Responders to Exercise Therapy in Patients with Osteoarthritis of the Hip: A Systematic Review and Meta-Analysis.

Teirlinck, CH; Verhagen, AP; Reijneveld, EAE; Runhaar, J; van Middelkoop, M; van Ravesteyn, LM; Hermsen, L; de Groot, IB; Bierma-Zeinstra, SMA

Responders to Exercise Therapy in Patients with Osteoarthritis of the Hip: A Systematic Review and Meta-Analysis.

Teirlinck, CH Verhagen, AP Reijneveld, EAE Runhaar, J van Middelkoop, M van Ravesteyn, LM Hermsen, L de Groot, IB Bierma-Zeinstra, SMA

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Publisher:: MDPI AG
Publication Type:: Journal Article
Citation:: International journal of environmental research and public health, 2020, 17, (20)
Issue Date:: 2020-10-10

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Field	Value	Language
dc.contributor.author	Teirlinck, CH
dc.contributor.author	Verhagen, AP
dc.contributor.author	Reijneveld, EAE
dc.contributor.author	Runhaar, J
dc.contributor.author	van Middelkoop, M
dc.contributor.author	van Ravesteyn, LM
dc.contributor.author	Hermsen, L
dc.contributor.author	de Groot, IB
dc.contributor.author	Bierma-Zeinstra, SMA
dc.date.accessioned	2020-10-19T04:10:54Z
dc.date.available	2020-10-04
dc.date.available	2020-10-19T04:10:54Z
dc.date.issued	2020-10-10
dc.identifier.citation	International journal of environmental research and public health, 2020, 17, (20)
dc.identifier.issn	1661-7827
dc.identifier.issn	1660-4601
dc.identifier.uri	http://hdl.handle.net/10453/143361
dc.description.abstract	The Outcome Measures in Rheumatology workgroup (OMERACT), together with the Osteoarthritis Research Society International (OARSI) developed the OMERACT-OARSI responder criteria. These criteria are used to determine if a patient with osteoarthritis (OA) 'responds' to therapy, meaning experiences a clinically relevant effect of therapy. Recently, more clinical OA trials report on this outcome and most OA trials have data to calculate the number of responders according to these criteria. A systematic review and meta-analysis were performed on the response to exercise therapy, compared to no or minimal intervention in patients with hip OA using the OMERACT-OARSI responder criteria. The literature was searched for relevant randomized trials. If a trial fit the inclusion criteria, but number of responders was not reported, the first author was contacted. This way the numbers of responders of 14 trials were collected and a meta-analysis on short term (directly after treatment, 12 trials n = 1178) and long term (6-8 months after treatment, six trials n = 519) outcomes was performed. At short term, the risk difference (RD) was 0.14 (95% confidence interval (CI) 0.06-0.22) and number needed to treat (NNT) 7.1 (95% CI 4.5-17); at long term RD was 0.14 (95% CI 0.07-0.20) and NNT 7.1 (95% CI 5.0-14.3). Quality of evidence was moderate for the short term and high for the long term. In conclusion, 14% more hip OA patients responded to exercise therapy than to no therapy.
dc.format	Electronic
dc.language	eng
dc.publisher	MDPI AG
dc.relation.ispartof	International journal of environmental research and public health
dc.relation.isbasedon	10.3390/ijerph17207380
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.classification	Toxicology
dc.title	Responders to Exercise Therapy in Patients with Osteoarthritis of the Hip: A Systematic Review and Meta-Analysis.
dc.type	Journal Article
utslib.citation.volume	17
utslib.location.activity	Switzerland
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Physiotherapy
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2020-10-19T04:10:47Z
pubs.issue	20
pubs.publication-status	Published
pubs.volume	17
utslib.citation.issue	20

Abstract:

The Outcome Measures in Rheumatology workgroup (OMERACT), together with the Osteoarthritis Research Society International (OARSI) developed the OMERACT-OARSI responder criteria. These criteria are used to determine if a patient with osteoarthritis (OA) 'responds' to therapy, meaning experiences a clinically relevant effect of therapy. Recently, more clinical OA trials report on this outcome and most OA trials have data to calculate the number of responders according to these criteria. A systematic review and meta-analysis were performed on the response to exercise therapy, compared to no or minimal intervention in patients with hip OA using the OMERACT-OARSI responder criteria. The literature was searched for relevant randomized trials. If a trial fit the inclusion criteria, but number of responders was not reported, the first author was contacted. This way the numbers of responders of 14 trials were collected and a meta-analysis on short term (directly after treatment, 12 trials n = 1178) and long term (6-8 months after treatment, six trials n = 519) outcomes was performed. At short term, the risk difference (RD) was 0.14 (95% confidence interval (CI) 0.06-0.22) and number needed to treat (NNT) 7.1 (95% CI 4.5-17); at long term RD was 0.14 (95% CI 0.07-0.20) and NNT 7.1 (95% CI 5.0-14.3). Quality of evidence was moderate for the short term and high for the long term. In conclusion, 14% more hip OA patients responded to exercise therapy than to no therapy.

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http://hdl.handle.net/10453/143361