Overcoming the dissolution rate, gastrointestinal permeability and oral bioavailability of glimepiride and simvastatin co-delivered in the form of nanosuspension and solid self-nanoemulsifying drug delivery system: A comparative study

Pandey, NK; Singh, SK; Gulati, M; Kumar, B; Kapoor, B; Ghosh, D; Kumar, R; Khursheed, R; Awasthi, A; Kuppusamy, G; Wadhwa, S; Satija, S; Dureja, H; Jain, SK; Chellappan, DK; Anand, K; Mehta, M; Dua, K

Overcoming the dissolution rate, gastrointestinal permeability and oral bioavailability of glimepiride and simvastatin co-delivered in the form of nanosuspension and solid self-nanoemulsifying drug delivery system: A comparative study

Pandey, NK Singh, SK Gulati, M Kumar, B Kapoor, B Ghosh, D Kumar, R Khursheed, R Awasthi, A Kuppusamy, G Wadhwa, S Satija, S

Dureja, H Jain, SK Chellappan, DK Anand, K Mehta, M Dua, K

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Publisher:: Elsevier BV
Publication Type:: Journal Article
Citation:: Journal of Drug Delivery Science and Technology, 2020, 60
Issue Date:: 2020-12-01

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Field	Value	Language
dc.contributor.author	Pandey, NK
dc.contributor.author	Singh, SK
dc.contributor.author	Gulati, M
dc.contributor.author	Kumar, B
dc.contributor.author	Kapoor, B
dc.contributor.author	Ghosh, D
dc.contributor.author	Kumar, R
dc.contributor.author	Khursheed, R
dc.contributor.author	Awasthi, A
dc.contributor.author	Kuppusamy, G
dc.contributor.author	Wadhwa, S
dc.contributor.author	Satija, S https://orcid.org/0000-0003-4702-6534
dc.contributor.author	Dureja, H
dc.contributor.author	Jain, SK
dc.contributor.author	Chellappan, DK
dc.contributor.author	Anand, K
dc.contributor.author	Mehta, M
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.date.accessioned	2020-10-23T01:15:33Z
dc.date.available	2020-10-23T01:15:33Z
dc.date.issued	2020-12-01
dc.identifier.citation	Journal of Drug Delivery Science and Technology, 2020, 60
dc.identifier.issn	1773-2247
dc.identifier.issn	1157-1489
dc.identifier.uri	http://hdl.handle.net/10453/143487
dc.description.abstract	© 2020 Elsevier B.V. Simvastatin (SIM) and glimepiride (GLM) were co-formulated into nanosuspensions and self-nanoemulsifying drug delivery systems (SNEDDS) to improve their dissolution rate and oral bioavailability. Nanosuspension was prepared by liquid anti-solvent precipitation method, involving supersaturation of a solution by mixing the drug solution in an antisolvent. Liquid SNEDDS were prepared by loading drugs into an isotropic mixture of Capmul MCM, Labrafil M1944CS, Tween-80 and Transcutol P. Both formulations were solidified using spray drying. Enhancement in dissolution rate by 6.4 folds and 4.45 folds was observed for GLM and SIM respectively by preparing their nano-formulations. Drugs’ permeability was also enhanced by loading them into nano-formulations. The pharmacokinetic studies were conducted on rats which revealed increase in oral bioavailability by 6.69- and 4.22-folds for GLM and 1.76- and 2.68-folds for SIM respectively for nanosuspension and solid SNEDDS than their unprocessed forms. Both dissolution rate and oral bioavailability of SIM and GLM got significantly improved through S-SNEDDS and nanosuspension. However, performance of nanosuspension was found better than SNEDDS in terms of dissolution rate and oral bioavailability.
dc.language	en
dc.publisher	Elsevier BV
dc.relation.ispartof	Journal of Drug Delivery Science and Technology
dc.relation.isbasedon	10.1016/j.jddst.2020.102083
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Pharmacology & Pharmacy
dc.title	Overcoming the dissolution rate, gastrointestinal permeability and oral bioavailability of glimepiride and simvastatin co-delivered in the form of nanosuspension and solid self-nanoemulsifying drug delivery system: A comparative study
dc.type	Journal Article
utslib.citation.volume	60
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2020-10-23T01:14:51Z
pubs.publication-status	Accepted
pubs.volume	60

Abstract:

© 2020 Elsevier B.V. Simvastatin (SIM) and glimepiride (GLM) were co-formulated into nanosuspensions and self-nanoemulsifying drug delivery systems (SNEDDS) to improve their dissolution rate and oral bioavailability. Nanosuspension was prepared by liquid anti-solvent precipitation method, involving supersaturation of a solution by mixing the drug solution in an antisolvent. Liquid SNEDDS were prepared by loading drugs into an isotropic mixture of Capmul MCM, Labrafil M1944CS, Tween-80 and Transcutol P. Both formulations were solidified using spray drying. Enhancement in dissolution rate by 6.4 folds and 4.45 folds was observed for GLM and SIM respectively by preparing their nano-formulations. Drugs’ permeability was also enhanced by loading them into nano-formulations. The pharmacokinetic studies were conducted on rats which revealed increase in oral bioavailability by 6.69- and 4.22-folds for GLM and 1.76- and 2.68-folds for SIM respectively for nanosuspension and solid SNEDDS than their unprocessed forms. Both dissolution rate and oral bioavailability of SIM and GLM got significantly improved through S-SNEDDS and nanosuspension. However, performance of nanosuspension was found better than SNEDDS in terms of dissolution rate and oral bioavailability.

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http://hdl.handle.net/10453/143487