SARS CoV-2 aggravates cellular metabolism mediated complications in COVID-19 infection.

Singh, Y; Gupta, G; Kazmi, I; Al-Abbasi, FA; Negi, P; Chellappan, DK; Dua, K

SARS CoV-2 aggravates cellular metabolism mediated complications in COVID-19 infection.

Singh, Y Gupta, G Kazmi, I Al-Abbasi, FA Negi, P Chellappan, DK Dua, K

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Publisher:: WILEY
Publication Type:: Journal Article
Citation:: Dermatologic therapy, 2020, pp. e13871
Issue Date:: 2020-06-18

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Field	Value	Language
dc.contributor.author	Singh, Y
dc.contributor.author	Gupta, G
dc.contributor.author	Kazmi, I
dc.contributor.author	Al-Abbasi, FA
dc.contributor.author	Negi, P
dc.contributor.author	Chellappan, DK
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.date.accessioned	2020-11-24T04:52:16Z
dc.date.available	2020-06-16
dc.date.available	2020-11-24T04:52:16Z
dc.date.issued	2020-06-18
dc.identifier.citation	Dermatologic therapy, 2020, pp. e13871
dc.identifier.issn	1396-0296
dc.identifier.issn	1529-8019
dc.identifier.uri	http://hdl.handle.net/10453/144311
dc.description.abstract	Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the primary causative organism in corona virus disease-19 (COVID-19) infections, is a novel member of the human coronavirus family which was first identified in Wuhan, China, towards the end of 2019. This letter reveals new vital missing links in our current understanding of the mechanisms that lead to cell death triggered by ferroptotic stress in COVID-19 infection. It further reveal the importance of homocysteine mediated trans-sulfuration pathway in COVID-19 infection. Hence, Vitamin B6, folic acid, and Vitamin B12 should be incorporated in the treatment regimen for SARS CoV-2 infections to suppress complications, as the virus mediates altered host cell metabolism.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	WILEY
dc.relation.ispartof	Dermatologic therapy
dc.relation.isbasedon	10.1111/dth.13871
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1103 Clinical Sciences
dc.subject.classification	Dermatology & Venereal Diseases
dc.title	SARS CoV-2 aggravates cellular metabolism mediated complications in COVID-19 infection.
dc.type	Journal Article
utslib.location.activity	United States
utslib.for	1103 Clinical Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
utslib.copyright.status	open_access	*
dc.date.updated	2020-11-24T04:52:03Z
pubs.publication-status	Published

Abstract:

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the primary causative organism in corona virus disease-19 (COVID-19) infections, is a novel member of the human coronavirus family which was first identified in Wuhan, China, towards the end of 2019. This letter reveals new vital missing links in our current understanding of the mechanisms that lead to cell death triggered by ferroptotic stress in COVID-19 infection. It further reveal the importance of homocysteine mediated trans-sulfuration pathway in COVID-19 infection. Hence, Vitamin B6, folic acid, and Vitamin B12 should be incorporated in the treatment regimen for SARS CoV-2 infections to suppress complications, as the virus mediates altered host cell metabolism.

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http://hdl.handle.net/10453/144311