Nucleic Acid Aptamers as a Potential Nucleus Targeted Drug Delivery System.

Shrivastava, G; Bakshi, HA; Aljabali, AA; Mishra, V; Hakkim, FL; Charbe, NB; Kesharwani, P; Chellappan, DK; Dua, K; Tambuwala, MM

Nucleic Acid Aptamers as a Potential Nucleus Targeted Drug Delivery System.

Shrivastava, G Bakshi, HA Aljabali, AA Mishra, V Hakkim, FL Charbe, NB Kesharwani, P Chellappan, DK Dua, K

Tambuwala, MM

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Publisher:: BENTHAM SCIENCE PUBL LTD
Publication Type:: Journal Article
Citation:: Current drug delivery, 2020, 17, (2), pp. 101-111
Issue Date:: 2020-01

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Field	Value	Language
dc.contributor.author	Shrivastava, G
dc.contributor.author	Bakshi, HA
dc.contributor.author	Aljabali, AA
dc.contributor.author	Mishra, V
dc.contributor.author	Hakkim, FL
dc.contributor.author	Charbe, NB
dc.contributor.author	Kesharwani, P
dc.contributor.author	Chellappan, DK
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Tambuwala, MM
dc.date.accessioned	2021-04-09T04:30:08Z
dc.date.available	2019-11-02
dc.date.available	2021-04-09T04:30:08Z
dc.date.issued	2020-01
dc.identifier.citation	Current drug delivery, 2020, 17, (2), pp. 101-111
dc.identifier.issn	1567-2018
dc.identifier.issn	1875-5704
dc.identifier.uri	http://hdl.handle.net/10453/147949
dc.description.abstract	BACKGROUND:Nucleus targeted drug delivery provides several opportunities for the treatment of fatal diseases such as cancer. However, the complex nucleocytoplasmic barriers pose significant challenges for delivering a drug directly and efficiently into the nucleus. Aptamers representing singlestranded DNA and RNA qualify as next-generation highly advanced and personalized medicinal agents that successfully inhibit the expression of certain proteins; possess extraordinary gene-expression for manoeuvring the diseased cell's fate with negligible toxicity. In addition, the precisely directed aptamers to the site of action present a tremendous potential to reach the nucleus by escaping the ensuing barriers to exhibit a better drug activity and gene expression. OBJECTIVE:This review epigrammatically highlights the significance of targeted drug delivery and presents a comprehensive description of the principal barriers faced by the nucleus targeted drug delivery paradigm and ensuing complexities thereof. Eventually, the progress of nucleus targeting with nucleic acid aptamers and success achieved so far have also been reviewed. METHODS:Systematic literature search was conducted of research published to date in the field of nucleic acid aptamers. CONCLUSION:The review specifically points out the contribution of individual aptamers as the nucleustargeting agent rather than aptamers in conjugated form.
dc.format	Print
dc.language	eng
dc.publisher	BENTHAM SCIENCE PUBL LTD
dc.relation.ispartof	Current drug delivery
dc.relation.isbasedon	10.2174/1567201817666200106104332
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Pharmacology & Pharmacy
dc.subject.mesh	Animals
dc.subject.mesh	Aptamers, Nucleotide
dc.subject.mesh	Cell Nucleus
dc.subject.mesh	Drug Delivery Systems
dc.subject.mesh	Humans
dc.subject.mesh	Cell Nucleus
dc.subject.mesh	Animals
dc.subject.mesh	Humans
dc.subject.mesh	Drug Delivery Systems
dc.subject.mesh	Aptamers, Nucleotide
dc.subject.mesh	Animals
dc.subject.mesh	Aptamers, Nucleotide
dc.subject.mesh	Cell Nucleus
dc.subject.mesh	Drug Delivery Systems
dc.subject.mesh	Humans
dc.title	Nucleic Acid Aptamers as a Potential Nucleus Targeted Drug Delivery System.
dc.type	Journal Article
utslib.citation.volume	17
utslib.location.activity	United Arab Emirates
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2021-04-09T04:30:06Z
pubs.issue	2
pubs.publication-status	Published
pubs.volume	17
utslib.citation.issue	2

Abstract:

BACKGROUND:Nucleus targeted drug delivery provides several opportunities for the treatment of fatal diseases such as cancer. However, the complex nucleocytoplasmic barriers pose significant challenges for delivering a drug directly and efficiently into the nucleus. Aptamers representing singlestranded DNA and RNA qualify as next-generation highly advanced and personalized medicinal agents that successfully inhibit the expression of certain proteins; possess extraordinary gene-expression for manoeuvring the diseased cell's fate with negligible toxicity. In addition, the precisely directed aptamers to the site of action present a tremendous potential to reach the nucleus by escaping the ensuing barriers to exhibit a better drug activity and gene expression. OBJECTIVE:This review epigrammatically highlights the significance of targeted drug delivery and presents a comprehensive description of the principal barriers faced by the nucleus targeted drug delivery paradigm and ensuing complexities thereof. Eventually, the progress of nucleus targeting with nucleic acid aptamers and success achieved so far have also been reviewed. METHODS:Systematic literature search was conducted of research published to date in the field of nucleic acid aptamers. CONCLUSION:The review specifically points out the contribution of individual aptamers as the nucleustargeting agent rather than aptamers in conjugated form.

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http://hdl.handle.net/10453/147949