Emerging concepts and directed therapeutics for the management of asthma: regulating the regulators.

Shastri, MD; Chong, WC; Dua, K; Peterson, GM; Patel, RP; Mahmood, MQ; Tambuwala, M; Chellappan, DK; Hansbro, NG; Shukla, SD; Hansbro, PM

Emerging concepts and directed therapeutics for the management of asthma: regulating the regulators.

Shastri, MD Chong, WC Dua, K

Peterson, GM Patel, RP Mahmood, MQ Tambuwala, M Chellappan, DK Hansbro, NG Shukla, SD Hansbro, PM

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Publisher:: Springer Science and Business Media LLC
Publication Type:: Journal Article
Citation:: Inflammopharmacology, 2020, pp. 1-19
Issue Date:: 2020-11-05

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Field	Value	Language
dc.contributor.author	Shastri, MD
dc.contributor.author	Chong, WC
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Peterson, GM
dc.contributor.author	Patel, RP
dc.contributor.author	Mahmood, MQ
dc.contributor.author	Tambuwala, M
dc.contributor.author	Chellappan, DK
dc.contributor.author	Hansbro, NG
dc.contributor.author	Shukla, SD
dc.contributor.author	Hansbro, PM
dc.date.accessioned	2020-11-20T05:02:19Z
dc.date.available	2020-10-17
dc.date.available	2020-11-20T05:02:19Z
dc.date.issued	2020-11-05
dc.identifier.citation	Inflammopharmacology, 2020, pp. 1-19
dc.identifier.issn	0925-4692
dc.identifier.issn	1568-5608
dc.identifier.uri	http://hdl.handle.net/10453/144196
dc.description.abstract	Asthma is a common, heterogeneous and serious disease, its prevalence has steadily risen in most parts of the world, and the condition is often inadequately controlled in many patients. Hence, there is a major need for new therapeutic approaches. Mild-to-moderate asthma is considered a T-helper cell type-2-mediated inflammatory disorder that develops due to abnormal immune responses to otherwise innocuous allergens. Prolonged exposure to allergens and persistent inflammation results in myofibroblast infiltration and airway remodelling with mucus hypersecretion, airway smooth muscle hypertrophy, and excess collagen deposition. The airways become hyper-responsive to provocation resulting in the characteristic wheezing and obstructed airflow experienced by patients. Extensive research has progressed the understanding of the underlying mechanisms and the development of new treatments for the management of asthma. Here, we review the basis of the disease, covering new areas such as the role of vascularisation and microRNAs, as well as associated potential therapeutic interventions utilising reports from animal and human studies. We also cover novel drug delivery strategies that are being developed to enhance therapeutic efficacy and patient compliance. Potential avenues to explore to improve the future of asthma management are highlighted.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Springer Science and Business Media LLC
dc.relation	http://purl.org/au-research/grants/nhmrc/GNT1079187
dc.relation	http://purl.org/au-research/grants/nhmrc/1175134
dc.relation.ispartof	Inflammopharmacology
dc.relation.isbasedon	10.1007/s10787-020-00770-y
dc.rights	This is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: http://dx.doi.org/[insert DOI]”
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	This is a post-peer-review, pre-copyedit version of an article published in Inflammopharmacology. The final authenticated version is available online at: https://dx.doi.org/10.1007/s10787-020-00770-y.	en_US
dc.subject	1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Pharmacology & Pharmacy
dc.title	Emerging concepts and directed therapeutics for the management of asthma: regulating the regulators.
dc.type	Journal Article
utslib.location.activity	Switzerland
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access	*
dc.date.updated	2020-11-20T05:02:08Z
pubs.publication-status	Published

Abstract:

Asthma is a common, heterogeneous and serious disease, its prevalence has steadily risen in most parts of the world, and the condition is often inadequately controlled in many patients. Hence, there is a major need for new therapeutic approaches. Mild-to-moderate asthma is considered a T-helper cell type-2-mediated inflammatory disorder that develops due to abnormal immune responses to otherwise innocuous allergens. Prolonged exposure to allergens and persistent inflammation results in myofibroblast infiltration and airway remodelling with mucus hypersecretion, airway smooth muscle hypertrophy, and excess collagen deposition. The airways become hyper-responsive to provocation resulting in the characteristic wheezing and obstructed airflow experienced by patients. Extensive research has progressed the understanding of the underlying mechanisms and the development of new treatments for the management of asthma. Here, we review the basis of the disease, covering new areas such as the role of vascularisation and microRNAs, as well as associated potential therapeutic interventions utilising reports from animal and human studies. We also cover novel drug delivery strategies that are being developed to enhance therapeutic efficacy and patient compliance. Potential avenues to explore to improve the future of asthma management are highlighted.

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http://hdl.handle.net/10453/144196