The tumour bank at the children's hospital at westmead: An Australian paediatric cancer biorepository

Zhou, L; Yuksel, A; Markovich, O; Gabrael, N; Catchpoole, D

The tumour bank at the children's hospital at westmead: An Australian paediatric cancer biorepository

Zhou, L Yuksel, A Markovich, O Gabrael, N Catchpoole, D

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Publisher:: Ubiquity Press, Ltd.
Publication Type:: Journal Article
Citation:: Open Journal of Bioresources, 2020, 5, (0)
Issue Date:: 2020-01-01

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Field	Value	Language
dc.contributor.author	Zhou, L
dc.contributor.author	Yuksel, A
dc.contributor.author	Markovich, O
dc.contributor.author	Gabrael, N
dc.contributor.author	Catchpoole, D
dc.date.accessioned	2021-03-05T01:16:13Z
dc.date.available	2021-03-05T01:16:13Z
dc.date.issued	2020-01-01
dc.identifier.citation	Open Journal of Bioresources, 2020, 5, (0)
dc.identifier.issn	2056-5542
dc.identifier.issn	2056-5542
dc.identifier.uri	http://hdl.handle.net/10453/146793
dc.description.abstract	© 2018 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See http://creativecommons.org/licenses/by/4.0/. The Tumor Bank at The Children's Hospital at Westmead was established in 1998 with the purpose of facilitating research into childhood malignancy through the active provision of well annotated, ethically collected tissue samples and providing a pathway for the Children Hospital at Westmead to engage in leading research initiatives, supporting international investigations and clinical trials. Within 20 years practice as a single institute biorepository, The Tumour Bank has established standard operating procedures for collection of tissue, blood and bone marrow that were integrated into routine patient management systems. In addition, three main operational areas have been developed: collection of biospecimens and written consent; management of clinical data and biospecimen inventory database; and implementation of an open access policy to support childhood cancer research around the world. Regulatory oversight is provided by the Tumour Bank Committee, Human Research Ethics Committee and Governance Department. This concerted effort has resulted in collecting 20340 specimens from 3788 patients within 20 years, and The Tumour bank has supported over 108 national and international research projects, and contributed to over 70 peer-reviewed publications to date, with a mean time-to-publication of 19.1 ± 9.0 months and average Impact Factor of 6.11 ± 4.53. In conclusion, the Children's Hospital at Westmead Tumour Bank has demonstrated a sustained single institutional biorepository model for facilitating translational research of rare cancer. It has provided strong evidence that integration of a single institutional biobank into standard clinical practices would be the long-term pathway of valuable bio-resource for rare cancer research.
dc.language	en
dc.publisher	Ubiquity Press, Ltd.
dc.relation.ispartof	Open Journal of Bioresources
dc.relation.isbasedon	10.5334/OJB.34
dc.rights	info:eu-repo/semantics/openAccess
dc.title	The tumour bank at the children's hospital at westmead: An Australian paediatric cancer biorepository
dc.type	Journal Article
utslib.citation.volume	5
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	open_access	*
dc.date.updated	2021-03-05T01:16:11Z
pubs.issue	0
pubs.publication-status	Published
pubs.volume	5
utslib.citation.issue	0

Abstract:

© 2018 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See http://creativecommons.org/licenses/by/4.0/. The Tumor Bank at The Children's Hospital at Westmead was established in 1998 with the purpose of facilitating research into childhood malignancy through the active provision of well annotated, ethically collected tissue samples and providing a pathway for the Children Hospital at Westmead to engage in leading research initiatives, supporting international investigations and clinical trials. Within 20 years practice as a single institute biorepository, The Tumour Bank has established standard operating procedures for collection of tissue, blood and bone marrow that were integrated into routine patient management systems. In addition, three main operational areas have been developed: collection of biospecimens and written consent; management of clinical data and biospecimen inventory database; and implementation of an open access policy to support childhood cancer research around the world. Regulatory oversight is provided by the Tumour Bank Committee, Human Research Ethics Committee and Governance Department. This concerted effort has resulted in collecting 20340 specimens from 3788 patients within 20 years, and The Tumour bank has supported over 108 national and international research projects, and contributed to over 70 peer-reviewed publications to date, with a mean time-to-publication of 19.1 ± 9.0 months and average Impact Factor of 6.11 ± 4.53. In conclusion, the Children's Hospital at Westmead Tumour Bank has demonstrated a sustained single institutional biorepository model for facilitating translational research of rare cancer. It has provided strong evidence that integration of a single institutional biobank into standard clinical practices would be the long-term pathway of valuable bio-resource for rare cancer research.

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http://hdl.handle.net/10453/146793