Advancing of Cellular Signaling Pathways in Respiratory Diseases Using Nanocarrier based Drug Delivery Systems.

Mehta, M; Dhanjal, DS; Satija, S; Wadhwa, R; Paudel, KR; Chellappan, DK; Mohammad, S; Haghi, M; Hansbro, PM; Dua, K

Advancing of Cellular Signaling Pathways in Respiratory Diseases Using Nanocarrier based Drug Delivery Systems.

Mehta, M Dhanjal, DS Satija, S

Wadhwa, R Paudel, KR Chellappan, DK Mohammad, S Haghi, M

Hansbro, PM Dua, K

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Publisher:: Bentham Science Publishers Ltd.
Publication Type:: Journal Article
Citation:: Current pharmaceutical design, 2020, 26, (42), pp. 5380-5392
Issue Date:: 2020-11-16

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Field	Value	Language
dc.contributor.author	Mehta, M
dc.contributor.author	Dhanjal, DS
dc.contributor.author	Satija, S https://orcid.org/0000-0003-4702-6534
dc.contributor.author	Wadhwa, R
dc.contributor.author	Paudel, KR
dc.contributor.author	Chellappan, DK
dc.contributor.author	Mohammad, S
dc.contributor.author	Haghi, M https://orcid.org/0000-0002-3362-1845
dc.contributor.author	Hansbro, PM
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.date.accessioned	2020-12-22T23:20:32Z
dc.date.available	2021-08-12T19:00:58Z
dc.date.issued	2020-11-16
dc.identifier.citation	Current pharmaceutical design, 2020, 26, (42), pp. 5380-5392
dc.identifier.issn	1381-6128
dc.identifier.issn	1873-4286
dc.identifier.uri	http://hdl.handle.net/10453/144924
dc.description.abstract	Cell Signaling pathways form an integral part of our existence, that allows the cells to comprehend a stimulus and respond back. Such reactions, to external cues from the environment, are required and are essential to regulate the normal functioning of our body. Abnormalities in the system arise when there are errors developed in these signals, resulting in a complication or a disease. Presently, respiratory diseases contribute to being the third leading cause of morbidity worldwide. According to the current statistics, over 339 million people who are asthmatic, 65 million who are suffering from COPD, 2.3 million who are lung cancer patients and 10 million are tuberculosis patients. This toll of statistics with chronic respiratory diseases leaves a heavy burden on society and nation annual health expenditure. Hence, a better understanding of the processes governing these cellular pathways will enable us to treat and manage these deadly respiratory diseases effectively. Moreover, it is important to comprehend the synergy and interplay of the cellular signaling pathways in respiratory diseases, which will enable us to explore and develop suitable strategies for targeted drug delivery. This review, in particular, focuses on the major respiratory diseases and further provides an in-depth discussion on the various cell signaling pathways that are involved in the pathophysiology of respiratory diseases. Moreover, the review also analyses the defining concepts about advanced nano-drug delivery systems involving various nanocarriers and propose newer prospects to minimize the current challenges faced by researchers and formulation scientists.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Bentham Science Publishers Ltd.
dc.relation	Maridulu Budyari Gumal - The Sydney Partnership for Health, Education, Research and Enterprise (SPHERE)TRIPLE I CAG SECONDMENT / EXCHANGE
dc.relation.ispartof	Current pharmaceutical design
dc.relation.isbasedon	10.2174/1381612826999201116161143
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.subject	1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Medicinal & Biomolecular Chemistry
dc.title	Advancing of Cellular Signaling Pathways in Respiratory Diseases Using Nanocarrier based Drug Delivery Systems.
dc.type	Journal Article
utslib.citation.volume	26
utslib.location.activity	United Arab Emirates
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access	*
dc.date.updated	2020-12-22T23:20:18Z
pubs.issue	42
pubs.publication-status	Published
pubs.volume	26
utslib.citation.issue	42

Abstract:

Cell Signaling pathways form an integral part of our existence, that allows the cells to comprehend a stimulus and respond back. Such reactions, to external cues from the environment, are required and are essential to regulate the normal functioning of our body. Abnormalities in the system arise when there are errors developed in these signals, resulting in a complication or a disease. Presently, respiratory diseases contribute to being the third leading cause of morbidity worldwide. According to the current statistics, over 339 million people who are asthmatic, 65 million who are suffering from COPD, 2.3 million who are lung cancer patients and 10 million are tuberculosis patients. This toll of statistics with chronic respiratory diseases leaves a heavy burden on society and nation annual health expenditure. Hence, a better understanding of the processes governing these cellular pathways will enable us to treat and manage these deadly respiratory diseases effectively. Moreover, it is important to comprehend the synergy and interplay of the cellular signaling pathways in respiratory diseases, which will enable us to explore and develop suitable strategies for targeted drug delivery. This review, in particular, focuses on the major respiratory diseases and further provides an in-depth discussion on the various cell signaling pathways that are involved in the pathophysiology of respiratory diseases. Moreover, the review also analyses the defining concepts about advanced nano-drug delivery systems involving various nanocarriers and propose newer prospects to minimize the current challenges faced by researchers and formulation scientists.

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http://hdl.handle.net/10453/144924