Scalable fabrication of tunable titanium nanotubes via sonoelectrochemical process for biomedical applications.

Mansoorianfar, M; Khataee, A; Riahi, Z; Shahin, K; Asadnia, M; Razmjou, A; Hojjati-Najafabadi, A; Mei, C; Orooji, Y; Li, D

Scalable fabrication of tunable titanium nanotubes via sonoelectrochemical process for biomedical applications.

Mansoorianfar, M Khataee, A Riahi, Z Shahin, K Asadnia, M Razmjou, A Hojjati-Najafabadi, A Mei, C Orooji, Y Li, D

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Publisher:: ELSEVIER
Publication Type:: Journal Article
Citation:: Ultrasonics sonochemistry, 2020, 64
Issue Date:: 2020-06

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Field	Value	Language
dc.contributor.author	Mansoorianfar, M
dc.contributor.author	Khataee, A
dc.contributor.author	Riahi, Z
dc.contributor.author	Shahin, K
dc.contributor.author	Asadnia, M
dc.contributor.author	Razmjou, A
dc.contributor.author	Hojjati-Najafabadi, A
dc.contributor.author	Mei, C
dc.contributor.author	Orooji, Y
dc.contributor.author	Li, D
dc.date.accessioned	2021-03-16T23:45:42Z
dc.date.available	2019-09-06
dc.date.available	2021-03-16T23:45:42Z
dc.date.issued	2020-06
dc.identifier.citation	Ultrasonics sonochemistry, 2020, 64
dc.identifier.issn	1350-4177
dc.identifier.issn	1873-2828
dc.identifier.uri	http://hdl.handle.net/10453/147266
dc.description.abstract	Titanium does not react well with the human tissues and due to its bio-inert nature the surface modification has yet to be well-studied. In this study, the sonoelectrochemical process has been carried out to generate TiO<sub>2</sub> nanotube arrays on implantable Ti 6-4. All the prepared nanotubes fill with the vancomycin by immersion and electrophoresis method. Drug-releasing properties, antibacterial behavior, protein adsorption and cell attachment of drug-modified nanotubes are examined by UV-vis, flow cytometry, modified disc diffusion, BSA adsorption, and FESEM, respectively. The most uniform morphology, appropriate drug release, cell viability behavior and antibacterial properties can be achieved by samples anodized in the range of 60-75 V. Also improves the adsorption of BSA protein in bone healing and promotes osteoblast activity and osseointegration. Drug loading efficiency increases up to 60% via electrophoresis comparing the immersion method for anodized sample in 75 V. While electrophoresis does not affect the amount of vancomycin adsorption for lower voltages. Besides, the present study indicates that an anodized sample without drug loading has no antibacterial activity. Moreover, 28-days drug releasing from nanotubes is investigated by mathematical formula according to Fickian's law to find an effective dose of loaded drug.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	ELSEVIER
dc.relation.ispartof	Ultrasonics sonochemistry
dc.relation.isbasedon	10.1016/j.ultsonch.2019.104783
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0306 Physical Chemistry (incl. Structural), 0913 Mechanical Engineering
dc.subject.classification	Organic Chemistry
dc.subject.mesh	Anti-Bacterial Agents
dc.subject.mesh	Cell Line, Tumor
dc.subject.mesh	Cell Survival
dc.subject.mesh	Drug Carriers
dc.subject.mesh	Drug Liberation
dc.subject.mesh	Electrochemistry
dc.subject.mesh	Humans
dc.subject.mesh	Nanotechnology
dc.subject.mesh	Nanotubes
dc.subject.mesh	Osteoblasts
dc.subject.mesh	Titanium
dc.subject.mesh	Ultrasonic Waves
dc.subject.mesh	Cell Line, Tumor
dc.subject.mesh	Osteoblasts
dc.subject.mesh	Humans
dc.subject.mesh	Titanium
dc.subject.mesh	Drug Carriers
dc.subject.mesh	Anti-Bacterial Agents
dc.subject.mesh	Cell Survival
dc.subject.mesh	Electrochemistry
dc.subject.mesh	Nanotechnology
dc.subject.mesh	Nanotubes
dc.subject.mesh	Drug Liberation
dc.subject.mesh	Ultrasonic Waves
dc.subject.mesh	Anti-Bacterial Agents
dc.subject.mesh	Cell Line, Tumor
dc.subject.mesh	Cell Survival
dc.subject.mesh	Drug Carriers
dc.subject.mesh	Drug Liberation
dc.subject.mesh	Electrochemistry
dc.subject.mesh	Humans
dc.subject.mesh	Nanotechnology
dc.subject.mesh	Nanotubes
dc.subject.mesh	Osteoblasts
dc.subject.mesh	Titanium
dc.subject.mesh	Ultrasonic Waves
dc.title	Scalable fabrication of tunable titanium nanotubes via sonoelectrochemical process for biomedical applications.
dc.type	Journal Article
utslib.citation.volume	64
utslib.location.activity	Netherlands
utslib.for	0306 Physical Chemistry (incl. Structural)
utslib.for	0913 Mechanical Engineering
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Civil and Environmental Engineering
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2021-03-16T23:45:34Z
pubs.publication-status	Published
pubs.volume	64

Abstract:

Titanium does not react well with the human tissues and due to its bio-inert nature the surface modification has yet to be well-studied. In this study, the sonoelectrochemical process has been carried out to generate TiO₂ nanotube arrays on implantable Ti 6-4. All the prepared nanotubes fill with the vancomycin by immersion and electrophoresis method. Drug-releasing properties, antibacterial behavior, protein adsorption and cell attachment of drug-modified nanotubes are examined by UV-vis, flow cytometry, modified disc diffusion, BSA adsorption, and FESEM, respectively. The most uniform morphology, appropriate drug release, cell viability behavior and antibacterial properties can be achieved by samples anodized in the range of 60-75 V. Also improves the adsorption of BSA protein in bone healing and promotes osteoblast activity and osseointegration. Drug loading efficiency increases up to 60% via electrophoresis comparing the immersion method for anodized sample in 75 V. While electrophoresis does not affect the amount of vancomycin adsorption for lower voltages. Besides, the present study indicates that an anodized sample without drug loading has no antibacterial activity. Moreover, 28-days drug releasing from nanotubes is investigated by mathematical formula according to Fickian's law to find an effective dose of loaded drug.

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http://hdl.handle.net/10453/147266