| Field |
Value |
Language |
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dc.contributor.author |
Nuzzo, JL |
|
|
dc.contributor.author |
Kennedy, DS |
|
|
dc.contributor.author |
Finn, HT |
|
|
dc.contributor.author |
Taylor, JL |
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|
dc.date.accessioned |
2020-12-08T04:15:41Z |
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|
dc.date.available |
2020-12-08T04:15:41Z |
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dc.identifier.citation |
Journal of Applied Physiology |
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|
dc.identifier.issn |
8750-7587 |
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|
dc.identifier.issn |
1522-1601 |
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|
dc.identifier.uri |
http://hdl.handle.net/10453/144546
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|
dc.description.abstract |
<jats:p> We examined if transcranial magnetic stimulation (TMS) is a valid tool for assessment of voluntary activation of the knee extensors in healthy individuals. Maximal M-waves (M<jats:sub>max</jats:sub>) of vastus lateralis (VL) were evoked with electrical stimulation of femoral nerve (FNS); M<jats:sub>max</jats:sub> of medial hamstrings (HS) was evoked with electrical stimulation of sciatic nerve branches; motor evoked potentials (MEPs) of VL and HS were evoked with TMS; superimposed twitches (SIT) of knee extensors were evoked with FNS and TMS. In Study 1, TMS intensity (69% output(SD 5)) was optimized for MEP sizes, but guidelines for test validity could not be met. Agonist VL MEPs were too small (51.4% M<jats:sub>max</jats:sub>(SD 11.9); guideline ≥70% M<jats:sub>max</jats:sub>) and antagonist HS MEPs were too big (16.5% M<jats:sub>max</jats:sub>(SD 10.3); guideline <10% M<jats:sub>max</jats:sub>). Consequently, the TMS estimated resting twitch (99.1 N(SD 37.2)) and FNS resting twitch (142.4 N(SD 41.8)) were different. In Study 2, SITs at 90% maximal voluntary contraction (MVC) were similar between TMS (16.1 N(SD 10.3)) and FNS (20.9 N(SD 16.7)), when TMS intensity was optimized for this purpose, suggesting a procedure that combines TMS SITs with FNS resting twitches could be valid. In Study 3, which tested the TMS intensity (56% output(SD 18)) that evoked the largest SIT at 90%MVC, voluntary activation from TMS (87.3%(SD 7.1)) and FNS (84.5%(SD 7.6)) were different. In sum, the contemporary procedure for TMS-based voluntary activation of the knee extensors is invalid. A modified procedure improves validity, but only in individuals who meet rigorous inclusion criteria for SITs and MEPs. </jats:p> |
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dc.language |
en |
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dc.publisher |
American Physiological Society |
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dc.relation.ispartof |
Journal of Applied Physiology |
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dc.relation.isbasedon |
10.1152/japplphysiol.00717.2020 |
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dc.rights |
The following article has been submitted to/accepted by [Journal of Applied Physiology]. After it is published, it will be found at (https://journals.physiology.org/doi/abs/10.1152/japplphysiol.00717.2020). |
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dc.rights |
info:eu-repo/semantics/embargoedAccess |
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dc.subject |
06 Biological Sciences, 11 Medical and Health Sciences |
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|
dc.subject.classification |
Physiology |
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|
dc.title |
Voluntary activation of knee extensor muscles with transcranial magnetic stimulation |
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dc.type |
Journal Article |
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|
utslib.for |
06 Biological Sciences |
|
|
utslib.for |
11 Medical and Health Sciences |
|
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pubs.organisational-group |
/University of Technology Sydney/Faculty of Health |
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|
pubs.organisational-group |
/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Physiotherapy |
|
|
pubs.organisational-group |
/University of Technology Sydney |
|
|
pubs.organisational-group |
/University of Technology Sydney/Faculty of Health/Graduate School of Health |
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utslib.copyright.status |
open_access |
* |
|
utslib.copyright.embargo |
2021-12-03T00:00:00+1000Z |
|
|
dc.date.updated |
2020-12-08T04:15:33Z |
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pubs.publication-status |
Published online |
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