Role of lung microbiome in innate immune response associated with chronic lung diseases

Paudel, KR; Dharwal, V; Patel, V; Galvao, I; Wadhwa, R; Malyla, V; Shen, S; Budden, KF; Hansbro, N; Bebawy, M; Dua, K; Hansbro, P

Role of lung microbiome in innate immune response associated with chronic lung diseases

Paudel, KR Dharwal, V

Patel, V Galvao, I

Wadhwa, R Malyla, V Shen, S

Budden, KF Hansbro, N Bebawy, M

Dua, K

Hansbro, P

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Publisher:: Frontiers Media
Publication Type:: Journal Article
Citation:: Frontiers in Medicine, 2020, 7, pp. 554
Issue Date:: 2020

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Field	Value	Language
dc.contributor.author	Paudel, KR
dc.contributor.author	Dharwal, V https://orcid.org/0000-0002-9645-3797
dc.contributor.author	Patel, V
dc.contributor.author	Galvao, I https://orcid.org/0000-0002-9943-8349
dc.contributor.author	Wadhwa, R
dc.contributor.author	Malyla, V
dc.contributor.author	Shen, S https://orcid.org/0000-0002-1004-1936
dc.contributor.author	Budden, KF
dc.contributor.author	Hansbro, N
dc.contributor.author	Bebawy, M https://orcid.org/0000-0003-2606-921X
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Hansbro, P https://orcid.org/0000-0002-4741-3035
dc.date.accessioned	2020-12-22T23:14:44Z
dc.date.available	2020-08-03
dc.date.available	2020-12-22T23:14:44Z
dc.date.issued	2020
dc.identifier.citation	Frontiers in Medicine, 2020, 7, pp. 554
dc.identifier.issn	2296-858X
dc.identifier.issn	2296-858X
dc.identifier.uri	http://hdl.handle.net/10453/144920
dc.description.abstract	Respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), lung fibrosis, and lung cancer, pose a huge socio-economic burden on society and are one of the leading causes of death worldwide. In the past, culture-dependent techniques could not detect bacteria in the lungs, therefore the lungs were considered a sterile environment. However, the development of culture-independent techniques, particularly 16S rRNA sequencing, allowed for the detection of commensal microbes in the lung and with further investigation, their roles in disease have since emerged. In healthy individuals, the predominant commensal microbes are of phylum Firmicutes and Bacteroidetes, including those of the genera Veillonella and Prevotella. In contrast, pathogenic microbes (Haemophilus, Streptococcus, Klebsiella, Pseudomonas) are often associated with lung diseases. There is growing evidence that microbial metabolites, structural components, and toxins from pathogenic and opportunistic bacteria have the capacity to stimulate both innate and adaptive immune responses, and therefore can contribute to the pathogenesis of lung diseases. Here we review the multiple mechanisms that are altered by pathogenic microbiomes in asthma, COPD, lung cancer, and lung fibrosis. Furthermore, we focus on the recent exciting advancements in therapies that can be used to restore altered microbiomes in the lungs.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	Frontiers Media
dc.relation	http://purl.org/au-research/grants/nhmrc/1175134
dc.relation.ispartof	Frontiers in Medicine
dc.relation.isbasedon	10.3389/fmed.2020.00554
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Role of lung microbiome in innate immune response associated with chronic lung diseases
dc.type	Journal Article
utslib.citation.volume	7
utslib.location.activity	Switzerland
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2020-12-22T23:14:33Z
pubs.publication-status	Accepted
pubs.volume	7

Abstract:

Respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), lung fibrosis, and lung cancer, pose a huge socio-economic burden on society and are one of the leading causes of death worldwide. In the past, culture-dependent techniques could not detect bacteria in the lungs, therefore the lungs were considered a sterile environment. However, the development of culture-independent techniques, particularly 16S rRNA sequencing, allowed for the detection of commensal microbes in the lung and with further investigation, their roles in disease have since emerged. In healthy individuals, the predominant commensal microbes are of phylum Firmicutes and Bacteroidetes, including those of the genera Veillonella and Prevotella. In contrast, pathogenic microbes (Haemophilus, Streptococcus, Klebsiella, Pseudomonas) are often associated with lung diseases. There is growing evidence that microbial metabolites, structural components, and toxins from pathogenic and opportunistic bacteria have the capacity to stimulate both innate and adaptive immune responses, and therefore can contribute to the pathogenesis of lung diseases. Here we review the multiple mechanisms that are altered by pathogenic microbiomes in asthma, COPD, lung cancer, and lung fibrosis. Furthermore, we focus on the recent exciting advancements in therapies that can be used to restore altered microbiomes in the lungs.

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http://hdl.handle.net/10453/144920