A Dyadic Growth Modeling Approach for Examining Associations Between Weight Gain and Lung Function Decline.

Cornelius, T; Schwartz, JE; Balte, P; Bhatt, SP; Cassano, PA; Currow, D; Jacobs, DR; Johnson, M; Kalhan, R; Kronmal, R; Loehr, L; O'Connor, GT; Smith, B; White, WB; Yende, S; Oelsner, EC

A Dyadic Growth Modeling Approach for Examining Associations Between Weight Gain and Lung Function Decline.

Cornelius, T Schwartz, JE Balte, P Bhatt, SP Cassano, PA Currow, D

Jacobs, DR Johnson, M Kalhan, R Kronmal, R Loehr, L O'Connor, GT Smith, B White, WB Yende, S Oelsner, EC

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Publisher:: Bloomberg School of Public Health
Publication Type:: Journal Article
Citation:: American Journal of Epidemiology, 2020, 189, (10), pp. 1173-1184
Issue Date:: 2020-10

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Field	Value	Language
dc.contributor.author	Cornelius, T
dc.contributor.author	Schwartz, JE
dc.contributor.author	Balte, P
dc.contributor.author	Bhatt, SP
dc.contributor.author	Cassano, PA
dc.contributor.author	Currow, D https://orcid.org/0000-0003-1988-1250
dc.contributor.author	Jacobs, DR
dc.contributor.author	Johnson, M
dc.contributor.author	Kalhan, R
dc.contributor.author	Kronmal, R
dc.contributor.author	Loehr, L
dc.contributor.author	O'Connor, GT
dc.contributor.author	Smith, B
dc.contributor.author	White, WB
dc.contributor.author	Yende, S
dc.contributor.author	Oelsner, EC
dc.date.accessioned	2021-04-15T05:33:50Z
dc.date.available	2020-04-10
dc.date.available	2021-04-15T05:33:50Z
dc.date.issued	2020-10
dc.identifier.citation	American Journal of Epidemiology, 2020, 189, (10), pp. 1173-1184
dc.identifier.issn	0002-9262
dc.identifier.issn	1476-6256
dc.identifier.uri	http://hdl.handle.net/10453/148127
dc.description.abstract	The relationship between body weight and lung function is complex. Using a dyadic multilevel linear modeling approach, treating body mass index (BMI; weight (kg)/height (m)2) and lung function as paired, within-person outcomes, we tested the hypothesis that persons with more rapid increase in BMI exhibit more rapid decline in lung function, as measured by forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and their ratio (FEV1:FVC). Models included random intercepts and slopes and adjusted for sociodemographic and smoking-related factors. A sample of 9,115 adults with paired measurements of BMI and lung function taken at ≥3 visits were selected from a pooled set of 5 US population-based cohort studies (1983-2018; mean age at baseline = 46 years; median follow-up, 19 years). At age 46 years, average annual rates of change in BMI, FEV1, FVC, and FEV1:FVC ratio were 0.22 kg/m2/year, -25.50 mL/year, -21.99 mL/year, and -0.24%/year, respectively. Persons with steeper BMI increases had faster declines in FEV1 (r = -0.16) and FVC (r = -0.26) and slower declines in FEV1:FVC ratio (r = 0.11) (all P values < 0.0001). Results were similar in subgroup analyses. Residual correlations were negative (P < 0.0001), suggesting additional interdependence between BMI and lung function. Results show that greater rates of weight gain are associated with greater rates of lung function loss.
dc.format	Print
dc.language	eng
dc.publisher	Bloomberg School of Public Health
dc.relation.ispartof	American Journal of Epidemiology
dc.relation.isbasedon	10.1093/aje/kwaa059
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	01 Mathematical Sciences, 11 Medical and Health Sciences
dc.subject.classification	Epidemiology
dc.subject.mesh	Adult
dc.subject.mesh	Aged
dc.subject.mesh	Body Mass Index
dc.subject.mesh	Cohort Studies
dc.subject.mesh	Humans
dc.subject.mesh	Linear Models
dc.subject.mesh	Lung
dc.subject.mesh	Middle Aged
dc.subject.mesh	Respiratory Function Tests
dc.subject.mesh	Weight Gain
dc.subject.mesh	Lung
dc.subject.mesh	Humans
dc.subject.mesh	Weight Gain
dc.subject.mesh	Respiratory Function Tests
dc.subject.mesh	Body Mass Index
dc.subject.mesh	Linear Models
dc.subject.mesh	Cohort Studies
dc.subject.mesh	Adult
dc.subject.mesh	Aged
dc.subject.mesh	Middle Aged
dc.subject.mesh	Adult
dc.subject.mesh	Aged
dc.subject.mesh	Body Mass Index
dc.subject.mesh	Cohort Studies
dc.subject.mesh	Humans
dc.subject.mesh	Linear Models
dc.subject.mesh	Lung
dc.subject.mesh	Middle Aged
dc.subject.mesh	Respiratory Function Tests
dc.subject.mesh	Weight Gain
dc.title	A Dyadic Growth Modeling Approach for Examining Associations Between Weight Gain and Lung Function Decline.
dc.type	Journal Article
utslib.citation.volume	189
utslib.location.activity	United States
utslib.for	01 Mathematical Sciences
utslib.for	11 Medical and Health Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/IMPACCT
utslib.copyright.status	closed_access	*
pubs.consider-herdc	true
dc.date.updated	2021-04-15T05:33:49Z
pubs.issue	10
pubs.publication-status	Published
pubs.volume	189
utslib.citation.issue	10

Abstract:

The relationship between body weight and lung function is complex. Using a dyadic multilevel linear modeling approach, treating body mass index (BMI; weight (kg)/height (m)2) and lung function as paired, within-person outcomes, we tested the hypothesis that persons with more rapid increase in BMI exhibit more rapid decline in lung function, as measured by forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and their ratio (FEV1:FVC). Models included random intercepts and slopes and adjusted for sociodemographic and smoking-related factors. A sample of 9,115 adults with paired measurements of BMI and lung function taken at ≥3 visits were selected from a pooled set of 5 US population-based cohort studies (1983-2018; mean age at baseline = 46 years; median follow-up, 19 years). At age 46 years, average annual rates of change in BMI, FEV1, FVC, and FEV1:FVC ratio were 0.22 kg/m2/year, -25.50 mL/year, -21.99 mL/year, and -0.24%/year, respectively. Persons with steeper BMI increases had faster declines in FEV1 (r = -0.16) and FVC (r = -0.26) and slower declines in FEV1:FVC ratio (r = 0.11) (all P values < 0.0001). Results were similar in subgroup analyses. Residual correlations were negative (P < 0.0001), suggesting additional interdependence between BMI and lung function. Results show that greater rates of weight gain are associated with greater rates of lung function loss.

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http://hdl.handle.net/10453/148127