Analysis of high-dimensional genomic data using MapReduce based probabilistic neural network.

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Journal Article
Computer methods and programs in biomedicine, 2020, 195, pp. 105625
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BACKGROUND:The size of genomics data has been growing rapidly over the last decade. However, the conventional data analysis techniques are incapable of processing this huge amount of data. For the efficient processing of high dimensional datasets, it is essential to develop some new parallel methods. METHODS:In this work, a novel distributed method is presented using Map-Reduce (MR)-based approach. The proposed algorithm consists of MR-based Fisher score (mrFScore), MR-based ReliefF (mrRefiefF), and MR-based probabilistic neural network (mrPNN) using a weighted chaotic grey wolf optimization technique (WCGWO). Here, mrFScore, and mrRefiefF methods are introduced for feature selection (FS), and mrPNN is implemented as an effective method for microarray classification. The proper choice of smoothing parameter (σ) plays a major role in the prediction ability of the PNN which is addressed using a novel technique namely, WCGWO. The WCGWO algorithm is used to select the optimal value of σ in PNN. RESULTS:These algorithms have been successfully implemented using the Hadoop framework. The proposed model is tested by using three large and one small microarray datasets, and a comparative analysis is carried out with the existing FS and classification techniques. The results suggest that WCGWO-mrPNN can outperform other methods for high dimensional microarray classification. CONCLUSION:The effectiveness of the proposed methods are compared with other existing schemes. Experimental results reveal that the proposed scheme is accurate and robust. Hence, the suggested scheme is considered to be a reliable framework for microarray data analysis. SIGNIFICANCE:Such a method promotes the application of parallel programming using Hadoop cluster for the analysis of large-scale genomics data, particularly when the dataset is of high dimension.
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