subject.mesh	Glucosides
dc.subject.mesh	Plant Extracts
dc.subject.mesh	Cyclopentane Monoterpenes
dc.subject.mesh	Animals
dc.subject.mesh	Humans
dc.subject.mesh	Eucommiaceae
dc.subject.mesh	Iridoids
dc.subject.mesh	Pyrans
dc.subject.mesh	Glucosides
dc.subject.mesh	Plant Extracts
dc.subject.mesh	Cyclopentane Monoterpenes
dc.subject.mesh	Animals
dc.subject.mesh	Cyclopentane Monoterpenes
dc.subject.mesh	Eucommiaceae
dc.subject.mesh	Glucosides
dc.subject.mesh	Humans
dc.subject.mesh	Iridoids
dc.subject.mesh	Plant Extracts
dc.subject.mesh	Pyrans
dc.title	Emerging therapeutic potential of the iridoid molecule, asperuloside: A snapshot of its underlying molecular mechanisms.
dc.type	Journal Article
utslib.citation.volume	315
utslib.location.activity	Ireland
utslib.for	0601 Biochemistry and Cell Biology
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2020-08-17T02:48:00Z
pubs.publication-status	Published
pubs.volume	315

Abstract:

Over the years, the attention of researchers in the field of modern drug discovery and development has become further intense on the identification of active compounds from plant sources and traditional remedies, as they exhibit higher therapeutic efficacies and improved toxicological profiles. Among the large diversity of plant extracts that have been discovered and explored for their potential therapeutic benefits, asperuloside, an iridoid glycoside, has been proven to provide promising effects as a therapeutic agent for several diseases. Although, this potent substance exists in several genera, it is primarily found in plants belonging to the genus Eucommia. Recent decades have seen a surge in the research on Asperuloside, making it one of the most studied natural products in the field of medicine and pharmacology. In this review, we have attempted to study the various reported mechanisms of asperuloside that form the basis of its wide spectrum of pharmacological activities.

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http://hdl.handle.net/10453/142141