Antiproliferative effects of boswellic acids-loaded chitosan nanoparticles on human lung cancer cell line A549.

Solanki, N; Mehta, M; Chellappan, DK; Gupta, G; Hansbro, NG; Tambuwala, MM; Aa Aljabali, A; Paudel, KR; Liu, G; Satija, S; Hansbro, PM; Dua, K; Dureja, H

Antiproliferative effects of boswellic acids-loaded chitosan nanoparticles on human lung cancer cell line A549.

Solanki, N Mehta, M Chellappan, DK Gupta, G Hansbro, NG Tambuwala, MM Aa Aljabali, A Paudel, KR Liu, G

Satija, S

Hansbro, PM Dua, K

Dureja, H

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Publisher:: Future Science
Publication Type:: Journal Article
Citation:: Future Medicinal Chemistry, 2020, 12, (22), pp. 2019-2034
Issue Date:: 2020-10-30

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Field	Value	Language
dc.contributor.author	Solanki, N
dc.contributor.author	Mehta, M
dc.contributor.author	Chellappan, DK
dc.contributor.author	Gupta, G
dc.contributor.author	Hansbro, NG
dc.contributor.author	Tambuwala, MM
dc.contributor.author	Aa Aljabali, A
dc.contributor.author	Paudel, KR
dc.contributor.author	Liu, G https://orcid.org/0000-0002-0489-2638
dc.contributor.author	Satija, S https://orcid.org/0000-0003-4702-6534
dc.contributor.author	Hansbro, PM
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Dureja, H
dc.date.accessioned	2020-12-22T23:19:14Z
dc.date.available	2020-12-22T23:19:14Z
dc.date.issued	2020-10-30
dc.identifier.citation	Future Medicinal Chemistry, 2020, 12, (22), pp. 2019-2034
dc.identifier.issn	1756-8919
dc.identifier.issn	1756-8927
dc.identifier.uri	http://hdl.handle.net/10453/144923
dc.description.abstract	Aim: In the present study boswellic acids-loaded chitosan nanoparticles were synthesized using ionic gelation technique. The influence of independent variables were studied and optimized on dependent variables using central composite design. Methodology/results: The designed nanoparticles were observed spherical in shape with an average size of 67.5-187.2 nm and have also shown an excellent entrapment efficiency (80.06 ± 0.48). The cytotoxicity assay revealed enhanced cytotoxicity for drug-loaded nanoparticles in contrast to the free drug having an IC50 value of 17.29 and 29.59 μM, respectively. Flow cytometry confirmed that treatment of cells with 40 μg/ml had arrested 22.75 ± 0.3% at SubG0 phase of the cell cycle when compared with untreated A459 cells. The observed results justified the boswellic acids-loaded chitosan nanoparticles were effective due to greater cellular uptake, sustained intercellular drug retention and enhanced antiproliferative effect by inducing apoptosis.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Future Science
dc.relation.ispartof	Future Medicinal Chemistry
dc.relation.isbasedon	10.4155/fmc-2020-0083
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0304 Medicinal and Biomolecular Chemistry, 1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Medicinal & Biomolecular Chemistry
dc.title	Antiproliferative effects of boswellic acids-loaded chitosan nanoparticles on human lung cancer cell line A549.
dc.type	Journal Article
utslib.citation.volume	12
utslib.location.activity	England
utslib.for	0304 Medicinal and Biomolecular Chemistry
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2020-12-22T23:19:01Z
pubs.issue	22
pubs.publication-status	Published
pubs.volume	12
utslib.citation.issue	22

Abstract:

Aim: In the present study boswellic acids-loaded chitosan nanoparticles were synthesized using ionic gelation technique. The influence of independent variables were studied and optimized on dependent variables using central composite design. Methodology/results: The designed nanoparticles were observed spherical in shape with an average size of 67.5-187.2 nm and have also shown an excellent entrapment efficiency (80.06 ± 0.48). The cytotoxicity assay revealed enhanced cytotoxicity for drug-loaded nanoparticles in contrast to the free drug having an IC50 value of 17.29 and 29.59 μM, respectively. Flow cytometry confirmed that treatment of cells with 40 μg/ml had arrested 22.75 ± 0.3% at SubG0 phase of the cell cycle when compared with untreated A459 cells. The observed results justified the boswellic acids-loaded chitosan nanoparticles were effective due to greater cellular uptake, sustained intercellular drug retention and enhanced antiproliferative effect by inducing apoptosis.

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http://hdl.handle.net/10453/144923