Beyond the Obvious: Smoking and Respiratory Infection Implications on Alzheimer's Disease.

Wadhwa, R; Paudel, KR; Mehta, M; Shukla, SD; Sunkara, K; Prasher, P; Panth, N; Goyal, R; Chellappan, DK; Gupta, G; Hansbro, PM; Aljabali, AAA; Tambuwala, MM; Dua, K

Beyond the Obvious: Smoking and Respiratory Infection Implications on Alzheimer's Disease.

Wadhwa, R Paudel, KR Mehta, M Shukla, SD Sunkara, K Prasher, P Panth, N Goyal, R Chellappan, DK Gupta, G Hansbro, PM Aljabali, AAA Tambuwala, MM Dua, K

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Publisher:: BENTHAM SCIENCE PUBL
Publication Type:: Journal Article
Citation:: CNS & neurological disorders drug targets, 2020, 19, (9), pp. 698-708
Issue Date:: 2020-01

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Field	Value	Language
dc.contributor.author	Wadhwa, R
dc.contributor.author	Paudel, KR
dc.contributor.author	Mehta, M
dc.contributor.author	Shukla, SD
dc.contributor.author	Sunkara, K
dc.contributor.author	Prasher, P
dc.contributor.author	Panth, N
dc.contributor.author	Goyal, R
dc.contributor.author	Chellappan, DK
dc.contributor.author	Gupta, G
dc.contributor.author	Hansbro, PM
dc.contributor.author	Aljabali, AAA
dc.contributor.author	Tambuwala, MM
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.date.accessioned	2021-02-25T04:52:24Z
dc.date.available	2020-04-28
dc.date.available	2021-02-25T04:52:24Z
dc.date.issued	2020-01
dc.identifier.citation	CNS & neurological disorders drug targets, 2020, 19, (9), pp. 698-708
dc.identifier.issn	1871-5273
dc.identifier.issn	1996-3181
dc.identifier.uri	http://hdl.handle.net/10453/146456
dc.description.abstract	Tobacco smoke is not only a leading cause for chronic obstructive pulmonary disease, cardiovascular disorders, and lung and oral cancers, but also causes neurological disorders such as Alzheimer 's disease. Tobacco smoke consists of more than 4500 toxic chemicals, which form free radicals and can cross blood-brain barrier resulting in oxidative stress, an extracellular amyloid plaque from the aggregation of amyloid β (Aβ) peptide deposition in the brain. Further, respiratory infections such as Chlamydia pneumoniae, respiratory syncytial virus have also been involved in the induction and development of the disease. The necessary information collated on this review has been gathered from various literature published from 1995 to 2019. The review article sheds light on the role of smoking and respiratory infections in causing oxidative stress and neuroinflammation, resulting in Alzheimer's disease (AD). This review will be of interest to scientists and researchers from biological and medical science disciplines, including microbiology, pharmaceutical sciences and the translational researchers, etc. The increasing understanding of the relationship between chronic lung disease and neurological disease is two-fold. First, this would help to identify the risk factors and possible therapeutic interventions to reduce the development and progression of both diseases. Second, this would help to reduce the probable risk of development of AD in the population prone to chronic lung diseases.
dc.format	Print
dc.language	eng
dc.publisher	BENTHAM SCIENCE PUBL
dc.relation.ispartof	CNS & neurological disorders drug targets
dc.relation.isbasedon	10.2174/1871527319999200817112427
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1109 Neurosciences, 1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Neurology & Neurosurgery
dc.title	Beyond the Obvious: Smoking and Respiratory Infection Implications on Alzheimer's Disease.
dc.type	Journal Article
utslib.citation.volume	19
utslib.location.activity	United Arab Emirates
utslib.for	1109 Neurosciences
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access	*
dc.date.updated	2021-02-25T04:52:22Z
pubs.issue	9
pubs.publication-status	Published
pubs.volume	19
utslib.citation.issue	9

Abstract:

Tobacco smoke is not only a leading cause for chronic obstructive pulmonary disease, cardiovascular disorders, and lung and oral cancers, but also causes neurological disorders such as Alzheimer 's disease. Tobacco smoke consists of more than 4500 toxic chemicals, which form free radicals and can cross blood-brain barrier resulting in oxidative stress, an extracellular amyloid plaque from the aggregation of amyloid β (Aβ) peptide deposition in the brain. Further, respiratory infections such as Chlamydia pneumoniae, respiratory syncytial virus have also been involved in the induction and development of the disease. The necessary information collated on this review has been gathered from various literature published from 1995 to 2019. The review article sheds light on the role of smoking and respiratory infections in causing oxidative stress and neuroinflammation, resulting in Alzheimer's disease (AD). This review will be of interest to scientists and researchers from biological and medical science disciplines, including microbiology, pharmaceutical sciences and the translational researchers, etc. The increasing understanding of the relationship between chronic lung disease and neurological disease is two-fold. First, this would help to identify the risk factors and possible therapeutic interventions to reduce the development and progression of both diseases. Second, this would help to reduce the probable risk of development of AD in the population prone to chronic lung diseases.

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http://hdl.handle.net/10453/146456