Clinical trials knowledge and attitudes of Vietnamese- and Anglo-Australian cancer patients: A cross-sectional study.

Smith, AB; Niu, AY; Descallar, J; Delaney, GP; Wu, VS; Agar, MR; Girgis, A

Clinical trials knowledge and attitudes of Vietnamese- and Anglo-Australian cancer patients: A cross-sectional study.

Smith, AB Niu, AY Descallar, J Delaney, GP Wu, VS Agar, MR Girgis, A

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Publisher:: Wiley
Publication Type:: Journal Article
Citation:: Asia-Pacific journal of clinical oncology, 2020, 16, (5), pp. e242-e251
Issue Date:: 2020-10

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Field	Value	Language
dc.contributor.author	Smith, AB
dc.contributor.author	Niu, AY
dc.contributor.author	Descallar, J
dc.contributor.author	Delaney, GP
dc.contributor.author	Wu, VS
dc.contributor.author	Agar, MR
dc.contributor.author	Girgis, A
dc.date.accessioned	2020-11-22T19:24:36Z
dc.date.available	2020-05-13
dc.date.available	2020-11-22T19:24:36Z
dc.date.issued	2020-10
dc.identifier.citation	Asia-Pacific journal of clinical oncology, 2020, 16, (5), pp. e242-e251
dc.identifier.issn	1743-7555
dc.identifier.issn	1743-7563
dc.identifier.uri	http://hdl.handle.net/10453/144218
dc.description.abstract	AIM:Low participation in cancer clinical trials by culturally and linguistically diverse (CALD) patients limits access to cutting-edge treatments and generalizability of results. This is the first study exploring trials knowledge/attitudes and their association with trial participation in Vietnamese- and Anglo-Australian cancer patients. METHODS:Eligible patients diagnosed with cancer in the past 10 years were invited to complete a self-report questionnaire comprising validated measures of: trials knowledge and attitudes, preferred information amount, preferred decision-making involvement, health literacy, and past and future (i.e. hypothetical) trial participation. Multivariable linear regression evaluated correlates of trials knowledge/attitudes. Multinomial logistic regression estimated the relationship between trials knowledge/attitudes and possible future trial participation. RESULTS:Vietnamese-Australian participants (n = 50) had more negative attitudes regarding trials than Anglo-Australians (n = 100; B = -9.28; 95% confidence interval [CI], -17.60 to -0.97; P = 0.029), but similar knowledge (B = -0.91; 95% CI, -2.27 to 0.44; P = 0.18). Future trial participation was associated with positive attitudes (odds ratio [OR] = 1.08; 95% CI, 1.04-1.12; P < 0.001) and greater knowledge (OR = 1.30; 95% CI, 1.04-1.62; P = 0.02), but not Vietnamese background (OR = 0.95; 95% CI, 0.27-3.32; P = 0.93). CONCLUSION:Despite poorer attitudes regarding trials in Vietnamese-Australians, Vietnamese background was not associated with less likely future trial participation, suggesting low trial participation by CALD patients may be more due to opportunity barriers. Improving knowledge and attitudes may increase trial participation generally.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Wiley
dc.relation.ispartof	Asia-Pacific journal of clinical oncology
dc.relation.isbasedon	10.1111/ajco.13388
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1112 Oncology and Carcinogenesis
dc.subject.classification	Oncology & Carcinogenesis
dc.subject.mesh	Humans
dc.subject.mesh	Neoplasms
dc.subject.mesh	Cross-Sectional Studies
dc.subject.mesh	Attitude
dc.subject.mesh	Aged
dc.subject.mesh	Middle Aged
dc.subject.mesh	Patient Participation
dc.subject.mesh	Vietnam
dc.subject.mesh	Australia
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.subject.mesh	Aged
dc.subject.mesh	Attitude
dc.subject.mesh	Australia
dc.subject.mesh	Cross-Sectional Studies
dc.subject.mesh	Female
dc.subject.mesh	Humans
dc.subject.mesh	Male
dc.subject.mesh	Middle Aged
dc.subject.mesh	Neoplasms
dc.subject.mesh	Patient Participation
dc.subject.mesh	Vietnam
dc.title	Clinical trials knowledge and attitudes of Vietnamese- and Anglo-Australian cancer patients: A cross-sectional study.
dc.type	Journal Article
utslib.citation.volume	16
utslib.location.activity	Australia
utslib.for	1112 Oncology and Carcinogenesis
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/IMPACCT
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	closed_access	*
dc.date.updated	2020-11-22T19:24:32Z
pubs.issue	5
pubs.publication-status	Published
pubs.volume	16
utslib.citation.issue	5

Abstract:

AIM:Low participation in cancer clinical trials by culturally and linguistically diverse (CALD) patients limits access to cutting-edge treatments and generalizability of results. This is the first study exploring trials knowledge/attitudes and their association with trial participation in Vietnamese- and Anglo-Australian cancer patients. METHODS:Eligible patients diagnosed with cancer in the past 10 years were invited to complete a self-report questionnaire comprising validated measures of: trials knowledge and attitudes, preferred information amount, preferred decision-making involvement, health literacy, and past and future (i.e. hypothetical) trial participation. Multivariable linear regression evaluated correlates of trials knowledge/attitudes. Multinomial logistic regression estimated the relationship between trials knowledge/attitudes and possible future trial participation. RESULTS:Vietnamese-Australian participants (n = 50) had more negative attitudes regarding trials than Anglo-Australians (n = 100; B = -9.28; 95% confidence interval [CI], -17.60 to -0.97; P = 0.029), but similar knowledge (B = -0.91; 95% CI, -2.27 to 0.44; P = 0.18). Future trial participation was associated with positive attitudes (odds ratio [OR] = 1.08; 95% CI, 1.04-1.12; P < 0.001) and greater knowledge (OR = 1.30; 95% CI, 1.04-1.62; P = 0.02), but not Vietnamese background (OR = 0.95; 95% CI, 0.27-3.32; P = 0.93). CONCLUSION:Despite poorer attitudes regarding trials in Vietnamese-Australians, Vietnamese background was not associated with less likely future trial participation, suggesting low trial participation by CALD patients may be more due to opportunity barriers. Improving knowledge and attitudes may increase trial participation generally.

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http://hdl.handle.net/10453/144218