Molecular and Immunological Mechanisms Underlying the Various Pharmacological Properties of the Potent Bioflavonoid, Rutin.

Yong, DOC; Saker, SR; Chellappan, DK; Madheswaran, T; Panneerselvam, J; Choudhury, H; Pandey, M; Chan, YL; Collet, T; Gupta, G; Oliver, BG; Wark, P; Hansbro, N; Hsu, A; Hansbro, PM; Dua, K; Zeeshan, F

Molecular and Immunological Mechanisms Underlying the Various Pharmacological Properties of the Potent Bioflavonoid, Rutin.

Yong, DOC Saker, SR Chellappan, DK Madheswaran, T Panneerselvam, J Choudhury, H Pandey, M Chan, YL Collet, T Gupta, G Oliver, BG Wark, P Hansbro, N Hsu, A Hansbro, PM Dua, K

Zeeshan, F

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Publisher:: Bentham Science Publishers
Publication Type:: Journal Article
Citation:: Endocrine, Metabolic and Immune Disorders: Drug Targets, 2020, 20, (10), pp. 1590-1596
Issue Date:: 2020-01

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Field	Value	Language
dc.contributor.author	Yong, DOC
dc.contributor.author	Saker, SR
dc.contributor.author	Chellappan, DK
dc.contributor.author	Madheswaran, T
dc.contributor.author	Panneerselvam, J
dc.contributor.author	Choudhury, H
dc.contributor.author	Pandey, M
dc.contributor.author	Chan, YL
dc.contributor.author	Collet, T
dc.contributor.author	Gupta, G
dc.contributor.author	Oliver, BG
dc.contributor.author	Wark, P
dc.contributor.author	Hansbro, N
dc.contributor.author	Hsu, A
dc.contributor.author	Hansbro, PM
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Zeeshan, F
dc.date.accessioned	2021-03-03T21:32:18Z
dc.date.available	2019-06-13
dc.date.available	2021-03-03T21:32:18Z
dc.date.issued	2020-01
dc.identifier.citation	Endocrine, Metabolic and Immune Disorders: Drug Targets, 2020, 20, (10), pp. 1590-1596
dc.identifier.issn	1871-5303
dc.identifier.issn	2212-3873
dc.identifier.uri	http://hdl.handle.net/10453/146727
dc.description.abstract	The application of medicinal plants has captured the interest of researchers in recent times due to their potent therapeutic properties and a better safety profile. The prominent role of herbal products in treating and preventing multiple diseases dates back to ancient history and most of the modern drugs today originated from their significant sources owing to their ability to control multiple targets via different signalling pathways. Among them, flavonoids consist of a large group of polyphenols, which are well known for their various therapeutic benefits. Rutin is considered one of the attractive phytochemicals and important flavonoids in the pharmaceutical industry due to its diverse pharmacological activities via various underlying molecular mechanisms. It is usually prescribed for various disease conditions such as varicosities, haemorrhoids and internal haemorrhage. In this review, we have discussed and highlighted the different molecular mechanisms attributed to the various pharmacological activities of rutin, such as antioxidant, anti-inflammatory, anticancer, anti-allergic and antidiabetic. This review will be beneficial to herbal, biological and molecular scientists in understanding the pharmacological relevance of rutin at the molecular level.
dc.format	Print
dc.language	eng
dc.publisher	Bentham Science Publishers
dc.relation.ispartof	Endocrine, Metabolic and Immune Disorders: Drug Targets
dc.relation.isbasedon	10.2174/1871530320666200503053846
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1107 Immunology, 1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Immunology
dc.title	Molecular and Immunological Mechanisms Underlying the Various Pharmacological Properties of the Potent Bioflavonoid, Rutin.
dc.type	Journal Article
utslib.citation.volume	20
utslib.location.activity	United Arab Emirates
utslib.for	1107 Immunology
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
utslib.for	1107 Immunology
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
utslib.copyright.status	closed_access	*
pubs.consider-herdc	true
dc.date.updated	2021-03-03T21:32:17Z
pubs.issue	10
pubs.publication-status	Published
pubs.volume	20
utslib.citation.issue	10

Abstract:

The application of medicinal plants has captured the interest of researchers in recent times due to their potent therapeutic properties and a better safety profile. The prominent role of herbal products in treating and preventing multiple diseases dates back to ancient history and most of the modern drugs today originated from their significant sources owing to their ability to control multiple targets via different signalling pathways. Among them, flavonoids consist of a large group of polyphenols, which are well known for their various therapeutic benefits. Rutin is considered one of the attractive phytochemicals and important flavonoids in the pharmaceutical industry due to its diverse pharmacological activities via various underlying molecular mechanisms. It is usually prescribed for various disease conditions such as varicosities, haemorrhoids and internal haemorrhage. In this review, we have discussed and highlighted the different molecular mechanisms attributed to the various pharmacological activities of rutin, such as antioxidant, anti-inflammatory, anticancer, anti-allergic and antidiabetic. This review will be beneficial to herbal, biological and molecular scientists in understanding the pharmacological relevance of rutin at the molecular level.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/146727