Oxidative Stress and Immunological Complexities in Multidrug-Resistant Tuberculosis

Wadhwa, R; Sehgal, N; G, N; Aggarwal, T; Satija, S; Mehta, M; Gupta, G; Chellappan, DK; Tambuwala, MM; Oliver, B; Collet, T; Maurya, PK; Hansbro, PM; Dua, K

Oxidative Stress and Immunological Complexities in Multidrug-Resistant Tuberculosis

Wadhwa, R Sehgal, N G, N Aggarwal, T Satija, S

Mehta, M Gupta, G Chellappan, DK Tambuwala, MM Oliver, B

Collet, T Maurya, PK Hansbro, PM Dua, K

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Publisher:: Springer Nature
Publication Type:: Chapter
Citation:: Role of Oxidative Stress in Pathophysiology of Diseases, 2020, 1, pp. 107-124
Issue Date:: 2020-06-16

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Field	Value	Language
dc.contributor.author	Wadhwa, R
dc.contributor.author	Sehgal, N
dc.contributor.author	G, N
dc.contributor.author	Aggarwal, T
dc.contributor.author	Satija, S https://orcid.org/0000-0003-4702-6534
dc.contributor.author	Mehta, M
dc.contributor.author	Gupta, G
dc.contributor.author	Chellappan, DK
dc.contributor.author	Tambuwala, MM
dc.contributor.author	Oliver, B https://orcid.org/0000-0002-7122-9262
dc.contributor.author	Collet, T
dc.contributor.author	Maurya, PK
dc.contributor.author	Hansbro, PM
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.date.accessioned	2021-03-02T00:42:25Z
dc.date.available	2021-03-02T00:42:25Z
dc.date.issued	2020-06-16
dc.identifier.citation	Role of Oxidative Stress in Pathophysiology of Diseases, 2020, 1, pp. 107-124
dc.identifier.isbn	9811515689
dc.identifier.isbn	9789811515682
dc.identifier.uri	http://hdl.handle.net/10453/146611
dc.description.abstract	© Springer Nature Singapore Pte Ltd. 2020. Mycobacterium tuberculosis (Mtb), the causitive agent of Tuberculosis (TB) is the leading cause of infection. The infection is caused by aerosols and infects the alveolar macrophage. The lungs counteract against the infection by the antioxidant system in response to the oxidative stress (OS) caused. Mycobacteriumstimulates the lung macrophage to produce reactive oxygen species (ROS). Furthermore, the treatment involves long term multiple drug regimens resulting in poor patient compliance leading to multidrug resistance (MDR-TB). The different first-line and second-line antibiotics are administered in an inactive form which gets converted into the active form by the OS response system of the host and the Mtb. Mtb alters the redox balance via mycolic acid, NADH/NAD+ ratio, and antioxidant enzymes in response to stress. In the following chapter, we have discussed the role of oxidative stress in the host and the pathogen along with the immunological complexities and the genetic modifications resulting in multidrug-resistant tuberculosis. It also discusses the different strategies to target the Mtb infection.
dc.language	en
dc.publisher	Springer Nature
dc.relation.ispartof	Role of Oxidative Stress in Pathophysiology of Diseases
dc.relation.isbasedon	10.1007/978-981-15-1568-2_7
dc.rights	info:eu-repo/semantics/closedAccess
dc.title	Oxidative Stress and Immunological Complexities in Multidrug-Resistant Tuberculosis
dc.type	Chapter
utslib.citation.edition	1
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2021-03-02T00:42:22Z
pubs.edition	1
pubs.place-of-publication	Singapore
pubs.publication-status	Published
dc.location	Singapore

Abstract:

© Springer Nature Singapore Pte Ltd. 2020. Mycobacterium tuberculosis (Mtb), the causitive agent of Tuberculosis (TB) is the leading cause of infection. The infection is caused by aerosols and infects the alveolar macrophage. The lungs counteract against the infection by the antioxidant system in response to the oxidative stress (OS) caused. Mycobacteriumstimulates the lung macrophage to produce reactive oxygen species (ROS). Furthermore, the treatment involves long term multiple drug regimens resulting in poor patient compliance leading to multidrug resistance (MDR-TB). The different first-line and second-line antibiotics are administered in an inactive form which gets converted into the active form by the OS response system of the host and the Mtb. Mtb alters the redox balance via mycolic acid, NADH/NAD+ ratio, and antioxidant enzymes in response to stress. In the following chapter, we have discussed the role of oxidative stress in the host and the pathogen along with the immunological complexities and the genetic modifications resulting in multidrug-resistant tuberculosis. It also discusses the different strategies to target the Mtb infection.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/146611