Opening eyes to therapeutic perspectives of bioactive polyphenols and their nanoformulations against diabetic neuropathy and related complications.

Khursheed, R; Singh, SK; Wadhwa, S; Gulati, M; Kapoor, B; Awasthi, A; Kr, A; Kumar, R; Pottoo, FH; Kumar, V; Dureja, H; Anand, K; Chellappan, DK; Dua, K; Gowthamarajan, K

Opening eyes to therapeutic perspectives of bioactive polyphenols and their nanoformulations against diabetic neuropathy and related complications.

Khursheed, R Singh, SK Wadhwa, S Gulati, M Kapoor, B Awasthi, A Kr, A Kumar, R Pottoo, FH Kumar, V Dureja, H Anand, K Chellappan, DK Dua, K

Gowthamarajan, K

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Publisher:: Informa UK Limited
Publication Type:: Journal Article
Citation:: Expert opinion on drug delivery, 2020, pp. 1-22
Issue Date:: 2020-12-27

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Field	Value	Language
dc.contributor.author	Khursheed, R
dc.contributor.author	Singh, SK
dc.contributor.author	Wadhwa, S
dc.contributor.author	Gulati, M
dc.contributor.author	Kapoor, B
dc.contributor.author	Awasthi, A
dc.contributor.author	Kr, A
dc.contributor.author	Kumar, R
dc.contributor.author	Pottoo, FH
dc.contributor.author	Kumar, V
dc.contributor.author	Dureja, H
dc.contributor.author	Anand, K
dc.contributor.author	Chellappan, DK
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Gowthamarajan, K
dc.date.accessioned	2021-01-07T03:11:21Z
dc.date.available	2021-01-07T03:11:21Z
dc.date.issued	2020-12-27
dc.identifier.citation	Expert opinion on drug delivery, 2020, pp. 1-22
dc.identifier.issn	1742-5247
dc.identifier.issn	1744-7593
dc.identifier.uri	http://hdl.handle.net/10453/145156
dc.description.abstract	<b>Introduction</b>: Diabetic neuropathy (DN) is one of the major complications arising from hyperglycaemia in diabetic patients. In recent years polyphenols present in plants have gained attention to treat DN. The main advantages associated with them are their action via different molecular pathways to manage DN and their safety. However, they failed to gain clinical attention due to challenges associated with their formulation development such as lipophilicity,poor bioavailability, rapid systemic elimination, and enzymatic degradation. <b>Area covered</b>: This article includes different polyphenols that have shown their potential against DN in preclinical studies and the research carried out towards development of their nanoformulations in order to overcome aforementioned issues. <b>Expert opinion</b>: In this review various polyphenol based nanoformulations such as nanospheres, self-nanoemulsifying drug delivery systems, niosomes, electrospun nanofibers, metallic nanoparticles explored exclusively to treat DN are discussed. However, the literature available related to polyphenol based nanoformulations to treat DN is limited. Moreover, these experiments are limited to preclinical studies. Hence, more focus is required towards development of nanoformulations using simple and single step process as well as inexpensive and non-toxic excipients so that a stable, scalable, reproducible and non-toxic formulation could be achieved and clinical trials could be initiated.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Informa UK Limited
dc.relation.ispartof	Expert opinion on drug delivery
dc.relation.isbasedon	10.1080/17425247.2021.1846517
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1115 Pharmacology and Pharmaceutical Sciences
dc.title	Opening eyes to therapeutic perspectives of bioactive polyphenols and their nanoformulations against diabetic neuropathy and related complications.
dc.type	Journal Article
utslib.location.activity	England
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
utslib.copyright.status	closed_access	*
dc.date.updated	2021-01-07T03:11:09Z
pubs.publication-status	Published

Abstract:

Introduction: Diabetic neuropathy (DN) is one of the major complications arising from hyperglycaemia in diabetic patients. In recent years polyphenols present in plants have gained attention to treat DN. The main advantages associated with them are their action via different molecular pathways to manage DN and their safety. However, they failed to gain clinical attention due to challenges associated with their formulation development such as lipophilicity,poor bioavailability, rapid systemic elimination, and enzymatic degradation. Area covered: This article includes different polyphenols that have shown their potential against DN in preclinical studies and the research carried out towards development of their nanoformulations in order to overcome aforementioned issues. Expert opinion: In this review various polyphenol based nanoformulations such as nanospheres, self-nanoemulsifying drug delivery systems, niosomes, electrospun nanofibers, metallic nanoparticles explored exclusively to treat DN are discussed. However, the literature available related to polyphenol based nanoformulations to treat DN is limited. Moreover, these experiments are limited to preclinical studies. Hence, more focus is required towards development of nanoformulations using simple and single step process as well as inexpensive and non-toxic excipients so that a stable, scalable, reproducible and non-toxic formulation could be achieved and clinical trials could be initiated.

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http://hdl.handle.net/10453/145156