Western herbal medicines in the treatment of irritable bowel syndrome: A systematic review and meta-analysis.

Hawrelak, JA; Wohlmuth, H; Pattinson, M; Myers, SP; Goldenberg, JZ; Harnett, J; Cooley, K; Van De Venter, C; Reid, R; Whitten, DL

Western herbal medicines in the treatment of irritable bowel syndrome: A systematic review and meta-analysis.

Hawrelak, JA Wohlmuth, H Pattinson, M Myers, SP Goldenberg, JZ Harnett, J Cooley, K Van De Venter, C Reid, R

Whitten, DL

Permalink

Publisher:: Elsevier BV
Publication Type:: Journal Article
Citation:: Complementary therapies in medicine, 2020, 48, pp. 102233
Issue Date:: 2020-01

Closed Access

	Filename	Description	Size
	1-s2.0-S0965229919308775-main.pdf	Published version	1.72 MB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Hawrelak, JA
dc.contributor.author	Wohlmuth, H
dc.contributor.author	Pattinson, M
dc.contributor.author	Myers, SP
dc.contributor.author	Goldenberg, JZ
dc.contributor.author	Harnett, J
dc.contributor.author	Cooley, K
dc.contributor.author	Van De Venter, C
dc.contributor.author	Reid, R https://orcid.org/0000-0002-3633-5465
dc.contributor.author	Whitten, DL
dc.date.accessioned	2021-04-05T04:43:32Z
dc.date.available	2019-10-29
dc.date.available	2021-04-05T04:43:32Z
dc.date.issued	2020-01
dc.identifier.citation	Complementary therapies in medicine, 2020, 48, pp. 102233
dc.identifier.issn	0965-2299
dc.identifier.issn	1873-6963
dc.identifier.uri	http://hdl.handle.net/10453/147829
dc.description.abstract	OBJECTIVE:To evaluate the efficacy of Western herbal medicines in the treatment of irritable bowel syndrome (IBS). DESIGN:A computer-based search of MEDLINE, EMBASE, CINAHL, AMED, GreenFILE, Health Source: Nursing/Academic Edition, and the Cochrane Library was conducted. A hand-search of the bibliographies of relevant papers and previous meta-analyses and reviews was also undertaken. Trials were included in the review if they were double-blind and placebo-controlled investigating the effects of Western herbal medicines on IBS-related symptoms or quality of life. There were no language restrictions. Eligibility assessment and data extraction were performed by two independent researchers. For herbal medicines where there was more than 1 trial of similar design, data were synthesised using relative risk of symptoms improving using the random effects model. RESULTS:Thirty-three trials were identified that met all eligibility criteria. Seventeen of these evaluated peppermint essential oil, fifteen other Western herbal medicines, and one trial evaluated peppermint oil in one arm and aniseed essential oil in the other arm. Eighteen different herbal preparations were evaluated in these trials. Data suggests that a number of Western herbal medicines may provide relief of IBS symptoms. Meta-analyses suggest that peppermint essential oil is both efficacious and well-tolerated in the short-term management of IBS. Aloe vera and asafoetida also demonstrated efficacy in reducing global IBS symptoms in meta-analyses. The herbal formulas STW 5, STW 5-II and Carmint, along with Ferula assa-foetida, Pimpenella anisum oil, the combination of Curcumin and Foeniculum vulgare oil, and the blend of Schinopsis lorentzii, Aesculus hippocastanum, and peppermint essential oil also demonstrated efficacy in rigorously-designed clinical trials. CONCLUSION:A number of Western herbal medicines show promise in the treatment of IBS. With the exception of peppermint essential oil, Aloe vera, and asafoetida, however, none of the positive trials have been replicated. This lack of replication limits the capacity to make definitive statements of efficacy for these herbal medicines.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier BV
dc.relation.ispartof	Complementary therapies in medicine
dc.relation.isbasedon	10.1016/j.ctim.2019.102233
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1104 Complementary and Alternative Medicine, 1701 Psychology
dc.subject.classification	Complementary & Alternative Medicine
dc.subject.mesh	Humans
dc.subject.mesh	Irritable Bowel Syndrome
dc.subject.mesh	Oils, Volatile
dc.subject.mesh	Plant Preparations
dc.subject.mesh	Complementary Therapies
dc.subject.mesh	Herbal Medicine
dc.subject.mesh	Complementary Therapies
dc.subject.mesh	Herbal Medicine
dc.subject.mesh	Humans
dc.subject.mesh	Irritable Bowel Syndrome
dc.subject.mesh	Oils, Volatile
dc.subject.mesh	Plant Preparations
dc.title	Western herbal medicines in the treatment of irritable bowel syndrome: A systematic review and meta-analysis.
dc.type	Journal Article
utslib.citation.volume	48
utslib.location.activity	Scotland
utslib.for	1104 Complementary and Alternative Medicine
utslib.for	1104 Complementary and Alternative Medicine
utslib.for	1701 Psychology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Public Health
utslib.copyright.status	closed_access	*
dc.date.updated	2021-04-05T04:43:30Z
pubs.publication-status	Published
pubs.volume	48

Abstract:

OBJECTIVE:To evaluate the efficacy of Western herbal medicines in the treatment of irritable bowel syndrome (IBS). DESIGN:A computer-based search of MEDLINE, EMBASE, CINAHL, AMED, GreenFILE, Health Source: Nursing/Academic Edition, and the Cochrane Library was conducted. A hand-search of the bibliographies of relevant papers and previous meta-analyses and reviews was also undertaken. Trials were included in the review if they were double-blind and placebo-controlled investigating the effects of Western herbal medicines on IBS-related symptoms or quality of life. There were no language restrictions. Eligibility assessment and data extraction were performed by two independent researchers. For herbal medicines where there was more than 1 trial of similar design, data were synthesised using relative risk of symptoms improving using the random effects model. RESULTS:Thirty-three trials were identified that met all eligibility criteria. Seventeen of these evaluated peppermint essential oil, fifteen other Western herbal medicines, and one trial evaluated peppermint oil in one arm and aniseed essential oil in the other arm. Eighteen different herbal preparations were evaluated in these trials. Data suggests that a number of Western herbal medicines may provide relief of IBS symptoms. Meta-analyses suggest that peppermint essential oil is both efficacious and well-tolerated in the short-term management of IBS. Aloe vera and asafoetida also demonstrated efficacy in reducing global IBS symptoms in meta-analyses. The herbal formulas STW 5, STW 5-II and Carmint, along with Ferula assa-foetida, Pimpenella anisum oil, the combination of Curcumin and Foeniculum vulgare oil, and the blend of Schinopsis lorentzii, Aesculus hippocastanum, and peppermint essential oil also demonstrated efficacy in rigorously-designed clinical trials. CONCLUSION:A number of Western herbal medicines show promise in the treatment of IBS. With the exception of peppermint essential oil, Aloe vera, and asafoetida, however, none of the positive trials have been replicated. This lack of replication limits the capacity to make definitive statements of efficacy for these herbal medicines.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/147829