MicroRNAs as Biomarker for Breast Cancer.

Aggarwal, T; Wadhwa, R; Gupta, R; Paudel, KR; Collet, T; Chellapan, DK; Gupta, G; Perumalsamy, H; Mehta, M; Satija, S; Hansbro, PM; Dua, K; Maurya, PK

MicroRNAs as Biomarker for Breast Cancer.

Aggarwal, T Wadhwa, R Gupta, R Paudel, KR Collet, T Chellapan, DK Gupta, G Perumalsamy, H Mehta, M Satija, S

Hansbro, PM Dua, K

Maurya, PK

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Publisher:: Bentham Science Publishers Ltd.
Publication Type:: Journal Article
Citation:: Endocrine, metabolic & immune disorders drug targets, 2020, 20
Issue Date:: 2020-04-28

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Field	Value	Language
dc.contributor.author	Aggarwal, T
dc.contributor.author	Wadhwa, R
dc.contributor.author	Gupta, R
dc.contributor.author	Paudel, KR
dc.contributor.author	Collet, T
dc.contributor.author	Chellapan, DK
dc.contributor.author	Gupta, G
dc.contributor.author	Perumalsamy, H
dc.contributor.author	Mehta, M
dc.contributor.author	Satija, S https://orcid.org/0000-0003-4702-6534
dc.contributor.author	Hansbro, PM
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Maurya, PK
dc.date.accessioned	2020-09-10T03:19:27Z
dc.date.available	2020-01-24
dc.date.available	2020-09-10T03:19:27Z
dc.date.issued	2020-04-28
dc.identifier.citation	Endocrine, metabolic & immune disorders drug targets, 2020, 20
dc.identifier.issn	1871-5303
dc.identifier.issn	2212-3873
dc.identifier.uri	http://hdl.handle.net/10453/142608
dc.description.abstract	Regardless of advances in detection and treatment, breast cancer is a major cause of women death and affecting about 1.5 million women all over the world. Since the last decade, genome wide association studies (GWAS) have been extensively conducted for breast cancer to define the role of miRNA as a tool for diagnosis, prognosis and therapeutics. MicroRNAs are small, non-coding RNAs that are associated with regulation of key cellular processes such as cell multiplication, differentiation, and death. They cause disturbance in the cell physiology by interfering directly with the translation and stability of a targeted gene transcript. MicroRNAs (miRNAs) constitute large family of non-coding RNAs which regulate target gene expression and protein levels that affect several human diseases and are suggested as the novel markers or therapeutic targets, including breast cancer. MicroRNA (miRNA) alterations are not only associated with metastasis, tumor genesis but also used as biomarkers for breast cancer diagnosis or prognosis. These are explained in detail in the following review. This review will also provide an impetus for more studies on the role of microRNAs in breast cancer.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Bentham Science Publishers Ltd.
dc.relation.ispartof	Endocrine, metabolic & immune disorders drug targets
dc.relation.isbasedon	10.2174/1871530320666200428113051
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1107 Immunology, 1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Immunology
dc.title	MicroRNAs as Biomarker for Breast Cancer.
dc.type	Journal Article
utslib.citation.volume	20
utslib.location.activity	United Arab Emirates
utslib.for	1107 Immunology
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2020-09-10T03:19:17Z
pubs.publication-status	Published
pubs.volume	20

Abstract:

Regardless of advances in detection and treatment, breast cancer is a major cause of women death and affecting about 1.5 million women all over the world. Since the last decade, genome wide association studies (GWAS) have been extensively conducted for breast cancer to define the role of miRNA as a tool for diagnosis, prognosis and therapeutics. MicroRNAs are small, non-coding RNAs that are associated with regulation of key cellular processes such as cell multiplication, differentiation, and death. They cause disturbance in the cell physiology by interfering directly with the translation and stability of a targeted gene transcript. MicroRNAs (miRNAs) constitute large family of non-coding RNAs which regulate target gene expression and protein levels that affect several human diseases and are suggested as the novel markers or therapeutic targets, including breast cancer. MicroRNA (miRNA) alterations are not only associated with metastasis, tumor genesis but also used as biomarkers for breast cancer diagnosis or prognosis. These are explained in detail in the following review. This review will also provide an impetus for more studies on the role of microRNAs in breast cancer.

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http://hdl.handle.net/10453/142608