Development of modified apple polysaccharide capped silver nanoparticles loaded with mesalamine for effective treatment of ulcerative colitis

Kaur, G; Singh, SK; Kumar, R; Kumar, B; Kumari, Y; Gulati, M; Pandey, NK; Gowthamarajan, K; Ghosh, D; Clarisse, A; Wadhwa, S; Mehta, M; Satija, S; Dua, K; Dureja, H; Gupta, S; Singh, PK; Kapoor, B; Chitranshi, N; Kumar, A; Porwal, O

Development of modified apple polysaccharide capped silver nanoparticles loaded with mesalamine for effective treatment of ulcerative colitis

Kaur, G Singh, SK Kumar, R Kumar, B Kumari, Y Gulati, M Pandey, NK Gowthamarajan, K Ghosh, D Clarisse, A Wadhwa, S Mehta, M Satija, S

Dua, K

Dureja, H Gupta, S Singh, PK Kapoor, B Chitranshi, N Kumar, A Porwal, O

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Publisher:: Elsevier BV
Publication Type:: Journal Article
Citation:: Journal of Drug Delivery Science and Technology, 2020, 60
Issue Date:: 2020-12-01

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Field	Value	Language
dc.contributor.author	Kaur, G
dc.contributor.author	Singh, SK
dc.contributor.author	Kumar, R
dc.contributor.author	Kumar, B
dc.contributor.author	Kumari, Y
dc.contributor.author	Gulati, M
dc.contributor.author	Pandey, NK
dc.contributor.author	Gowthamarajan, K
dc.contributor.author	Ghosh, D
dc.contributor.author	Clarisse, A
dc.contributor.author	Wadhwa, S
dc.contributor.author	Mehta, M
dc.contributor.author	Satija, S https://orcid.org/0000-0003-4702-6534
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Dureja, H
dc.contributor.author	Gupta, S
dc.contributor.author	Singh, PK
dc.contributor.author	Kapoor, B
dc.contributor.author	Chitranshi, N
dc.contributor.author	Kumar, A
dc.contributor.author	Porwal, O
dc.date.accessioned	2020-09-03T06:50:02Z
dc.date.available	2020-09-03T06:50:02Z
dc.date.issued	2020-12-01
dc.identifier.citation	Journal of Drug Delivery Science and Technology, 2020, 60
dc.identifier.issn	1157-1489
dc.identifier.issn	1773-2247
dc.identifier.uri	http://hdl.handle.net/10453/142534
dc.description.abstract	© 2020 Elsevier B.V. The objective of study was to develop modified apple polysaccharide (MAP) based silver nanoparticles (AgNPs) loaded with mesalamine (MES) for effective treatment of ulcerative colitis in acetic acid induced rat model. AgNPs were prepared by reducing silver nitrate using MAP solution. The size and zeta potential of AgNPs was 89 ± 3 nm and −16.3 ± 1.54 mV and AgNPs loaded with MES (AgNPs-MES) was 101 ± 9 nm and −14.27 ± 2.16 mV. The dissolution study revealed about 54% drug release after 5 h indicating release of drug at the colonic site. The in vivo study was carried out on acetic acid induced ulcerative colitis rats and efficacy of treatment was assessed through evaluation of disease activity index and level of antioxidants as well as tumor necrosis factor-α after 7th and 14th day of induction of colitis. Histopathological evaluation of colonic tissue was also carried out. The results revealed that AgNPs-MES (high dose) provided better therapeutic efficacy for the treatment of UC as compared to its low dose, MES alone, MES-MAP, AgNPs alone and MAP alone. It was concluded that MAP based AgNPs loaded with MES were successfully formulated and found to be effective in treating ulcerative colitis.
dc.language	en
dc.publisher	Elsevier BV
dc.relation.ispartof	Journal of Drug Delivery Science and Technology
dc.relation.isbasedon	10.1016/j.jddst.2020.101980
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Pharmacology & Pharmacy
dc.title	Development of modified apple polysaccharide capped silver nanoparticles loaded with mesalamine for effective treatment of ulcerative colitis
dc.type	Journal Article
utslib.citation.volume	60
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2020-09-03T06:49:48Z
pubs.publication-status	Accepted
pubs.volume	60

Abstract:

© 2020 Elsevier B.V. The objective of study was to develop modified apple polysaccharide (MAP) based silver nanoparticles (AgNPs) loaded with mesalamine (MES) for effective treatment of ulcerative colitis in acetic acid induced rat model. AgNPs were prepared by reducing silver nitrate using MAP solution. The size and zeta potential of AgNPs was 89 ± 3 nm and −16.3 ± 1.54 mV and AgNPs loaded with MES (AgNPs-MES) was 101 ± 9 nm and −14.27 ± 2.16 mV. The dissolution study revealed about 54% drug release after 5 h indicating release of drug at the colonic site. The in vivo study was carried out on acetic acid induced ulcerative colitis rats and efficacy of treatment was assessed through evaluation of disease activity index and level of antioxidants as well as tumor necrosis factor-α after 7th and 14th day of induction of colitis. Histopathological evaluation of colonic tissue was also carried out. The results revealed that AgNPs-MES (high dose) provided better therapeutic efficacy for the treatment of UC as compared to its low dose, MES alone, MES-MAP, AgNPs alone and MAP alone. It was concluded that MAP based AgNPs loaded with MES were successfully formulated and found to be effective in treating ulcerative colitis.

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http://hdl.handle.net/10453/142534