Curcumin-loaded niosomes downregulate mRNA expression of pro-inflammatory markers involved in asthma: an in vitro study.

Jin-Ying Wong; Yin Ng, Z; Mehta, M; Shukla, SD; Panneerselvam, J; Madheswaran, T; Gupta, G; Negi, P; Kumar, P; Pillay, V; Hsu, A; Hansbro, NG; Wark, P; Bebawy, M; Hansbro, PM; Dua, K; Chellappan, DK

Curcumin-loaded niosomes downregulate mRNA expression of pro-inflammatory markers involved in asthma: an in vitro study.

Jin-Ying Wong Yin Ng, Z Mehta, M Shukla, SD Panneerselvam, J Madheswaran, T Gupta, G Negi, P Kumar, P Pillay, V Hsu, A Hansbro, NG Wark, P Bebawy, M

Hansbro, PM Dua, K

Chellappan, DK

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Publisher:: Future Medicine Ltd
Publication Type:: Journal Article
Citation:: Nanomedicine (London, England), 2020, 0, (0)
Issue Date:: 2020-11-30

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Field	Value	Language
dc.contributor.author	Jin-Ying Wong
dc.contributor.author	Yin Ng, Z
dc.contributor.author	Mehta, M
dc.contributor.author	Shukla, SD
dc.contributor.author	Panneerselvam, J
dc.contributor.author	Madheswaran, T
dc.contributor.author	Gupta, G
dc.contributor.author	Negi, P
dc.contributor.author	Kumar, P
dc.contributor.author	Pillay, V
dc.contributor.author	Hsu, A
dc.contributor.author	Hansbro, NG
dc.contributor.author	Wark, P
dc.contributor.author	Bebawy, M https://orcid.org/0000-0003-2606-921X
dc.contributor.author	Hansbro, PM
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Chellappan, DK
dc.date.accessioned	2020-12-22T23:17:55Z
dc.date.available	2020-12-22T23:17:55Z
dc.date.issued	2020-11-30
dc.identifier.citation	Nanomedicine (London, England), 2020, 0, (0)
dc.identifier.issn	1743-5889
dc.identifier.issn	1748-6963
dc.identifier.uri	http://hdl.handle.net/10453/144922
dc.description.abstract	Aim: In this study, curcumin was encapsulated in niosomes (Nio-Curc) to increase its effectiveness for the treatment of asthma. Materials & methods: The formulation underwent various physicochemical characterization experiments, an in vitro release study, molecular simulations and was evaluated for in vitro anti-inflammatory activity. Results: Results showed that Nio-Curc had a mean particle size of 284.93 ± 14.27 nm, zeta potential of -46.93 and encapsulation efficacy of 99.62%, which demonstrates optimized physicochemical characteristics. Curcumin release in vitro could be sustained for up to 24 h. Additionally, Nio-Curc effectively reduced mRNA transcript expression of pro-inflammatory markers; IL-6, IL-8, IL-1β and TNF-α in immortalized human airway basal cell line (BCi-NS1.1). Conclusion: In this study, we have demonstrated that Nio-Curc mitigated the mRNA expression of pro-inflammatory markers in an in vitro study, which could be applied to treatment of asthma with further studies.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Future Medicine Ltd
dc.relation.ispartof	Nanomedicine (London, England)
dc.relation.isbasedon	10.2217/nnm-2020-0260
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0306 Physical Chemistry (incl. Structural), 1004 Medical Biotechnology, 1007 Nanotechnology
dc.subject.classification	Nanoscience & Nanotechnology
dc.title	Curcumin-loaded niosomes downregulate mRNA expression of pro-inflammatory markers involved in asthma: an in vitro study.
dc.type	Journal Article
utslib.citation.volume	0
utslib.location.activity	England
utslib.for	0306 Physical Chemistry (incl. Structural)
utslib.for	1004 Medical Biotechnology
utslib.for	1007 Nanotechnology
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access	*
dc.date.updated	2020-12-22T23:17:39Z
pubs.issue	0
pubs.publication-status	Published
pubs.volume	0
utslib.citation.issue	0

Abstract:

Aim: In this study, curcumin was encapsulated in niosomes (Nio-Curc) to increase its effectiveness for the treatment of asthma. Materials & methods: The formulation underwent various physicochemical characterization experiments, an in vitro release study, molecular simulations and was evaluated for in vitro anti-inflammatory activity. Results: Results showed that Nio-Curc had a mean particle size of 284.93 ± 14.27 nm, zeta potential of -46.93 and encapsulation efficacy of 99.62%, which demonstrates optimized physicochemical characteristics. Curcumin release in vitro could be sustained for up to 24 h. Additionally, Nio-Curc effectively reduced mRNA transcript expression of pro-inflammatory markers; IL-6, IL-8, IL-1β and TNF-α in immortalized human airway basal cell line (BCi-NS1.1). Conclusion: In this study, we have demonstrated that Nio-Curc mitigated the mRNA expression of pro-inflammatory markers in an in vitro study, which could be applied to treatment of asthma with further studies.

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http://hdl.handle.net/10453/144922